SC35 plays a role in T cell development and alternative splicing of CD45

Molecular Cell

Volumn 7, Issue 2, 2001, Pages 331-342

  Wang, Huan You ^a,b   Xu, Xiangdong ^a   Ding, Jian Hua ^a   Bermingham Jr , John R ^c   Fu, Xiang Dong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MCLAUGHLIN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; PROTEIN SC35; PROTEIN TYROSINE PHOSPHATASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL MATURATION; GENE DELETION; MOUSE; NONHUMAN; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMALIA; VERTEBRATA;

EID: 0035106072     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00181-2     Document Type: Article

References (59)

1. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells
2. Changes in CD45 isoform expression accompany antigen-induced murine T cell activation
3. CD45-null transgenic mice reveal apositive regulatory role for CD45 in early thymocytes development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
4. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factor
5. Characterization and cloning of the human splicing factor 9G8: A novel 35 kD factor of the serine-arginine protein family
6. Developmental expression of CD45 alternative splicing in murine T cells
7. Specific CD45 isoforms differentially regulate T cell receptor signaling
8. Natural and engineered disorders of lymphocytes development
9. Specific commitment of different pre-mRNAs to splicing by single SR proteins
10. The superfamily of arginine-serine-rich splicing factors
11. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35
12. General splicing factors SF2/ASF and SC35 have equivalent activities in vitro, and both affects 5′ and 3′ splice site selection
13. The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A
14. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
15. A protein factor, ASF, controls alternative splicing of SV40 early pre-mRNA in vitro
16. Sorting out the complexity of SR protein functions
17. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
18. Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations
19. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination
20. Rapid, reversible staining of Northern blots prior to hybridization
21. Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors
22. Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20
23. Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
24. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice
25. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phophatase-deficient mice
26. T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45
27. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites
28. The structure and function of proteins involved in mammalian pre-mRNA splicing
29. SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation
30. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
31. Functional characterization of SR and SR-related genes in Caenorhabditis elegans
32. A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras
33. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge
34. Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development
35. SR proteins and splicing control
36. Recent advances in gene mutagenesis in genetically engineered animals
37. Profound block in thymocyte development in mice lacking p56lck
38. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
39. RAG-1-deficient mice have no mature B and T lymphocytes
40. lck by the leukocyte common antigen (CD45)
41. Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection
42. Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro
43. An analysis of alternative spliced CD45 mRNA transcripts during T cell maturation in humans
44. Spliceosome assembly
45. Alternative use of 5′ exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages
46. Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA
47. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors
48. CD45 specifically modulates binding of lck to a phosphopeptide encompassing the negative regulatory tyrosine of lck
49. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
50. Several mRNAs with variable 3′ untranslated regions and different stability encode the human PR264/SC35 splicing factor
51. Regulation of alternative splicing of CD45 by antagonistic effects of SR protein splicing factors
52. Positive and negative regulation of Src-family membrance kinases by CD45
53. B-cell variant of mouse T200 (Ly-5): Evidence for alternative mRNA splicing
54. CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development
55. The SR protein family: Pleiotropic functions in pre-mRNA splicing
56. A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon
57. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V
58. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability
59. SR proteins: A conserved family of pre-mRNA splicing factors