메뉴 건너뛰기




Volumn 7, Issue 4, 1996, Pages 303-309

Leptin and OB-R: Body weight regulation by a cytokine receptor

Author keywords

Hypothalamus; Leptin (OB); Leptin receptor (OB R); Obesity; Signal transduction

Indexed keywords

CARRIER PROTEIN; COMPLEMENTARY DNA; CYTOKINE RECEPTOR; LEPTIN; LEPTIN RECEPTOR; OB PROTEIN; PROTEIN; PROTEIN TYROSINE KINASE;

EID: 0030434655     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(96)00040-8     Document Type: Short Survey
Times cited : (91)

References (61)
  • 1
    • 0026518215 scopus 로고
    • Tackling a weighty problem
    • J.M. Friedman R.L. Leibel Tackling a weighty problem Cell 69 1992 217 220
    • (1992) Cell , vol.69 , pp. 217-220
    • Friedman, J.M.1    Leibel, R.L.2
  • 2
  • 3
    • 0014004384 scopus 로고
    • Diabetes, a new mutuation in the mouse
    • K.P. Hummel M.M. Dickie D.L. Coleman Diabetes, a new mutuation in the mouse Science 153 1966 1127 1128
    • (1966) Science , vol.153 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 4
    • 0018139377 scopus 로고
    • Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice
    • D.L. Coleman Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice Diabetologia 14 1978 141 148
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 5
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese and diabetes and normal mice
    • D.L. Coleman Effects of parabiosis of obese and diabetes and normal mice Diabetologia 9 1973 294 298
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 6
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Y Zhang R Proenca M Maffei M Barone L Leopold J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 431
    • (1994) Nature , vol.372 , pp. 425-431
    • Zhang, Y1    Proenca, R2    Maffei, M3    Barone, M4    Leopold, L5    Friedman, J.M.6
  • 8
    • 85114550685 scopus 로고    scopus 로고
    • Madej T, Boguski MS, Bryant SH. Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett 373 , 13–18.
  • 9
    • 0029983180 scopus 로고    scopus 로고
    • Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow a gout) obesity
    • T.M. Mizuno H Bergen T Funabashi S.P. Kleopoulos Y.G. Zhong W.A. Bauman C.V. Mobbs Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow a gout) obesity Proc Natl Acad Sci USA 93 1996 3434 3438
    • (1996) , pp. 3434-3438
    • Mizuno, T.M.1    Bergen, H2    Funabashi, T3    Kleopoulos, S.P.4    Zhong, Y.G.5    Bauman, W.A.6    Mobbs, C.V.7
  • 10
    • 0029157428 scopus 로고    scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • R Saladin P De Vos M Guerre-Millo A Leturque J Girard B Staels J Auwerx Transient increase in obese gene expression after food intake or insulin administration Nature 377 1996 527 529
    • (1996) Nature , vol.377 , pp. 527-529
    • Saladin, R1    De Vos, P2    Guerre-Millo, M3    Leturque, A4    Girard, J5    Staels, B6    Auwerx, J7
  • 15
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action
    • R Frederich A Hamann S Anderson B Lollman B Lowell J Fleir Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action Nature Med 1 1995 1311 1314
    • (1995) Nature Med , vol.1 , pp. 1311-1314
    • Frederich, R1    Hamann, A2    Anderson, S3    Lollman, B4    Lowell, B5    Fleir, J6
  • 16
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
    • A.L. Campfield F.J. Smith Y Guisez R Devos P Burn Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546 549
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, A.L.1    Smith, F.J.2    Guisez, Y3    Devos, R4    Burn, P5
  • 21
    • 0029083859 scopus 로고
    • Increased obese mRNA expression in omental fat cells from massively obese humans
    • B.S. Hamilton D Paglia A.T.M. Kwan M Deitel Increased obese mRNA expression in omental fat cells from massively obese humans Nature Med 1 1995 953 956
    • (1995) Nature Med , vol.1 , pp. 953-956
    • Hamilton, B.S.1    Paglia, D2    Kwan, A.T.M.3    Deitel, M4
  • 22
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • F Lonnqvist P Arner L Nordfors M Shalling Overexpression of the obese (ob) gene in adipose tissue of human obese subjects Nature Med 1 1995 950 953
    • (1995) Nature Med , vol.1 , pp. 950-953
    • Lonnqvist, F1    Arner, P2    Nordfors, L3    Shalling, M4
  • 24
    • 0029938057 scopus 로고    scopus 로고
    • Extreme obesity may be linked to markers flanking the human ob gene
    • D.R. Reed Y Ding W Xu C Cather E.D. Green R.A. Price Extreme obesity may be linked to markers flanking the human ob gene Diabetes 45 1996 691 694
    • (1996) Diabetes , vol.45 , pp. 691-694
    • Reed, D.R.1    Ding, Y2    Xu, W3    Cather, C4    Green, E.D.5    Price, R.A.6
  • 28
    • 0028085078 scopus 로고
    • The insulin signaling system
    • M.K. White C.R. Kahn The insulin signaling system J Biol Chem 269 1994 1 4
    • (1994) J Biol Chem , vol.269 , pp. 1-4
    • White, M.K.1    Kahn, C.R.2
  • 31
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gpl30
    • T Taga M Hibi Y Hirata K Yamasaki K Yasukawa T Matsuda T Hirano T Kishimoto Interleukin-6 triggers the association of its receptor with a possible signal transducer, gpl30 Cell 58 1989 573 581
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T1    Hibi, M2    Hirata, Y3    Yamasaki, K4    Yasukawa, K5    Matsuda, T6    Hirano, T7    Kishimoto, T8
  • 33
    • 0025204831 scopus 로고
    • Three different mRNAs encoding human granulocyte colonystimulating factor receptor
    • R Fukunaga Y Seto S Mizushima S Nagata Three different mRNAs encoding human granulocyte colonystimulating factor receptor Proc Natl Acad Sci 87 1990 8702 8706
    • (1990) , pp. 8702-8706
    • Fukunaga, R1    Seto, Y2    Mizushima, S3    Nagata, S4
  • 34
    • 0025604307 scopus 로고
    • Expression cloning of a granulocyte colony stimulating factor receptor: a structural mosaic of hematopoietan receptor, immunoglobin and fibronectin domains
    • A Larsen T Davis B.M. Curtis S Gimpel J.E. Sims D Cosman L Park E Sorenson C.J. March C.A. Smith Expression cloning of a granulocyte colony stimulating factor receptor: a structural mosaic of hematopoietan receptor, immunoglobin and fibronectin domains J Exp Med 172 1990 1559 1570
    • (1990) J Exp Med , vol.172 , pp. 1559-1570
    • Larsen, A1    Davis, T2    Curtis, B.M.3    Gimpel, S4    Sims, J.E.5    Cosman, D6    Park, L7    Sorenson, E8    March, C.J.9    Smith, C.A.10
  • 35
    • 0025861158 scopus 로고
    • Functional domains of the granulocyte colonystimulating factor receptor
    • R Fukunaga E Ishizaka-Ikeda C.-X. Pan Y Seto S Nagata Functional domains of the granulocyte colonystimulating factor receptor EMBO 10 1991 2855 2865
    • (1991) EMBO , vol.10 , pp. 2855-2865
    • Fukunaga, R1    Ishizaka-Ikeda, E2    Pan, C.-X.3    Seto, Y4    Nagata, S5
  • 38
    • 0025942918 scopus 로고
    • The integrity of the conserved “ws motif” common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction
    • T Miyazaki M Marayama G Yamada M Hatakeyama T Taniguchi The integrity of the conserved “ws motif” common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction EMBO 10 1991 3191 3197
    • (1991) EMBO , vol.10 , pp. 3191-3197
    • Miyazaki, T1    Marayama, M2    Yamada, G3    Hatakeyama, M4    Taniguchi, T5
  • 39
    • 0026338754 scopus 로고
    • Critical cytoplasmic region of the interleukin-6 signal transducer gp130 is conserved in the cytokine receptor family
    • M Murakami M Narazaki M Hibi H Yawata K Yasukawa M Hamaguchi T Taga T Kishimoto Critical cytoplasmic region of the interleukin-6 signal transducer gp130 is conserved in the cytokine receptor family Proc Natl Acad Sci 88 1991 11349 11353
    • (1991) , pp. 11349-11353
    • Murakami, M1    Narazaki, M2    Hibi, M3    Yawata, H4    Yasukawa, K5    Hamaguchi, M6    Taga, T7    Kishimoto, T8
  • 43
    • 85114542772 scopus 로고    scopus 로고
    • Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets to leptin action in rate hypothalamus. J Clin Invest , in press.
  • 44
    • 0030015417 scopus 로고    scopus 로고
    • Defective STAT signaling by the leptin receptor in diabetic mice
    • N Ghilardi S Ziegler A Wiestner R Stoffel M.H. Heim R.C. Skoda Defective STAT signaling by the leptin receptor in diabetic mice Proc Natl Acad Sci USA 93 1996 6231 6235
    • (1996) , pp. 6231-6235
    • Ghilardi, N1    Ziegler, S2    Wiestner, A3    Stoffel, R4    Heim, M.H.5    Skoda, R.C.6
  • 47
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • W.A. Banks A.J. Kastin W Huang J.B. Jaspan L.M. Maness Leptin enters the brain by a saturable system independent of insulin Peptides 17 1996 305 311
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W3    Jaspan, J.B.4    Maness, L.M.5
  • 48
    • 0028117163 scopus 로고
    • Cytokine signal transduction
    • T Kishimoto T Taga S Akira Cytokine signal transduction Cell 76 1994 253 262
    • (1994) Cell , vol.76 , pp. 253-262
    • Kishimoto, T1    Taga, T2    Akira, S3
  • 49
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • H.C. Heldin Dimerization of cell surface receptors in signal transduction Cell 80 1995 213 223
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, H.C.1
  • 50
    • 0030183048 scopus 로고    scopus 로고
    • Ligand-induced dimerization of growth factor receptors: variations on the theme
    • H.C. Heldin A Ostman Ligand-induced dimerization of growth factor receptors: variations on the theme Cytokine & Growth Factor Reviews 7 1996 3 10
    • (1996) Cytokine & Growth Factor Reviews , vol.7 , pp. 3-10
    • Heldin, H.C.1    Ostman, A2
  • 51
    • 0028845212 scopus 로고
    • Cytokine receptor signaling
    • J.N. Ihle Cytokine receptor signaling Nature 377 1995 591 594
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 52
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • H Baumann K.K. Morella D.W. White M Dembski P.S. Bailon H Kim C.F. Lai L.A. Tartaglia The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors Proc Natl Acad Sci USA 93 1996 8374 8378
    • (1996) , pp. 8374-8378
    • Baumann, H1    Morella, K.K.2    White, D.W.3    Dembski, M4    Bailon, P.S.5    Kim, H6    Lai, C.F.7    Tartaglia, L.A.8
  • 53
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • C Vaisee J.L. Halaas C.M. Horvath J.E. Darnell Jr M Stoffel J.M. Friedman Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice Nat Genet 14 1996 95 97
    • (1996) Nat Genet , vol.14 , pp. 95-97
    • Vaisee, C1    Halaas, J.L.2    Horvath, C.M.3    Darnell, J.E.4    Stoffel, M5    Friedman, J.M.6
  • 55
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of mouse STATI gene results in compromised innate immunity to viral defense
    • J.E. Durbin R Hackenmiller M.C. Simon D.E. Levy Targeted disruption of mouse STATI gene results in compromised innate immunity to viral defense Cell 84 1996 443 450
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R2    Simon, M.C.3    Levy, D.E.4
  • 58
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating the response to IL-4 and for the development of Th2 cells
    • M.H. Kaplan U Schindler S.T. Smiley M.J. Grusby Stat6 is required for mediating the response to IL-4 and for the development of Th2 cells Immunity 4 1996 313 319
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U2    Smiley, S.T.3    Grusby, M.J.4
  • 59
    • 85114536428 scopus 로고    scopus 로고
    • White DW, Morella KK, Devos R, Baumann H, Tartaglia LA. Leptin receptor (OB-R) signaling: cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem in press.
  • 60
    • 0029900899 scopus 로고    scopus 로고
    • Reflections on STAT3, STAT5 and STAT6 as fat STATs
    • J.E. Darnell Reflections on STAT3, STAT5 and STAT6 as fat STATs Proc Natl Acad Sci USA 93 1996 6221 6224
    • (1996) , pp. 6221-6224
    • Darnell, J.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.