Leptin and leptin receptor in anterior pituitary function

Pituitary

Volumn 4, Issue 1-2, 2001, Pages 33-47

  Lloyd, Ricardo V ^a,b   Jin, Long ^a,b   Tsumanuma, Itaru ^a,b   Vidal, Sergio ^c   Kovacs, Kalman ^d   Horvath, Eva ^d   Scheithauer, Bernd W ^a,b   Couce, Marta E ^d   Burguera, Bartolome ^e  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d Department of Pathology ^*  (United States)

^e UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Leptin; Leptin receptor; Pituitary

Indexed keywords

CYTOKINE; GROWTH HORMONE; HYPOPHYSIS HORMONE; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; STAT PROTEIN; THYROTROPIN;

ADENOHYPOPHYSIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HORMONE RELEASE; HUMAN; HUMAN TISSUE; HYPOPHYSIS CELL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PUBERTY; RAT; SECRETORY GRANULE; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE;

AGING; ANIMALS; CARRIER PROTEINS; GONADS; GROWTH HORMONE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LEPTIN; PITUITARY GLAND, ANTERIOR; PITUITARY-ADRENAL SYSTEM; RECEPTORS, CELL SURFACE; THYROID GLAND;

EID: 0035692819     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012982626401     Document Type: Article

References (163)

1. Neuroendocrine regulation and actions of leptin
2. Human leptin: From an adipocyte hormone to an endocrine mediator
3. Positional cloning of the mouse obese gene and its human homologue
4. Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice
5. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
6. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
7. Identification and expression cloning of a leptin receptor; OB-R
8. Abnormal splicing of the leptin receptor in diabetic mice
9. Effects of the obese gene product on body weight regulation in ob/ob mice
10. Functional domains of the granulocyte colony-stimulating factor receptor
11. Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
12. Identification and expression cloning of a leptin receptor, OB-R
13. Identification of targets of leptin action in rat hypothalamus
14. Localization of leptin receptor in the human brain
15. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
16. Divergent signaling capacities of the long and short isoforms of the leptin receptor
17. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
18. Functional STAT1 and 3 signaling by the leptin receptor (OB-R): Reduced expression of the rat fatty leptin receptor in transfected cells
19. Cytokine signal transduction
20. Reflections on STAT3, STAT5, and STAT6 as fat STATs
21. Leptin: Physiology and pathophysiology
22. Clinical review 90: Leptin and clinical medicine-a new piece in the puzzle of obesity
23. Regulation of circulating leptin in humans
24. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
25. Role of leptin in hypothalamic-pituitary function
26. Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat
27. Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissues and is differentially expressed in hypothalamic regions of well-fed and feed-restricted ewes
28. The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey
29. Leptin and leptin receptor expression in normal and neoplastic human pituitary evidence of a regulatory role for leptin on pituitary cell proliferation
30. Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion
31. Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma
32. Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
33. Synthesis of leptin in human placenta
34. The stomach is a source of leptin
35. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
36. Leptin expression in human mammary epithelial cells and breast milk
37. Leptin and leptin receptor expression in rat and mouse pituitary cells
38. Leptin gene expression in the brain and pituitary gland
39. Subcellular localization of leptin in non-tumorous and adenomatous human pituitaries: An immuno-ultrastructural study
40. Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion
41. The chromogranins A and B: The first 25 years and future perspectives
42. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes
43. Physiological significance of somatostatin in growth hormone regulation
44. The physiology and chemistry of growth hormone
45. Regulation of growth hormone secretion in acromegaly
46. Serum growth hormone and prolactin during and after the development of the obese-hyperglycemic syndrome in mice
47. The hypothalamic-pituitary axis in genetically obese (ob/ob) mice: Response to luteinizing hormone-releasing hormone
48. Regulation of in vivo growth hormone secretion by leptin
49. Upregulation of leptin receptor gene expression in the anterior pituitary of human growth hormone-releasing hormone transgenic mice
50. Effects of food deprivation on the GH axis: Immunocytochemical and molecular analysis
51. Role of leptin in the neuroendocrine response to fasting
52. Transient increase in obese gene expression after food intake or insulin administration
53. Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels
54. The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland
55. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat
56. Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone
57. Physiologically significant effect of neuropeptide Y to suppress growth hormone release by stimulating somatostatin discharge
58. The expression of leptin and its receptors in pre-ovulatory human follicles
59. Interaction between leptin and neuropeptide Y on in vivo growth hormone secretion
60. Elevated leptin concentrations in growth hormone-deficient hypopituitary adults
61. Serum leptin is increased in growth hormone-deficient adults: Relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year
62. Short-term changes in serum leptin levels provide a strong metabolic marker for the growth response to growth hormone treatment in children
63. Effect of growth hormone (GH) on serum concentrations of leptin: Study in patients with acromegaly and GH deficiency
64. Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency
65. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
66. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function
67. Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion
68. Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue: Increased responsiveness to glucocorticoids
69. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects
70. Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA
71. Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants
72. Identification of targets of leptin action in rat hypothalamus
73. Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain
74. Expression of Ob receptor in normal human adrenals: Differential regulation of adrenocortical and adrenomedullary function by leptin
75. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
76. Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome
77. Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone
78. Sympathetic and cardiorenal actions of leptin
79. Chronic leptin infusion increases arterial pressure
80. Human leptin may function as a diuretic/natriuretic hormone
81. Hyperreninemic hypoaldosteronism in the critically ill: A new entity
82. Receptor-mediated regional sympathetic nerve activation by leptin
83. Leptin receptors in the adrenal medulla of the rat
84. The praganglionic chemoreceptor system
85. Dissociation of sympathetic nervous system and adrenal medullary responses
86. Glucocorticoids as counterregulatory hormones of leptin: Toward an understanding of leptin resistance
87. A regulatory loop between the hypothalamo-pituitary-adrenal (HPA) axis and circulating leptin: A physiological role of ACTH
88. Acute effects of recombinant murine leptin on rat pituitary-adrenocortical function
89. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland
90. The interaction between leptin and the hypothalamic-pituitary-thyroid axis
91. Copulsatile release of thyrotropin and prolactin in normal and hypothyroid subjects
92. Pulsatile secretion of thyrotropin in children
93. Pathophysiology of pulsatile and copulsatile release of thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, and alpha-subunit
94. Hypothalamic regulation of pulsatile thyrotopin secretion
95. Is leptin a stress related peptide?
96. Leptin levels are elevated despite low thyroid hormone levels in the "euthyroid sick" syndrome
97. Relationship between thyrotropin and thyroxine changes during recovery from severe hypothyroxinemia of critical illness
98. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
99. Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus
100. The arcuate nucleus is the major source for neuropeptide Y-innervation of thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
101. Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus
102. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
103. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin
104. Leptin regulates prothyrotropin-releasing hormone biosynthesis: Evidence for direct and indirect pathways
105. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
106. Endocrine function of neuropeptide Y knockout mice
107. Anatomical interactions of proopiomelanocortin (POMC)-related peptides, neuropeptide Y (NPY) and dopamine beta-hydroxylase (D beta H) fibers and thyrotropin-releasing hormone (TRH) neurons in the paraventricular hypothalamus
108. Influence of thyroid status on serum immunoreactive leptin levels
109. Thyroid dysfunction is not associated with alterations in serum leptin levels
110. Lack of effects of circulating thyroid hormone levels on serum leptin concentrations
111. Short-term hyperthyroidism has no effect on leptin levels in man
112. Thyroid hormones influence serum leptin concentrations in the rat
113. Leptin and the thyroid-A puzzle with missing pieces
114. Regulation of expression of leptin mRNA and secretion of leptin by thyroid hormone in 3T3-L1 adipocytes
115. Expression of leptin and beta 3-adrenergic receptors in rat adipose tissue in altered thyroid states
116. Early onset of reproductive function in normal female mice treated with leptin
117. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty
118. Serum leptin levels in normal children: Relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal state
119. Leptin is a metabolic signal to the reproductive system
120. Metabolic control of sexual function and growth: Role of neuropeptide Y and leptin
121. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
122. Sexual dimorphism in plasma leptin concentration
123. Effects of gender, body composition, and menopause on plasma concentrations of leptin
124. Gender differences in serum leptin levels in humans
125. The metabolic significance of leptin in humans: Gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure
126. Testosterone replacement increases fat-free mass and muscle size in hypogonadal men
127. Testosterone treatment in adolescents with delayed puberty: Changes in body composition, protein, fat, and glucose metabolism
128. Inverse correlation between serum testosterone and leptin in men
129. Leptin concentrations, sex hormones, and cortisol in non-diabetic men
130. The decrease of serum leptin levels in oestrogen-treated male mice
131. Estrogen increases in vivo leptin production in rats and human subjects
132. Serum leptin levels in women with anorexia nervosa
133. Hypothalamic control of FSH and LH by FSH-RF, LHRH, cytokines, leptin and nitric oxide
134. Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland
135. Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep
136. Localization of leptin receptor-like immunoreactivity in the corticotropes, somatotropes and gonadotropes in the ovine anterior pituitary
137. Expression of a leptin receptor in immortalized gonadotropin-releasing hormone-secreting neurons
138. Increased body weight associated with prolactin secreting pituitary adenomas: Weight loss with normalization of prolactin levels
139. Functional delineation of hyperprolactinemic-amenorrhea
140. Psychosomatic factors in patients with hyperprolactinemia and/or galactorrhea
141. Presence of leptin in colostrum and/or breast milk from lactating mothers: A potential role in the regulation of neonatal food intake
142. Folliculostellate cells of the pituitary
143. Origin, possible function and fate of "follicular cells" in the anterior lobe of the human pituitary
144. Evidence for functional communication between folliculo-stellate cells and hormone-secreting cells in perifused anterior pituitary cell aggregates
145. Production of bioactive and immunoreactive interleukin-6 (IL-6) and expression of IL-6 messenger ribonucleic acid by human pituitary adenomas
146. Analysis of S-100 protein positive folliculo-stellate cells in rat pituitary tissues
147. Immunocytochemical evidence that S-100-positive cells of the mouse anterior pituitary contain interleukin-6 immunoreactivity
148. Cytokines: Autocrine and paracrine roles in the anterior pituitary
149. Production of interleukin-6 by anterior pituitary cells in vitro
150. Leptin and OB-R: Body weight regulation by a cytokine receptor
151. Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system
152. Characterization of interleukin-2 (IL-2) receptor expression and action of IL-2 and IL-6 on normal anterior pituitary cell growth
153. Involvement of interleukin-1 and interleukin-1 receptor antagonist in rat pituitary cell growth regulation
154. Analysis of homogeneous populations of anterior pituitary folliculo-stellate cells by laser capture microdissection and RT-PCR
155. The long form of leptin receptor (OB-Rb) is widely expressed in the human brain
156. Pituitary corticotroph socs-3: Novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion
157. Autoregulation of pituitary corticotroph socs-3 expression: Characterization of the murine socs-3 promoter
158. Inhibitory roles for shp-1 and socs-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor
159. A human pituitary adenoma cell line proliferates and maintain some differentiated functions following expression of SV40 large t-antigen
160. Leptin signal transduction in the HP75 human pituitary cell line
161. Socs-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses stat5 phosphorylation and lymphocyte proliferation
162. Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway
163. Leukemia inhibitory factor regulates proopiomelanocortin transcription