Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice

Endocrinology

Volumn 137, Issue 4, 1996, Pages 1497-1500

  Malik, Karl F ^a   Young III, W Scott ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; LEPTIN; PLASMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APPETITE; ARTICLE; BINDING SITE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; DIABETES MELLITUS; FEEDING BEHAVIOR; LEPTOMENINX; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0029986894     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.4.8625929     Document Type: Article

References (11)

1. Pelleymounter, MA, Cullen, MJ, Baker, MB, Hecht, R, Winters, D, Boone, T, Collins, F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
2. Halaas, JL, Gjiwala, KS, Maffei, M, Cohen, SL, Chait, BT, Rabinowitz, D, Lallone, RL, Burley, SK, Friedman, JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
3. Campfield, LA, Smith, FJ, Guisez, Y, Devos, R, Burn, P 1995 Recombinant mouse OB protein:evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
4. Zhang, Y, Proenca, R, Maffei, M, Barone, M, Leopold, L, Friedman, JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
5. Stephens, TW, Basinski, M , Bristow, PK, Bue-Valleskey, JM, Burgett, SG, Craft, L, Hale, J, Hoffmann, J, Hsiung, HM, Kriauciunas, A, MacKellar, W, Rostec, PR, Schoner, B, Smith, D, Tinsley, FC, Zang, X-Y, Heiman, M 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377:530-532.
6. Blanar, MA, Rutter, WJ 1992 Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science 256:1018
7. 3H]Opioid receptors in rat brain. Brain Res. 179:255-270
8. Herkenham, M, Pert, CB 1982 Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality. J. Neurosci. 2:1129-1149
9. Malik, KF, Kim, J, Kim, P, Hartman, A, LeMoine, C, Young, WS, III 1994 Brn-4 POU protein: DNA binding preference and protein-protein interactions. Soc. Neurosci. Abstract 20:51
10. Nilsson, C, Lindvall-Axelsson, M, Owman, C 1992 Neuroendocrine regulatory mechanisms in the choroid plexus-cerebrospinal fluid system. Brain Res. Rev. 17:109-138
11. 2C serotonin receptor. Nature 374:542-546