Pre-mRNA splicing in the new millennium

Current Opinion in Cell Biology

Volumn 13, Issue 3, 2001, Pages 302-309

  Hastings, M L ^a   Krainer, A R ^a  

^a Watson School of Biological Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; MESSENGER RNA PRECURSOR; SERINE;

AMINO ACID SEQUENCE; EXON; GENETIC DISORDER; HUMAN; MODEL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FAMILY; REVIEW; RNA SPLICING; SITE DIRECTED MUTAGENESIS; SPLICEOSOME;

EID: 0035370845     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00212-X     Document Type: Review

References (54)

1. The question remains: Is the spliceosome a ribozyme?
2. Sorting out the complexity of SR protein functions
3. Exonic splicing enhancers: Mechanism of action, diversity and role in human genetic diseases
4. Protein diversity from alternative splicing: A challenge for bioinformatics and post-genome biology
5. Alternative pre-mRNA splicing: The logic of combinatorial control
6. Like attracts like: Getting things together in the nucleus
7. Pre-messenger RNA processing factors in the Drosophila genome
8. Analysis of the splicing machinery in fission yeast: A comparison with budding yeast and mammals
9. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
10. ATP can be dispensable for prespliceosome formation in yeast
11. Deletion of MUD2, the yeast homologue of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase
12. Functional recognition of the 5′ splice site by U4/U6.U5 tri-snRNP defines a novel ATP-dependent step in early spliceosome assembly
13. Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome
14. Role of adenine functional groups in the recognition of the 3′-splice-site AG during the second step of pre-mRNA splicing
15. RNA helicase dynamics in pre-mRNA splicing
16. Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
17. Pre-mRNA splicing in the absence of an SR protein RS domain
18. Selection of alternative 5′ splice sites: Role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNPA1
19. 3/6-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation
20. Dual utilization of an acceptor/donor site governs the alternative splicing of the IRF-3 gene
21. SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development
22. Functional characterization of SR and SR-related genes in Caenorhabditis elegans
23. Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development
24. The SR protein B52/SRp55 is essential for Drosophila development
25. Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor
26. Pre-mRNA splicing by the essential Drosophila protein B52: Tissue and target specificity
27. Multiple splicing defects in an intronic false exon
28. Evidence for a linear search in bimolecular 3′ splice site AG selection
29. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing
30. A yeast intronic splicing enhancer and Nam8p are required for Mer1p-activated splicing
31. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein
32. The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5′ splice site
33. An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5′ splice sites
34. A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing
35. Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing
36. An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein
37. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein
38. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
39. ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome
40. Frequent alternative splicing of human genes
41. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
42. RNA processing and human disease
43. Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1
44. Splicing defects in the ataxia-telangiectasia gene, ATM: Underlying mutations and consequences
45. A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes
46. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17
47. Animal models of spinal muscular atrophy
48. An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN
49. Htra2-β 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival of motor neuron 2 (SMN2)
50. Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients
51. Initial sequencing and analysis of the human genome
52. The sequence of the human genome
53. An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing
54. SC35 plays a role in T cell development and alternative splicing of CD45