The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site

Molecular and Cellular Biology

Volumn 20, Issue 17, 2000, Pages 6287-6299

  Del Gatto Konczak, F ^a   Bourgeois, C F ^a   Le Guiner, C ^a   Kister, L ^a   Gesnel, M C ^a   Stevenin, J ^a   Breathnach, R ^a  

^a INSTITUT DE BIOLOGIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COAT PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR; HYBRID PROTEIN; MESSENGER RNA PRECURSOR; REGULATOR PROTEIN; RNA BINDING PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ANIMAL CELL; ARTICLE; BACTERIOPHAGE; CONTROLLED STUDY; CROSS LINKING; EXON; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTRON; MAMMAL; NONHUMAN; OPERATOR GENE; PRIORITY JOURNAL; REGULATOR GENE; RNA SPLICING; SEQUENCE HOMOLOGY;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA, COMPLEMENTARY; EXONS; FUNGAL PROTEINS; GENE LIBRARY; HELA CELLS; HUMANS; INTRONS; MEMBRANE PROTEINS; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PLASMIDS; POLY(A)-BINDING PROTEINS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA SPLICING; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFECTION; ULTRAVIOLET RAYS;

ANIMALIA; MAMMALIA;

EID: 0033838148     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.17.6287-6299.2000     Document Type: Article

References (54)

1. Intronic sequence with both negative and positive effects on the regulation of alternative transcripts of the chicken beta tropomyosin transcripts
2. RNA-binding protein TIAR is essential for primordial germ cell development
3. Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR
4. Finding splice sites within a wilderness of RNA
5. Identification of a bidirectional splicing enhancer: Differential involvement of SR proteins in 5' or 3' splice site activation
6. An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing
7. The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers
8. Characterization and cloning of the human splicing factor 9G8: A novel 35 kDa factor of the serine/arginine protein family
9. The complex CD44 transcriptional unit; alternative splicing of three internal exons generates the epithelial form of CD44
10. Exon and intron sequences respecitively, repress and activate splicing, of a fibroblast growth factor receptor 2 alternative exon
11. The exon sequence TAGG can inhibit splicing
12. Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon
13. hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer
14. Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities
15. Luc7p, A novel yeast U1 snRNP protein with a role in 5' splice site recognition
16. Genetic and physical, interactions involving the yeast nuclear cap-binding complex
17. The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A
18. Identification and purification of a 62 000-dalton protein that binds specifically to the polypyrimidine tract of introns
19. Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA
20. The determinants of R NA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins
21. A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five hovel proteins
22. Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA
23. U1 snRNP targets an essential splicing factor U2AF65, to the 3' splice site by a network of interactions spanning the exon
24. Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element
25. A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs
26. Alternative splicing and programmed cell death
27. Identification and functional characterization of a TIA-1-I related nucleolysin
28. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules
29. The structure and function of proteins involved in mammalian pre-mRNA splicing
30. UBP1, A novel hnRNP-like protein that functions at multiple steps of higher plant nuclear pre-mRNA maturation
31. A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site
32. Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation
33. Expression of the CTL-associated protein TIA-1 during murine embryogenesis
34. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition
35. Combinatorial control of a neuronspecific exon
36. Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing
37. A sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA
38. Receptor specificity of the fibroblast growth factor family
39. Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection
40. Alternative splicing of E1A transcripts of adenovirus requires appropriate ionic conditions in vitro
41. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
42. A three-hybrid system to detect RNA-protein interactions in vivo
43. Split genes and RNA splicing
44. RNA binding specificity of hnRNP proteins: A subset bind to the 3' end of introns
45. The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death
46. Effects of SV40 transformation on the cytoskeleton and behavioral properties of human keratinocytes
47. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells
48. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis
49. Post-transcriptional regulation: The dawn of PTB
50. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability
51. A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44
52. SR proteins: A conserved family of pre-mRNA splicing factors
53. Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor
54. Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex