Analyses of TCR(B) rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: Implications for the role of DNA-dependent protein kinase in V(D)J recombination

Journal of Immunology

Volumn 164, Issue 3, 2000, Pages 1416-1424

  Shin, Euy Kyun ^a   Rijkers, Tonnie ^b   Pastink, Albert ^b   Meek, Katheryn ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; ENDONUCLEASE; PROTEIN KINASE; SIGNAL PEPTIDE; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; DNA POLYMERASE; INTEGRASE; INTEGRON INTEGRASE INTI1; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN SERINE THREONINE KINASE; RECOMBINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMBINED IMMUNODEFICIENCY; DNA REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; ENZYME ACTIVITY; GENE REARRANGEMENT; GENE SEQUENCE; HYPOTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE; ALLELE; ANIMAL; CELL LINE; CODON; DRUG ANTAGONISM; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETIC RECOMBINATION; GENETICS; HORSE; IMMUNOLOGY; INTRON; MUTATION; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE;

ALLELES; ANIMALS; CATALYTIC DOMAIN; CELL LINE; CODON; DNA NUCLEOTIDYLTRANSFERASES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HORSES; INTEGRASES; INTRONS; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINASES; RECOMBINATION, GENETIC; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0034132349     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.3.1416     Document Type: Article

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