Biological basket weaving: Formation and function of clathrin-coated vesicles

Annual Review of Cell and Developmental Biology

Volumn 17, Issue , 2001, Pages 517-568

  Brodsky, F M ^a   Chen, C Y ^a   Knuehl, C ^a   Towler, M C ^a   Wakeharn, D E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adaptor; Cytoskeleton; Endocytosis; Secretion; Sorting

Indexed keywords

ADAPTOR PROTEIN; ANKYRIN; BETA ARRESTIN; CLATHRIN; DYNAMIN; HEAT SHOCK PROTEIN 70; INTERSECTIN; REGULATOR PROTEIN; SYNAPTOTAGMIN;

BINDING AFFINITY; BINDING KINETICS; CELL ACTIVITY; CELL FUNCTION; CELL MEMBRANE; CELL POLARITY; CONFERENCE PAPER; CORRELATION FUNCTION; DELETION MUTANT; GOLGI COMPLEX; HUMAN; IMMUNE SYSTEM; MOLECULAR BIOLOGY; MOLECULAR EVOLUTION; MUSCLE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CARRIER PROTEINS; CELL POLARITY; CLATHRIN; CLATHRIN-COATED VESICLES; COATED PITS, CELL-MEMBRANE; CYTOSKELETON; ENDOCYTOSIS; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUSCLE, SKELETAL; NEURONS; PROTEIN TRANSPORT;

EID: 0035184233     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.17.1.517     Document Type: Conference Paper

References (305)

1. Predominance of clathrin light chain LCb correlates with the presence of a regulated secretory pathway
2. Alteration of clathrin light chain expression by transfection and gene disruption
3. Auxilin, a newly identified clathrin-associated protein in coated vesicles from bovine brain
4. Src-mediated tyrosine phosphorylation of dynamin is required for β2-adrenergic receptor internalization and mitogen-activated protein kinase signaling
5. Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms
6. ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells
7. Defining protein interactions with yeast actin in vivo
8. The caveolae membrane system
9. Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts
10. Coupled inositide phosphorylation and phospholipase D activation initiates clathrin-coat assembly on lysosomes
11. Direct and GTP-dependent interaction of ADP-ribosylation factor 1 with clathrin adaptor protein AP-1 on immature secretory granules
12. Clathrin function in yeast endocytosis
13. Traffic COPs of the early secretory pathway
14. NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking
15. Self-association of the plasma membrane-associated clathrin assembly protein AP-2
16. AP-2/Eps15 interaction is required for receptor-mediated endocytosis
17. Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling
18. The protein data bank
19. A selective transport route from Golgi to late endosomes that requires the yeast GGA proteins
20. Clathrin assembly involves a light chain-binding region
21. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
22. A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi
23. T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: Evidence for a protein kinase C-independent staurosporine-sensitive step
24. Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4
25. Living with clathrin: Its role in intracellular membrane traffic
26. New fashions in vesicle coats
27. Clathrin
28. Clathrin light chains: Arrays of protein motifs that regulate coated vesicle dynamics
29. An internalization-competent influenza hemagglutinin mutant causes the redistribution of AP-2 to existing coated pits and is colocalized with AP-2 in clathrin free clusters
30. The Hsp70 and Hsp60 chaperone machines
31. Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brand and around T tubules in skeletal muscle
32. Adaptor self-aggregation, adaptor-receptor recognition and binding of α-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits
33. Epsin is an EH domain-binding protein implicated in clathrin-mediated endocytosis
34. Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
35. A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae
36. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization
37. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
38. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole
39. Phosphoinositides in membrane traffic at the synapse
40. Essential role of phosphoinositide metabolism in synaptic vesicle recycling
41. Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15
42. Spatially regulated recruitment of clathrin to the plasma membrane during capping and cell translocation
43. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
44. A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals
45. Structure and Asn-Pro-Phe binding pocket of the Eps 15 homology domain
46. Molecular mechanism of NPF recognition by EH domains
47. Identification of the major synaptojanin-binding proteins in brain
48. Association of the AP-3 adaptor complex with clathrin
49. AP-4, a novel protein complex related to clathrin adaptors
50. AP-3: An adaptor-like protein complex with ubiquitous expression
51. GGAs: A family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex
52. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the β3A subunit of the AP-3 adaptor
53. a to stimulate ATP hydrolysis
54. The clathrin endocytic pathway in viral infection
55. The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor
56. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites
57. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family
58. Floating the raft hypothesis for immune receptors: Access to rafts controls receptor signaling and trafficking
59. An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles
60. The actin-binding protein Hip1R binds clathrin and functions together with clathrin in the early stage of endocytosis
61. Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites
62. Pumping iron: The strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor
63. Genetic dissection of sperm individualization in Drosophila melanogaster
64. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
65. SCAMP1 function in endocytosis
66. Binding of AP2 to sorting signals is modulated by AP2 phosphorylation
67. Evidence that dynamin-2 functions as a signal-transducing GTPase
68. Three-dimensional structure of the ATPase fragment of a 70 K heat-shock cognate protein
69. Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein
70. Endocytosis proteins and cancer: A potential link?
71. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells
72. Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes
73. Tyrosine phosphorylation is required for actin-based motility of vaccinia but not Listeria or Shigella
74. Actin assembly plays a variable, but not obligatory role in receptor-mediated endocytosis in mammalian cells
75. In polarized MDCK cells basolateral vesicles arise from clathrin-γ-adaptin-coated domains on endosomal tubules
76. A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 α subunit. Implications for the endocytic pathway
77. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits
78. Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding
79. Spatial control of coated-pit dynamics in living cells
80. The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking
81. The β1 and β2 subunits of the AP complexes are the clathrin coat assembly components
82. DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast
83. Reconstitution of clathrin-independent endocytosis at the apical domain of permeabilized MDCK II cells: Requirement for a Rho-family GTPase
84. The role of endosomes and lysosomes in MHC class II functioning
85. Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis
86. Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain
87. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
88. Complete reconstitution of clathrin basket formation with recombinant protein fragments: Adaptor control of clathrin self-assembly
89. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells
90. Direct interaction of the 170 kDa isoform of synaptojanin 1 with clathrin and with the clathrin adaptor AP-2
91. ATP- and cytosol-dependent release of adaptor proteins from clathrin-coated vesicles: A dual role for Hsc70
92. AP180 and AP-2 interact directly in a complex that cooperatively assembles clathrin
93. Mutations in synaptojanin disrupt synaptic vesicle recycling
94. AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifs
95. Effects of cytoplasmic acidification on clathrin lattice morphology
96. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation
97. Deep-etch visualization of proteins involved in clathrin assembly
98. Deep-etch visualization of 27S clathrin: A tetrahedral tetramer
99. Deep-etch view of clathrin assembly
100. The role of dynamin and its binding partners in coated pit invagination and scission
101. Dynamin and its role in membrane fusion
102. Characterization of a fourth adaptorrelated protein complex
103. A family of proteins with γ-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome
104. The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains
105. Disruption of the clathrin heavy chain-like gene (CLTCL) associated with features of DGS/VCFS: A balanced (21;22)(p12;q11) translocation
106. Receptor-mediated endocytosis is sensitive to antibodies against the uncoating ATPase (hsc70)
107. 5-HT and cAMP induce the formation of coated pits and vesicles and increase the expression of clathrin light chain in sensory neurons of aplysia
108. Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast
109. Sac phosphatase domain proteins
110. Lipids, lipid modification and lipid-protein interaction in membrane budding and fission - Insights from the roles of endophilin A 1 and synaptophysin in synaptic vesicle endocytosis
111. Epsin 1 undergoes nuclesocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocyfic leukemia Zn(2)+ finger protein (PLZF)
112. Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
113. GAK: A cyclin G associated kinase contains a tensin/auxilin-like domain
114. The "vesicle in a basket." A morphological study of the coated vesicle isolated from the nerve endings of the guinea pig brain, with special reference to the mechanism of membrane movements
115. Clathrin-coated vesicles: Isolation, dissociation, and factor-dependent reassociation of clathrin baskets
116. The J-domain family and the recruitment of chaperone power
117. The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse tum conformation
118. Adaptors for clathrin-mediated traffic
119. Clathrin
120. Three ways to make a vesicle
121. Clathrin heavy chain: Molecular cloning and complete primary sequence
122. Immunoelectron microscopic evidence for the extended conformation of light chains in clathrin trimers
123. Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibire
124. Molscript - A program to produce both detailed and schematic plots of protein structures
125. Kinesin and dynamin are required for post-Golgi transport of a plasma-membrane protein
126. Arrestin-clathrin interaction. Localization of the clathrin binding domain of nonvisual arrestins to the carboxyl terminus
127. Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic β-cells
128. Increased lysosome-related proteins in the skeletal muscles of distal myopathy with rimmed vacuoles
129. Expression of clathrin assembly protein AP180 in nonneuronal cells
130. Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway
131. Membrane rafts and signaling by the multichain immune recognition receptors
132. The interaction of β-arrestin with the AP-2 adaptor is required for the clustering of β2-adrenergic receptor into clathrin-coated pits
133. β2-Adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase
134. Binding of AP-1 Golgi adaptors to membranes requires phosphorylated cytoplasmic domains of the mannose 6-phosphate/insulin-like growth factor II receptor
135. Inhibition of phospholipase D by amphiphysins
136. Clathrin uncoating: Auxilin comes to life
137. Amphiphysin, a novel protein associated with synaptic vesicles
138. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation
139. Molecular interactions between dynamin and G-protein βγ-subunits in neuroendocrine cells
140. Clathrin-mediated endocytosis
141. A dominant negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II MHC pathway
142. A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network
143. Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs
144. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
145. Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2
146. The tumor suppressor. PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
147. Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity
148. A membrane-associated protein complex with selective binding to the clathrin coat adaptor AP1
149. A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis
150. GTPase activity of dynamin and resulting conformation change are essential for endocytosis
151. Protein sorting by tyrosine based signals: Adapting to the Ys and wherefores
152. Synaptotagmins in membrane traffic: Which vesicles do the tagmins tag?
153. The structural era of endocytosis
154. Stonins 2: An adaptor-like protein that interacts with components of the endocytic machinery
155. Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process
156. Human transferrin receptor internalization is partially dependent upon an aromatic amino acid in the cytoplasmic domain
157. A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits
158. Endocytosis: An assembly protein for clathrin cages
159. The dynamin family of mechanoenzymes: Pinching in new places
160. FAP52, a novel. SH3 domain-containing focal adhesion protein
161. Raster3d Version 2.0 - A program for photorealistic molecular graphics
162. μ1A-adaptin-deficient mice: Lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
163. A requirement for ankyrin binding to clathrin during coated pit budding
164. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin
165. Transferrin receptors promote the formation of clathrin lattices
166. Regulated migration of epidermal growth factor receptor from caveolae
167. All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis
168. Role of clathrin in the regulated secretory pathway of pancreatic β-cells
169. A conserved clathrin assembly motif essential for synaptic vesicle endocytosis
170. A role for the clathrin assembly domain of AP180 in synaptic vesicle endocytosis
171. High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70
172. Membrane traffic in polarized epithelial cells
173. Domain structure and intramolecular regulation of dynamin GTPase
174. end5, end6, and end7: Mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae
175. Functional organization of clathrin in coats: Combining electron cryomicroscopy and X-ray crystallography
176. A novel motor. KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex
177. Involvement of clathrin light chains in the pathology of Alzheimer's disease
178. Involvement of clathrin light chains in the pathology of Pick's disease: Implication for impairment of axonal transport
179. Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail
180. A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis
181. A di-leucine signal in the ubiquitin moiety: Possible involvement in ubiquitination-mediated endocytosis
182. Folding and trimerization of clathrin subunits at the triskelion hub
183. Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein
184. Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant μ2 subunit and its effects on endocytosis
185. β-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein
186. Dominant-interfering Hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo
187. Energetics of clathrin basket assembly
188. The AP-3 complex: A coat of many colours
189. Membrane traffic and cytokinesis
190. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
191. μ1B, a novel adaptor medium chain expressed in polarized epithelial cells
192. Clathrin in mitotic spindles
193. Nef - An adaptor adaptor?
194. Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein
195. A structural explanation for the recognition of tyrosine-based endocytotic signais
196. A third specificity-determining site in μ2 adaptin for sequences upstream of YxxΦ sorting motifs
197. A structural explanation for the binding of multiple ligands by the α-adaptin appendage domain
198. The structure and function of the β2-adaptin appendage domain
199. Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation
200. γ-synergin: An EH domain-containing protein that interacts with γ-adaptin
201. Caveolin-3 associates with developing T-tubules during muscle differentiation
202. A test of clathrin function in protein secretion and cell growth
203. Clathrin: A role in the intracellular retention of a Golgi membrane protein
204. Coated vesicles from pig brain: Purification and biochemical characterization
205. Clathrin, adaptors and sorting
206. Characterization of a new member of the human β-adaptin gene family from chromosome 22q12, a candidate meningioma gene
207. Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes
208. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
209. A novel structural model for regulation of clathrin function
210. Valosin-containing protein. VCP, is a ubiquitous clathrin-binding protein
211. Clathrin: Its role in receptor-mediated vesicular transport and specialized functions in neurons
212. The interaction of calmodulin with clathrin-coated vesicles, triskelions, and light chains
213. Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis
214. Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and over-expressed in Down's syndrome
215. The GGAs promote ARF-dependent recruitment of clathrin to the TGN
216. Syndapin isoforms participate in receptor-mediated endocytosis and actin organization
217. Molecular links between endocytosis and the actin cytoskeleton
218. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein
219. Identification and characterization of a nerve terminal-enriched amphiphysin isoform
220. Dileucine-based sorting signals bind to the β chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site
221. Pleckstrin homology domains: A common fold with diverse functions
222. Specificity within the EGF family/ErbB receptor family signaling network
223. The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain
224. PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins
225. Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: Effects of Brefeldin A and G-protein activators
226. Dap160, a neural-specific Eps15 homology and multiple SH3 domain-containing protein that interacts with Drosophila dynamin
227. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70
228. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module
229. Lipid regulators of membrane traffic through the Golgi complex
230. Yolk protein uptake in the oocyte of the mosquito aedes aegypti L
231. Ankyrins
232. BINI is a novel MYC-interacting protein with features of a tumour suppressor
233. Epidermal growth factor pathway substrate 15, Eps15
234. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
235. Role of coated vesicles, microfilaments, and calmodulin in receptor-mediated endocytosis by cultured B lymphoblastoid cells
236. Endocytic clathrin-coated pit formation is independent of receptor internalization signal levels
237. Numb is an endocytic protein
238. An enzyme that removes clathrin coats: Purification of an uncoating ATPase
239. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
240. Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network
241. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15
242. Garrotes, springs, ratchets, and whips: Putting dynamin models to the test
243. A clathrin-binding site in the hinge of the β2 chain of mammalian AP-2 complexes
244. A novel adaptor-related protein complex
245. SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
246. Characterization of the adaptor-related protein complex, AP3
247. GLUT4 - At the cross roads between membrane trafficking and signal transduction
248. Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor
249. Accessory factors in clathrin-dependent synaptic vesicle endocytosis
250. Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites
251. Clathrin coats at 21 Å resolution: A cellular assembly designed to recycle multiple membrane receptors
252. The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: Implications for leukaemogenesis
253. Clathrin proteins and recognition memory
254. Interaction of activated EGF receptors with coated pit adaptins
255. Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins
256. Cloning and initial characterization of human epsin 3, a novel matrix-induced keratinocyte specific transcript
257. A primer on vesicle budding
258. A novel class of clathrin-coated vesicles budding from endosomes
259. Acute cholesterol depletion inhibits clathrin-coated pit budding
260. Pathways for lipid antigen presentation by CD1 molecules: Nowhere for intracellular pathogens to hide
261. Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent SNARE complex interaction
262. Adaptor γ ear homology domain conserved in γ-adaptin and GGA proteins that interact with γ-synergin
263. Clathrin facilitates the internalization of seven transmembrane segment receptors for mating pheromones in yeast
264. The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae
265. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: Localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic
266. Peptide-in-groove interactions link target proteins to the β-propeller of clathrin
267. Atomic structure of clathrin: A beta propeller terminal domain joins an alpha linker
268. Crystal structure of the pleckstrin homology domain from dynamin
269. Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1
270. AP-2-containing clathrin coats assemble on mature lysosomes
271. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly
272. Biochemical dissection of AP-1 recruitment onto Golgi membranes
273. A mutant HeLa cell line suggests novel requirements for protease-activated receptor-1 phosphorylation and recruitment to clathrin-coated pits
274. Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation
275. Role of auxilin in uncoating clathrin-coated vesicles
276. Growth hormone receptor ubiquitination coincides with recruitment to clathrin-coated membrane domains
277. Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways
278. Synaptotagmin regulation of coated pit assembly
279. A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole
280. Molecular structures of proteins involved in vesicle coat formation
281. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
282. Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor
283. Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis
284. Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
285. Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis
286. Clathrin plays a novel role in the regulation of cell polarity, pseudopod formation, uropod stability and motility in Dictyostelium
287. Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction
288. The EH1 domain of Eps15 is structurally classified as a member of the S100 subclass of EF-hand-containing proteins
289. The amphiphysin family of proteins and their role in endocytosis at the synapse
290. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake
291. In vivo phosphorylation of adaptors regulates their interaction with clathrin
292. In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly
293. 100-kD proteins of Golgi and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties
294. Inositol lipid 5-phosphatases - Traffic signals and signal traffic
295. Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains
296. Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry
297. Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease
298. Clathrin self-assembly is mediated by a tandemly repeated superhelix
299. Clathrin self-assembly is regulated by three light chain residues controlling the formation of critical salt bridges
300. Adaptor complex-independent clathrin function in yeast
301. Tailoring uniform coats for synaptic vesicles during endocytosis
302. Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling
303. Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: Evidence for formation of nascent pits containing AP1 or AP2 but not clathrin
304. Structural analysis of substrate binding by the molecular chaperone DnaK
305. Early embryonic death of mice deficient in γ-adaptin