Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein

Molecular and Cellular Biology

Volumn 20, Issue 20, 2000, Pages 7463-7479

  Markovtsov, V ^a   Nikolic, J M ^a   Goldman, J A ^a   Turck, C W ^a   Chou, M Y ^a   Black, D L ^a  

^a Box 951662 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIMIDINE DERIVATIVE; REGULATOR PROTEIN; RIBONUCLEOPROTEIN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RNA SPLICING; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CHROMATOGRAPHY, AFFINITY; CLONING, MOLECULAR; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMAN; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ORGAN SPECIFICITY; PHYLOGENY; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTEIN BINDING; REGULATORY SEQUENCES, NUCLEIC ACID; RIBONUCLEOPROTEINS; RNA SPLICING; RNA, HETEROGENEOUS NUCLEAR; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033800453     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.20.7463-7479.2000     Document Type: Article

References (81)

1. Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation
2. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart
3. Control of 3' splice site choice in vivo by ASF/SF2 and hnRNP A1
4. Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro
5. Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro
6. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system
7. Mammalian pre-mRNA splicing factors
8. hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing
9. An intron splicing enhancer containing a G-rich repeat facilitates inclusion of a vertebrate micro-exon
10. Directing alternative splicing: Cast and scenarios
11. An intron element modulating 5' splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1
12. Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro
13. The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream
14. Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene
15. Single-step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction
16. hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells
17. Multisite binding and release of polypyrimidine tract binding protein during the regulation of c-src neural specific splicing
18. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators
19. hnRNP proteins and the biogenesis of mRNA
20. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif
21. A unique transactivation sequence motif is found in the carboxyl-terminal domain of the single-strand-binding protein FBP
22. 5' processing of tRNA precursors can be modulated by the human La antigen phosphoprotein
23. Tissue-specific splicing of two mutually exclusive exons of the chicken beta-tropomyosin pre-mRNA: Positive and negative regulations
24. hnRNP I, the polypyrimidine tract-binding protein: Distinct nuclear localization and association with hnRNAs
25. Nucleolin is a sequence-specific RNA-binding protein: Characterization of targets on pre-ribosomal RNA
26. Characterization of cDNAs encoding the polypyrimidine tract-binding protein
27. Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon
28. Splicing regulation in neurons: Tinkering with cells-pecific control
29. The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points
30. Polypyrimidine tract-binding protein interacts with HnRNP L
31. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors
32. Structural basis for recognition of the tra mRNA precursor by the sex-lethal protein
33. Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression
34. Control of alternative pre-mRNA splicing by distributed pentameric repeats
35. The function of multisite splicing enhancers
36. Elements regulating an alternatively spliced exon of the rat fibronectin gene
37. Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element
38. Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability
39. Cell type-specific expression of hnRNP proteins
40. Neuron-specific alternative splicing of nonmuscle myosin II heavy chain-B pre-mRNA requires a cis-acting intron sequence
41. Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro
42. hnRNP complexes: Composition, structure, and function
43. Sequence-specific RNA binding by a Nova KH domain: Implications for paraneoplastic disease and the fragile X syndrome
44. Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats
45. Regulation of alternative 3' splice site selection by constitutive splicing factors
46. Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation
47. SR proteins and splicing control
48. Protein-RNA interactions in the active center of transcription elongation complex
49. The hnRNP F protein: Unique primary structure, nucleic acid-binding properties, and subcellular localization
50. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF
51. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2
52. The packaging of pre-mRNA
53. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event
54. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer
55. Combinatorial control of a neuronspecific exon
56. A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon
57. Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA
58. Transcription processivity: Protein-DNA interactions holding together the elongation complex
59. Determination of functional domains in polypyrimidine-tract-binding protein
60. Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin
61. Characterization and molecular cloning of polypyrimidine tract-binding protein: A component of a complex necessary for pre-mRNA splicing
62. Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo
63. Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein
64. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
65. Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
66. RNA-binding proteins as regulators of gene expression
67. An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken beta-tropomyosin pre-mRNA
68. Trans splicing of mRNA precursors
69. Oligonucleotide binding specificities of the hnRNP C protein tetramer
70. Purified lupus antigen La recognizes an oligouridylate stretch common to the 3' termini of RNA polymerase III transcripts
71. Immunocytochemical localization of the neuron-specific form of the c-src gene product, pp60c-src(+), in rat brain
72. Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities
73. RNA binding specificity of hnRNP proteins: A subset bind to the 3' end of introns
74. Post-transcriptional regulation: The dawn of PTB
75. The SR protein family: Pleiotropic functions in pre-mRNA splicing
76. RNA recognition by RNP proteins during RNA processing
77. Regulation of pre-mRNA splicing in metazoa
78. Alternative pre-mRNA splicing
79. Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs
80. Isolation of a mammalian homologue of a fission yeast differentiation regulator
81. Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB