Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome

Hormone and Metabolic Research

Volumn 28, Issue 12, 1996, Pages 711-713

  Leal Cerro, A ^a   Considine, R V ^d   Peino, R ^b   Venegas, E ^a   Astorga, R ^a   Casanueva, F F ^b   Dieguez, C ^c,e  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e NONE   (Spain)

Author keywords

adipose tissue; food intake; glucocorticoids; obesity

Indexed keywords

LEPTIN;

ADULT; ARTICLE; BLOOD ANALYSIS; BODY MASS; CASE REPORT; CONTROLLED STUDY; CUSHING SYNDROME; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0030478339     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-979884     Document Type: Article

References (17)

1. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549 (1995).
2. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer JL, Rosato EL, Colberg J, Caro JF: Evidence against either a premature stop coclon or the absence of obese gene mRNA in human obesity. J Clin Invest 95: 2986-2988 (1995).
3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma proteins encoded by the obese gene Science 269: 543-546 (1995).
4. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543 (1995).
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homolgue. Nature 372, 425-432 (1994) (Erratum Nature 1995, 374: 479).
6. Hamilton BS, Paglia D, Kwan AYM, Deitel M: Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Medicine 1: 953-956 (1995).
7. Lönnqvist F, Arner P, Nordfors L, Schalling M: Overexpression of the olwse (ob) gene in adipose tissue of human obese subjects. Nature Medicine 1: 950-933 (1995).
8. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Mrco CC, McKee JL, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal weight and obese humans. N Engl J Med 334: 292-295 (1996).
9. Jeanrenaud FR, Jeanrenaud B: Obesity, leptin and the brain. N Engl J Med 334: 324-325 (1996).
10. Meier CA: Leptin secretion and action: an update. Eur J Endocrinol 134: 543-544 (1996).
11. Considine RV, Nyce MR, Kolaczynsky JW, Zhang P, Sinha M, Ohannessian JP, Moore J, Fox J, Caro JF: Insulin inhibits the dexamethasone stimulated increase in Ob gene expression in human adipocytes. 56th Annual Meeting of the American Diabetes Association. Abstract San Francisco (1996).
12. De Vos P, Saladin R, Auwer J, Staels B: Induction of Ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270: 15958-15961 (1995).
13. Murakami T, Lida M, Shima K: Dexamethasone regulates Ob gene expression in isolated rat adipocytes. Biochem Biophys Res Comm 214: 1260- 1267 (1995).
14. Todd G: Hormonal and Cytokine regulation of leptin production in adipocytes. Abstract 822. Annual Meeting of the American Diabetes Association. San Francisco, USA (1996).
15. Davenport L, Knehans A, Sundestrom A, Tomas T: Corticosterone's dual metabolic actions. Life Sci 45: 1389-1396 (19989).
16. Gong DW, Bi S, Pratley RE, Weintraub BD: Genomic structure and promoter analysis of the human obese gene. J Biol Chem 271: 3971-3974 (1996).
17. Sinha MK, Ohannesian JP, Heiman MI, Kriauaciunas A, Stephens TW, Magosin S, Marco C, Caro JF: Nocturnal rise of leptin in lean, obese and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 97: 1344-1347 (1996).