Testosterone treatment in adolescents with delayed puberty: Changes in body composition, protein, fat, and glucose metabolism

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 10, 1997, Pages 3213-3220

  Arslanian, Silva ^a   Suprasongsin, Chittiwat ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

ADOLESCENT; ARTICLE; BODY DISTRIBUTION; BODY FAT; BODY MASS; CLINICAL ARTICLE; DELAYED PUBERTY; GLUCOSE METABOLISM; HORMONE SUBSTITUTION; HUMAN; INSULIN RESISTANCE; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; TREATMENT OUTCOME;

ADOLESCENT; BODY COMPOSITION; FATS; GLUCOSE; HUMANS; HYPERINSULINISM; LONGITUDINAL STUDIES; MALE; OXIDATION-REDUCTION; PROTEINS; PUBERTY, DELAYED; TESTOSTERONE;

EID: 0030953347     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.10.3213     Document Type: Article

References (59)

1. Amiel SA, Sherwin RS, Simonson DC, Lauritano AA, Tamborlane WV. 1986 Impaired insulin action in puberty: a contributing factor to poor glycemic control in adolescents with diabetes. N Engl J Med. 315:215-219.
2. Bloch CA, demons P, Sperling MA. 1987 Puberty decreases insulin sensitivity. J Pediatr. 110:481-487.
3. Arslanian SA, Kalhan SC. 1994 Correlations between fatty acid and glucose metabolism: potential explanation of insulin resistance of puberty Diabetes 43:908-914.
4. Tanner JM. 1981 Growth and maturation during adolescence. Nutr Rev. 39:43-55.
5. Arslanian SA, Kalhan SC. 1996 Protein turnover during puberty in normal children. Am J Physiol. 270:E79-E84.
6. Albertsson-Wikland K, Rosberg S, Karlberg J, Groth T. 1994 Analysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: relation to puberty. J Clin Endocrinol Metab. 78:1195-1201.
7. Keenan BS, Richards GE, Ponder SW, Dallas JS, Nagamani M, Smith ER. 1993 Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-1 in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab. 76:996-1001.
8. Woodward CJH. 1993 A re-evaluation of the anabolic effect of testosterone in rats: interactions with gonadectomy, adrenalectomy and hypophysectomy. Acta Endocrinol (Copenh). 128:473-477.
9. Tenover JS. 1992 Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab. 75:1092-1098.
10. Forbes GB, Porta CR, Herr BE, Briggs RC. 1992 Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped. JAMA. 267:397-399.
11. Welle S, Jozefowicz R, Forbes G, Griggs RC. 1992 Effect of testosterone on metabolic rate and body composition in normal men and men with muscular dystrophy. J Clin Endocrinol Metab. 74:332-335.
12. Brodsky IG, Balagopal P, Sreekumaran NK. 1996 Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men. J Clin Endocrinol Metab. 81:3469-3475.
13. Bhasin S, Storer TW, Berman N, et al. 1997 Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. J Clin Endocrinol Metab. 82:407-413.
14. Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A. 1996 Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab. 81:4358-4365.
15. Mauras N, Haymond MW, Darmaun DM, Vieira NE, Adams SA, Yergey AL. 1994 Calcium and protein kinetics in prepubertal boys. Positive effects of testosterone. J Clin Invest. 93:1014-1019.
16. Kulin HE. 1996 Delayed puberty. J Clin Endocrinol Metab. 81:3460-3464.
17. Richman RA, Kirsh LR. 1988 Testosterone treatment in adolescent boys with constitutional delay in growth and development. N Engl J Med. 319:1563-1567.
18. Schutz Y. 1995 The basis of direct and indirect calorimetry and their potentials. Diabetes Metabol Rev. 11:383-408.
19. Suprasongsin C, Kalhan S, Arslanian S. 1995 Determination of body composition in children and adolescents: validation of bioelectrical impedance with isotope dilution technique. J Ped Endocrinol Metab. 8:103-109.
20. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ. 1965 Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab. 25:1375-1384.
21. Austin A, Warty V, Janosky J, Arslanian S. 1993 The relationship of physical fitness to lipid and lipoprotein (a) levels in adolescents with IDDM. Diabetes Care. 16:421-424.
22. Ma Z, Gingerich RL, Santiago JU, Klein S, Smith CH, Landt M. 1996 Kadioimmunoassay of leptin in human plasma. Clin Chem. 42:942-946.
23. DiGiorgio J. 1974 Nonprotein nitrogenous constituents. In: Henry KJ, Connon DC, Winkelman JW (eds) Clinical Chemistry: Principles and Techniques. Hagerstown, MD: Harper and Row; 503-563.
24. VanGoudoever JB, Wattimena JDL, Carnielli VP, Sulkers EJ, Degenhart HJ, Sauer PJJ. 1994 Effect of dexamethasone on protein metabolism in infants with bronchopulmonary dysplasia. J Pediatr. 124:112-118.
25. 2H stable isotopic tracers. Analytical Biochem. 205:172-178.
26. Schwenk WF, Beaufrere B, Haymond HW. 1985 Use of reciprocal pool specific activities to model leucine metabolism in humans. Am J Physiol. 249:E645-E650.
27. Waterlow JC. 1984 Protein turnover with special reference to man. J Exp Physiol. 69:409-438.
28. Tserng K. Kalhan SC. 1983 Calculation of substrate turnover rate in stable isotope tracer studies. Am J Physiol. 245:E308-E311.
29. Amiel SA, Caprio S, Sherwin RS, Plewe G, Haymond MW, Tamborlane WV. 1991 Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism. J Clin Endocrinol Metab. 72:277-282.
30. Frayn KN. 1983 Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol. 55:628-634.
31. DeFronzo R, Tobin J, Andres R. 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214-E223.
32. Draper NR, Smith H. 1996 Applied regression analysis. New York: John Wiley & Sons.
33. Griggs RC, Kingston W, Jozefowicz RF, Herr BE, Forbes G, Holliday D. 1989 Effect of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol. 66:498-503.
34. Young NR, Baker HW, Liu G, Seeman E. 1993 Body composition and muscle strength in healthy men receiving testosterone enanthate tor contraception. J Clin Endocrinol Metab. 77:1028-1032.
35. Wang C, Eyre DR, Kleinberg CD. 1996 Sublingual testosterone replacement improves muscle moss and strength, decreases bone resorption and increases bone formation markers in hypogonadal men. J Clin Endocrinol Metab. 81:3654-3662.
36. Griggs RC, Pandya S, Florence JM. 1989 Randomised controlled trial of testosterone in myotonic dystrophy. Neurology. 34:219-222.
37. Urban RJ, Bodenburg YH, Gilkison C. 1995 Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol. 269:E820-E826.
38. Eakman GD, Dallas JS, Ponder SW, Keenan BS. 1996 The effects of testosterone and dihydrotestosterone on hypothalamic regulation of growth hormone secretion. J Clin Endocrinol Metab. 81:1217-1223.
39. Weissberger AJ, Ho KKY. 1993 Activation of the somatotropin axis by testosterone in adult males: evidence for the role of aromatization. J Clin Endocrinol Metab. 76:1407-1412.
40. Fryburg DA, Barrett EJ. 1995 Insulin, growth hormone, and IGF-I regulation of protein metabolism. Diabetes Rev. 3:43-112.
41. Xu X, DePergola G, Bjorntorp P. 1991 Testosterone increases lipolysis and the number of β-adrenoreceptors in male rat adipocytes. Endocrinology. 128:379-382.
42. Xu X, DePergola G, Eriksson PS, Fu L, Carlsson B, Yang S, Eden S, Bjorntorp P. 1993 Post-receptor events involved in the up-regulation of β-adrenergic receptor mediated lipolysis by testosterone in rat white adipocytes. Endocrinology. 132:1651-1657.
43. Rebuffé-Scrive M, Marin P, Bjorntorp P. 1991 Effect of testosterone on abdominal adipose tissue in men. Int J Obes 2:791-795.
44. DePergola G, Xu X, Yang S, Giorgino R, Bjorntorp P. 1990 Up regulation of androgen receptor binding in male rat fat pad adipose precursor cells exposed to testosterone: study in the whole cell assay system. J Steroid Biochem Mol Biol. 37:553-558.
45. Bjorntorp P, Ottosson M, Rebuffé-Scrive M, Xu X. 1990 Regional obesity and steroid hormone interaction in human adipose tissue. In: Bray G, Ricquier D, Spiegelman B (eds) Obesity: Towards a Molecular Approach. New York: Alan R Liss; 147-157.
46. Marin P, Holmang S, Jonsson L, et al. 1992 The effects of testosterone treatment on body composition and metabolism in middle aged obese men. Int J Obes. 16:941-997.
47. Marin P, Oden B, Bjorntorp P, 1995 Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. J Clin Endocrinol Metab. 80:234-243.
48. Davidson MB. 1987 Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev. 8:115-131.
49. Yang S, Xu X, Bjorntorp P. Eden S. 1995 Additive effects of growth hormone and testosterone on lipolysis in adipocytes of hypophysectomized rats. J Endocrinol. 147:147-152.
50. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. 1996 Leptin: the tale of an obesity gene. Diabetes. 45:1455-1462.
51. Bagatell CJ, Bremner WJ. 1995 Androgens and progestogen effects on plasma lipids. Prog Cardiovasc Dis. 38:255-271.
52. Kirkland RT, Keenan BS, Probstfield JL, Patch W, Lin TL, Clayton GW, Insull W. 1987 Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence. Correlation with plasma testosterone levels. JAMA. 257:502-507.
53. Bagatell CJ, Heiman JR, Matsumato AM, Rivier JE, Bremner WJ. 1994 Metabolic and behavioral effects of high-dose exogenous testosterone in healthy men. J Clin Endocrinol Metab. 79:561-567.
54. Cohen JC, Hickman R. 1987 Insulin resistance and diminished glucose tolerance in power litters ingesting anabolic steroids. J Clin Endocrinol Metab. 64:960-971.
55. Simon D, Charles MA, Nahoul K, Orssaud G, Kremski J, Hully V, Joubert E, Papoz L, Eschwege E. 1997 Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the Telecom Study. J Clin Endocrinol Metab. 82:682-685.
56. Holmang A, Bjorntorp P. 1992 The effects of testosterone on insulin sensitivity in male rats. Acta Physiol Scand. 146:505-510.
57. Friedl KE, Jones RE, Hannan, Jr, CJ, Plymate SR. 1989 The administration of pharmacological closes of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance. J Clin Endocrinol Metab. 68:971-975.
58. Marin P, Krotkiewski M, Bjorntorp P. 1992 Androgen treatment of middle-aged obese men: effects on metabolism, muscle and adipose tissue. Eur J Med. 1:329-336.
59. Polansky KS, Gumbiner B, Ostrega D, Griver K, Tager H, Henry RR. 1994 Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in IDDM. Diabetes. 43:871-877.