Effect of growth hormone (GH) on serum concentrations of leptin: Study in patients with acromegaly and GH deficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 10, 1998, Pages 3476-3479

  Miyakawa, Megumi ^a   Tsushima, Toshio ^a   Murakami, Hitomi ^a   Isozaki, Osamu ^a   Demura, Hiroshi ^a   Tanaka, Toshiaki ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; LEPTIN; SOMATOMEDIN C;

ACROMEGALY; ADULT; ARTICLE; BODY FAT; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; MALE; OBESITY; PRIORITY JOURNAL;

ACROMEGALY; ADIPOSE TISSUE; ADULT; BODY COMPOSITION; BODY MASS INDEX; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; PROTEINS; REFERENCE VALUES; SEX CHARACTERISTICS;

EID: 0031796402     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.10.3476     Document Type: Article

References (35)

1. Zhang Y, Proenca R, Maffei M, Barone N, Leopold L, Friedman JM. 1994 Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
2. Pelleymouter MA, Cullen MJ, Baker MB, et al. 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:540-543.
3. Halaas JL, Gajiwala KS, Maffei M, et al. 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
4. Lonqvist F, Arner P, Nordfors L. Schalling M. 1995 Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med. 1:953-956.
5. Considine RV, Sinha MK, Heiman ML, et al. 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:292-295.
6. Maffei M, Halaas JM, Rarussin E, et al. 1995 Measurements of plasma leptin and ob mRNA in obese and weight reduced subjects. Nat Med. 1:1155-1161.
7. Dagogo-Jack S, Fanelli C, Paramore D, et al. 1996 Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes. 45:695-698.
8. Kolaczynski JW, Nyce MR, Considine RV, et al. 1996 Acute and chronic effect of insulin on leptin production in humans. Studies in vitro and in vivo. Diabetes. 45:699-701.
9. Segal KR, Landt M, Klein S. 1996 Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes. 45:988-991.
10. Saladin R, De Vos P, Guerre-Millo M, et al. 1995 Transient increase in obese expression after food intake or insulin administration. Nature. 377:527-529.
11. Larsson H, Ahren BO. 1996 Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. J Clin Endocrinol Metab. 81:4428-4432.
12. Slicker LJ, Sloop KW, Surface PL, et al. 1996 Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem. 27:15301-5304.
13. Shimizu H, Shimomura Y, Nakanishi Y, et al. 1997 Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol. 154:285-292.
14. Mantzoros CS, Qu D, Federich RC, et al. 1996 Activation of β3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes. 45:909-914.
15. Wabittsch M, Blum WF, Muche R, et al. 1997 Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest. 100:808-813.
16. Nystrom F, Ekman B, Osterlund M, Lindstom T, Ohman KP, Arnqvist HJ. 1997 Serum leptin concentrations in a normal population and in GH deficiency: negative correlation with testosterone in men and effects of GH treatment. Clin Endocrinol (Oxf). 47:191-198.
17. Veldhuis JD, Iranmmanesh A, Ho KKY, et al. 1991 Dual effects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab. 72:51-59.
18. Davidson MB. 1987 Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev. 8:115-131.
19. Salomon F, Cuneo RC, Hesp R, Sonksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 321:1797-1803.
20. De Boer H, Blok GJ, Voerman HJ, De Vries PMJM, Van der Veen EA. 1992 Body composition in adult growth hormone-deficient men, assessed by anthrometry and bioimpedance analysis. J Clin Endocrinol Metab. 75:833-837.
21. Binnerts A, Deurenberg P, Swart GR, Wlson JHP, Lamberts SWJ. 1992 Body composition in growth hormone-deficient adults. Am J Clin Nutr. 55:918-923.
22. Rosen T, Boseaeus I, Tolli J, Lindstedt G, Sonksen PH. 1993 Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin Endocrinol (Oxf). 38:63-71.
23. Bengtsson BA, Brummer R-J M, Eden S, Bosaeus I. 1989 Body composition in acromegaly. Clin Endocrinol (Oxf). 30:121-130.
24. Carro E, Senaris R, Considine RV, Casanueva FF, Dieguez C. 1997 Regulation of in vivo growth hormone secretion by leptin. Endocrinology. 138:2203-2206.
25. Boni-Schnetzler M, Gosteli-Peter MA, Moritz W, et al. 1996 Reduced ob mRNA in hypophysectomised rats is not restored by growth hormone (GH), but further suppressed by exogenously administered insulin-like growth factor (IGF) I. Biochem Biophys Res Commun. 225:296-301.
26. Berneis K, Vosmeer S, Keller U. 1996 Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. Eur J Endocrinol. 135:663-665.
27. Florkowski CNM, Collier GR, Zimmet PZ, et al. 1997 Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol (Oxf) 45:769-773.
28. Fisker S, Vahl N, Hansen TB, et al. 1997 Serum leptin is increased in growth hormone-deficient adults: relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year. Metabolism. 46:812-817.
29. Likaski HC, Bolochuk WW, Hall CB, Siders WA. 1988 Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol. 60:1327-1332.
30. Kennedy A, Gettys TW, Watson P, et al. 1997 The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab. 82:1293-1300.
31. Saad MF, Damani S, Gingerich RL, et al. 1997 Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab. 82:579-584.
32. Nagy TR, Gower BA, Trowbridge CA, Dezenberg C, Shewchuk RA, Goran MI. 1997 Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children. J Clin Endocrinol Metab 82:2148-2152.
33. Utriainen T, Malmstrom R, Makimattila S, Yki-Jarvinen H. 1996 Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4h in normal subjects. Diabetes. 45:1364-1366.
34. Desautels M, Bhaumick B, Ram JI. 1996 Comparison of trophic effects of norepinephrine, insulin, and IGF-I in mouse brown adipocytes. Am J Physiol. 270:R1287-R1295.
35. Paolisso G, Ammendola S, Buono AD, et al. 1997 Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function. J Clin Endocrinol Metab. 82:2204-2209.