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Volumn 82, Issue 9, 1997, Pages 2771-2776

Leptin and clinical medicine: A new piece in the puzzle of obesity

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN;

EID: 85047677586     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.9.4224     Document Type: Review
Times cited : (148)

References (77)
  • 2
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • Coleman DL. 1978 Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 14:141-148.
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 3
    • 77957216320 scopus 로고
    • Fatty, a new mutation in the rat
    • Zucker LM, Zucker TF. 1961 Fatty, a new mutation in the rat. J Hered. 52:275-278.
    • (1961) J Hered. , vol.52 , pp. 275-278
    • Zucker, L.M.1    Zucker, T.F.2
  • 4
    • 0025627770 scopus 로고
    • Fat (fat) and tubby (tub): Two autosomal recessive mutations causing obesity syndromes in the mouse
    • Coleman DL, Eicher EM. 1990 Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J Hered. 81:424-427.
    • (1990) J Hered. , vol.81 , pp. 424-427
    • Coleman, D.L.1    Eicher, E.M.2
  • 5
    • 0018756428 scopus 로고
    • Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis
    • Bray GA, York DA. 1979 Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev. 59:719-809.
    • (1979) Physiol Rev. , vol.59 , pp. 719-809
    • Bray, G.A.1    York, D.A.2
  • 6
    • 0029040210 scopus 로고
    • Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
    • Naggert JK, Fricker LD, Varlamov O, et al. 1995 Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet. 10:135-142.
    • (1995) Nat Genet. , vol.10 , pp. 135-142
    • Naggert, J.K.1    Fricker, L.D.2    Varlamov, O.3
  • 7
    • 84990756135 scopus 로고
    • Hypothalamic lesions and adiposity in the rat
    • Hetherington AW, Ranson SW. 1940 Hypothalamic lesions and adiposity in the rat. Anat Rec. 78:149-172.
    • (1940) Anat Rec. , vol.78 , pp. 149-172
    • Hetherington, A.W.1    Ranson, S.W.2
  • 8
    • 0026326384 scopus 로고
    • Obesity, a disorder of nutrient partitioning: The Mona Lisa hypothesis
    • Bray GA. 1991 Obesity, a disorder of nutrient partitioning: the Mona Lisa hypothesis. J Nutr. 121:1146-1162.
    • (1991) J Nutr. , vol.121 , pp. 1146-1162
    • Bray, G.A.1
  • 11
    • 0029086176 scopus 로고
    • Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats
    • Ogawa Y, Masuzaki H, Isse N, et al. 1995 Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest. 96:1647-52.
    • (1995) J Clin Invest. , vol.96 , pp. 1647-1652
    • Ogawa, Y.1    Masuzaki, H.2    Isse, N.3
  • 12
    • 0016149002 scopus 로고
    • Fatness as a determinant of minimum weight necessary for their maintenance or onset
    • Frische RE, McArthur JW. 1974 Fatness as a determinant of minimum weight necessary for their maintenance or onset. Science. 185:949-951.
    • (1974) Science , vol.185 , pp. 949-951
    • Frische, R.E.1    McArthur, J.W.2
  • 13
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter MA, Cullen MJ, Baker MB, et al. 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:540-543.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 14
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 15
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al. 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 17
    • 0025937117 scopus 로고
    • Reciprocal relation between the sympathetic nervous system and food intake
    • Bray GA. 1991 Reciprocal relation between the sympathetic nervous system and food intake. Brain Res Bull. 27:517-520.
    • (1991) Brain Res Bull. , vol.27 , pp. 517-520
    • Bray, G.A.1
  • 18
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine RV, Sinha MK, Heiman ML, et al. 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:292-295.
    • (1996) N Engl J Med. , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 19
    • 0007524724 scopus 로고    scopus 로고
    • Evidence of free and bound leptin in human circulation: Studies in lean and obese subjects and during short-term fasting
    • Sinha MK, Opentanova I, Ohannesian JP, et al. 1996 Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short-term fasting. J Clin Invest. 98:1277-1282.
    • (1996) J Clin Invest. , vol.98 , pp. 1277-1282
    • Sinha, M.K.1    Opentanova, I.2    Ohannesian, J.P.3
  • 20
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D. 1996 Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med. 2:589-593.
    • (1996) Nat Med. , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte, D.5
  • 21
    • 0030012248 scopus 로고    scopus 로고
    • Plasma leptin and insulin relationships in obese and nonobese humans
    • Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M. 1996 Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes. 45:695-698.
    • (1996) Diabetes , vol.45 , pp. 695-698
    • Dagogo-Jack, S.1    Fanelli, C.2    Paramore, D.3    Brothers, J.4    Landt, M.5
  • 22
    • 0029131574 scopus 로고
    • Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
    • Frederich RC, Lollmann B, Hamann A, et al. 1995 Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest. 96:1658-1663.
    • (1995) J Clin Invest. , vol.96 , pp. 1658-1663
    • Frederich, R.C.1    Lollmann, B.2    Hamann, A.3
  • 24
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, et al. 1995 Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1:1155-1161.
    • (1995) Nat Med. , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 25
    • 0029976373 scopus 로고    scopus 로고
    • Early and late stimulation of ob mRNA expression in meal-fed and overfed rats
    • Harris RBS, Ramsay TG, Smith SR, Bruch RC. 1996 Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. J Clin Invest. 97:2020-2026.
    • (1996) J Clin Invest. , vol.97 , pp. 2020-2026
    • Harris, R.B.S.1    Ramsay, T.G.2    Smith, S.R.3    Bruch, R.C.4
  • 26
    • 0029020677 scopus 로고
    • Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
    • Considine RV, Considine EL, Williams CJ, et al. 1995 Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest. 95:2986-2988.
    • (1995) J Clin Invest. , vol.95 , pp. 2986-2988
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3
  • 27
    • 0029893230 scopus 로고    scopus 로고
    • Mutation screening and identification of a sequence variation in the human ob gene coding region
    • Considine RV, Considine EL, Williams CJ, et al. 1996 Mutation screening and identification of a sequence variation in the human ob gene coding region. Biochem Biophys Res Commun. 220:735-739.
    • (1996) Biochem Biophys Res Commun. , vol.220 , pp. 735-739
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3
  • 28
    • 0029938057 scopus 로고    scopus 로고
    • Extreme obesity may be linked to markers flanking the human OB gene
    • Reed DR, Ding Y, Xu WZ, Cather C, Green ED, Price RA. 1996 Extreme obesity may be linked to markers flanking the human OB gene. Diabetes. 45:691-694.
    • (1996) Diabetes , vol.45 , pp. 691-694
    • Reed, D.R.1    Ding, Y.2    Xu, W.Z.3    Cather, C.4    Green, E.D.5    Price, R.A.6
  • 29
    • 0345335191 scopus 로고    scopus 로고
    • Indication for linkage of the human OB gene region with extreme obesity
    • Clement K, Garner C, Hager J, et al. 1996 Indication for linkage of the human OB gene region with extreme obesity. Diabetes. 45:687-690.
    • (1996) Diabetes , vol.45 , pp. 687-690
    • Clement, K.1    Garner, C.2    Hager, J.3
  • 30
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, Ob-R
    • Tartaglia LA, Dembski M, Weng X, et al. 1995 Identification and expression cloning of a leptin receptor, Ob-R. Cell. 83:1263-1271.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 31
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal spicing of the leptin receptor in diabetic mice
    • Lee G-H, Proenca R, Montez JM, et al. 1996 Abnormal spicing of the leptin receptor in diabetic mice. Nature. 379:632-635.
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.-H.1    Proenca, R.2    Montez, J.M.3
  • 32
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H, Charlat O, Tartaglia LA, et al. 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:491-495.
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3
  • 33
    • 9344241376 scopus 로고    scopus 로고
    • Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr)
    • Chua SC, Jr, White DW, Wu-Peng XS, et al. 1996 Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes. 45:1141-1143.
    • (1996) Diabetes , vol.45 , pp. 1141-1143
    • Chua Jr., S.C.1    White, D.W.2    Wu-Peng, X.S.3
  • 35
    • 0030137757 scopus 로고    scopus 로고
    • Leptin receptor missense mutation in the fatty Zucker rat
    • Phillips MS, Liu QY, Hammond HA, et al. 1996 Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet. 13:18-19.
    • (1996) Nat Genet. , vol.13 , pp. 18-19
    • Phillips, M.S.1    Liu, Q.Y.2    Hammond, H.A.3
  • 37
    • 0029086473 scopus 로고
    • Threading analysis suggests that the obese gene product may be a helical cytokine
    • Madej T, Boguski MS, Bryant SH. 1995 Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett. 373:13-18.
    • (1995) FEBS Lett. , vol.373 , pp. 13-18
    • Madej, T.1    Boguski, M.S.2    Bryant, S.H.3
  • 38
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H, Morella KK, White DW, et al. 1996 The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA. 93:8374-8378.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3
  • 39
    • 0029763177 scopus 로고    scopus 로고
    • The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals
    • Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, et al. 1996 The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes. 45:1446-1450.
    • (1996) Diabetes , vol.45 , pp. 1446-1450
    • Cusin, I.1    Rohner-Jeanrenaud, F.2    Stricker-Krongrad, A.3
  • 41
    • 0030965884 scopus 로고    scopus 로고
    • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
    • Emilsson V, Liu Y-L, Cawthorne MA, Morton NM, Davenport M. 1997 Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes. 46:313-316.
    • (1997) Diabetes , vol.46 , pp. 313-316
    • Emilsson, V.1    Liu, Y.-L.2    Cawthorne, M.A.3    Morton, N.M.4    Davenport, M.5
  • 44
    • 0029762615 scopus 로고    scopus 로고
    • Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
    • Mercer JG, Hoggard N, Williams LM, et al. 1996 Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol. 8:733-735.
    • (1996) J Neuroendocrinol. , vol.8 , pp. 733-735
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3
  • 45
    • 0030807358 scopus 로고    scopus 로고
    • Diet-induced obese mice develop peripheral, but not central, resistance to leptin
    • Van Heek M, Compton DS, France CF, et al. 1997 Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 99:385-390.
    • (1997) J Clin Invest. , vol.99 , pp. 385-390
    • Van Heek, M.1    Compton, D.S.2    France, C.F.3
  • 46
    • 0029816596 scopus 로고    scopus 로고
    • Effects of gender, body composition, and menopause on plasma concentrations of leptin
    • Rosenbaum M, Nicolson M, Hirsch J, et al. 1996 Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrmol Metab. 81:3424-3427.
    • (1996) J Clin Endocrmol Metab. , vol.81 , pp. 3424-3427
    • Rosenbaum, M.1    Nicolson, M.2    Hirsch, J.3
  • 48
    • 0029978426 scopus 로고    scopus 로고
    • Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects
    • Sinha MK, Ohannesian JP, Heiman ML, et al. 1996 Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest. 97:1344-1347.
    • (1996) J Clin Invest. , vol.97 , pp. 1344-1347
    • Sinha, M.K.1    Ohannesian, J.P.2    Heiman, M.L.3
  • 49
    • 0029021599 scopus 로고
    • Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
    • De Vos P, Saladin R, Auwerx J, Staels B. 1995 Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem. 270:15958-15961.
    • (1995) J Biol Chem. , vol.270 , pp. 15958-15961
    • De Vos, P.1    Saladin, R.2    Auwerx, J.3    Staels, B.4
  • 50
    • 0028972884 scopus 로고
    • Dexamethasone regulates obese expression in isolated rat adipocytes
    • Murakami T, Iida M, Shima K. 1995 Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem Biophys Res Commun. 214:1260-1267.
    • (1995) Biochem Biophys Res Commun. , vol.214 , pp. 1260-1267
    • Murakami, T.1    Iida, M.2    Shima, K.3
  • 51
    • 0030071310 scopus 로고    scopus 로고
    • Differential expression of ob mRNA in rat adipose tissues in response to insulin
    • Zheng D, Jones JP, Usala SJ, Dohm GL. 1996 Differential expression of ob mRNA in rat adipose tissues in response to insulin. Biochem Biophys Res Commun. 218:434-437.
    • (1996) Biochem Biophys Res Commun. , vol.218 , pp. 434-437
    • Zheng, D.1    Jones, J.P.2    Usala, S.J.3    Dohm, G.L.4
  • 52
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin R, De Vos P, Guerre-Millo M, et al. 1995 Transient increase in obese gene expression after food intake or insulin administration. Nature. 377:527-529.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 53
    • 0029078449 scopus 로고
    • Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
    • MacDougald OA, Hwang CS, Fan H, Lane MD. 1995 Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA. 92:9034-9037.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9034-9037
    • MacDougald, O.A.1    Hwang, C.S.2    Fan, H.3    Lane, M.D.4
  • 55
    • 0029823153 scopus 로고    scopus 로고
    • Effects of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insulin-resistant Pima Indians
    • Pratley RE, Nicolson M, Bogardus C, Ravussin E. 1996 Effects of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insulin-resistant Pima Indians. J Clin Endocrinol Metab. 81:4418-4421.
    • (1996) J Clin Endocrinol Metab. , vol.81 , pp. 4418-4421
    • Pratley, R.E.1    Nicolson, M.2    Bogardus, C.3    Ravussin, E.4
  • 56
    • 0029665017 scopus 로고    scopus 로고
    • Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro
    • Kolaczynski JW, Nyce MR, Considine RV, et al. 1996 Acute and chronic effect of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes. 45:699-701.
    • (1996) Diabetes , vol.45 , pp. 699-701
    • Kolaczynski, J.W.1    Nyce, M.R.2    Considine, R.V.3
  • 57
    • 0029166158 scopus 로고
    • Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice
    • Trayhurn P, Thomas MEA, Duncan JS, Rayner DV. 1995 Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett. 368:488-490.
    • (1995) FEBS Lett. , vol.368 , pp. 488-490
    • Trayhurn, P.1    Thomas, M.E.A.2    Duncan, J.S.3    Rayner, D.V.4
  • 58
    • 0029964871 scopus 로고    scopus 로고
    • Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves
    • Kolaczynski JW, Considine RV, Ohannesian J, et al. 1996 Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes. 45:1511-1515.
    • (1996) Diabetes , vol.45 , pp. 1511-1515
    • Kolaczynski, J.W.1    Considine, R.V.2    Ohannesian, J.3
  • 59
    • 0008347278 scopus 로고    scopus 로고
    • Entrainment of the diurnal variation in plasma leptin levels
    • Schoeller DA, Cella LK, Sinha M, Caro J. 1996 Entrainment of the diurnal variation in plasma leptin levels [Abstract]. Obes Res. 4(Suppl 1):38S.
    • (1996) Obes Res. , vol.4 , Issue.1 SUPPL.
    • Schoeller, D.A.1    Cella, L.K.2    Sinha, M.3    Caro, J.4
  • 60
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima RS, Prabakaran D, Mantzoros C, et al. 1996 Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-252.
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 61
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with human recombinant leptin
    • Chehab FF, Lim ME, Lu R. 1996 Correction of the sterility defect in homozygous obese female mice by treatment with human recombinant leptin. Nat Genet. 12:318-320.
    • (1996) Nat Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 62
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • Chehab FF, Mounzih K, Lu R, Lim ME. 1997 Early onset of reproductive function in normal female mice treated with leptin. Science. 275:88-90.
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzih, K.2    Lu, R.3    Lim, M.E.4
  • 63
    • 0029953957 scopus 로고    scopus 로고
    • Leptin is a metabolic signal to the reproductive system
    • Barash IA, Cheung CC, Weigle DS, et al. 1996 Leptin is a metabolic signal to the reproductive system. Endocrinology. 137:3144-3147.
    • (1996) Endocrinology , vol.137 , pp. 3144-3147
    • Barash, I.A.1    Cheung, C.C.2    Weigle, D.S.3
  • 64
    • 70449255388 scopus 로고
    • The effects of lesions in the hypothalamus in parabiotic rats
    • Hervey GR. 1959 The effects of lesions in the hypothalamus in parabiotic rats. J Physiol. 145:336-356.
    • (1959) J Physiol. , vol.145 , pp. 336-356
    • Hervey, G.R.1
  • 65
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. 1986 Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 7:1189-1192.
    • (1986) Peptides , vol.7 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 66
    • 0028652667 scopus 로고
    • Specificity of hypothalamic peptides in the control of behavioral and physiological processes
    • Leibowitz SF. 1994 Specificity of hypothalamic peptides in the control of behavioral and physiological processes. Ann NY Acad Sci. 739:12-35.
    • (1994) Ann NY Acad Sci. , vol.739 , pp. 12-35
    • Leibowitz, S.F.1
  • 67
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • Stephens TW, Basinski M, Bristow PK, et al. 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:530-532.
    • (1995) Nature , vol.377 , pp. 530-532
    • Stephens, T.W.1    Basinski, M.2    Bristow, P.K.3
  • 69
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson JC, Clegg KE, Palmiter RD. 1996 Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:415-418.
    • (1996) Nature , vol.381 , pp. 415-418
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 70
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz MW, Baskin DG, Bukowski TR, et al. 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:531-535.
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3
  • 73
    • 0024792988 scopus 로고
    • Experimental obesity: A homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system
    • Bray GA, York DA, Fisler JS. 1990 Experimental obesity: a homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system. Vit Horm. 45:1-125.
    • (1990) Vit Horm. , vol.45 , pp. 1-125
    • Bray, G.A.1    York, D.A.2    Fisler, J.S.3
  • 74
    • 9844251498 scopus 로고
    • Role of glucocorticoids in the development of obesity and diabetes in experimental animal models
    • York DA. 1993 Role of glucocorticoids in the development of obesity and diabetes in experimental animal models. Obes Res. 1:186-192.
    • (1993) Obes Res. , vol.1 , pp. 186-192
    • York, D.A.1
  • 75
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. 1996 Leptin enters the brain by a saturable system independent of insulin. Peptides. 17:305-311.
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 76
    • 15844410399 scopus 로고    scopus 로고
    • Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
    • Bai Y, Zhan S, Kim K-S, Lee J-K, Kim K-H. 1996 Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem. 271:13939-13942.
    • (1996) J Biol Chem. , vol.271 , pp. 13939-13942
    • Bai, Y.1    Zhan, S.2    Kim, K.-S.3    Lee, J.-K.4    Kim, K.-H.5
  • 77
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen B, Novick D, Rubinstein M. 1996 Modulation of insulin activities by leptin. Science. 274:1185-1188.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.