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0032578003
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Polarized trafficking of plasma membrane proteins: Emerging roles for coats, SNAREs, GTPases and their link to the cytoskeleton
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Aroeti B., Okhrimenko H., Reich V., Orzech E. Polarized trafficking of plasma membrane proteins: emerging roles for coats, SNAREs, GTPases and their link to the cytoskeleton. Biochim Biophys Acta. 1376:1998;57-90.
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New perspectives on mechanisms involved in generating epithelial cell polarity
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This is a clear and comprehensive review of epithelial-cell polarity.
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Yeaman C., Grindstaff K.K., Nelson W.J. New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev. 79:1999;73-98. This is a clear and comprehensive review of epithelial-cell polarity.
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Yeaman, C.1
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Catch the μ1B train to the basolateral surface
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A minireview focusing on adaptor proteins involved in basolateral sorting.
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Mostov K.E., ter Beest M.B.A., Chapin S.J. Catch the μ1B train to the basolateral surface. Cell. 99:1999;121-122. A minireview focusing on adaptor proteins involved in basolateral sorting.
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Mostov, K.E.1
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0033593332
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Interactions between the exocytic and endocytic pathways in polarized Madin Darby canine kidney cells
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•] these papers show that there are two routes for targeting of the pIgR (and possibly other proteins) from the TGN to the basolateral surface. One pathway is brefeldin A (BFA) sensitive, involves interaction with the AP1 adaptor, passes through endosomes, and is rapid. The other pathway is BFA insensitive, does not involve AP1, does not pass through endosomes, and is slow.
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•] these papers show that there are two routes for targeting of the pIgR (and possibly other proteins) from the TGN to the basolateral surface. One pathway is brefeldin A (BFA) sensitive, involves interaction with the AP1 adaptor, passes through endosomes, and is rapid. The other pathway is BFA insensitive, does not involve AP1, does not pass through endosomes, and is slow.
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Orzech, E.1
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Receptor-mediated transcytosis of IgA in MDCK cells via apical recycling endosomes
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In polarized MDCK cells basolateral vesicles arise from clathrin-gamma-adaptin-coated domains on endosomal tubules
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Futter C.E., Gibson A., Allchin E.H., Maxwell S., Ruddock L.J., Odorizzi G., Domingo D., Trowbridge I.S., Hopkins C.R. In polarized MDCK cells basolateral vesicles arise from clathrin-gamma-adaptin-coated domains on endosomal tubules. J Cell Biol. 141:1998;611-623.
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8
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15644371370
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Sorting mechanisms regulating membrane protein traffic in the apical transcytotic pathway of polarized MDCK cells
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Gibson A., Futter C.E., Maxwell S., Allchin E.H., Shipman M., Kraehenbuhl J.P., Domingo D., Odorizzi G., Trowbridge I.S., Hopkins C.R. Sorting mechanisms regulating membrane protein traffic in the apical transcytotic pathway of polarized MDCK cells. J Cell Biol. 143:1998;81-94.
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Gibson, A.1
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Domingo, D.7
Odorizzi, G.8
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Hopkins, C.R.10
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9
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0033525930
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The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions
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Mathematical modeling was used to show that polarized sorting occurs in at least two compartments. A large population of transferrin recycles from an early compartment back to the plasma membrane.
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Sheff D.R., Daro E.A., Hull M., Mellman I. The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions. J Cell Biol. 145:1999;123-139. Mathematical modeling was used to show that polarized sorting occurs in at least two compartments. A large population of transferrin recycles from an early compartment back to the plasma membrane.
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J Cell Biol
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Sheff, D.R.1
Daro, E.A.2
Hull, M.3
Mellman, I.4
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10
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0033621149
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A tubular endosomal fraction from rat liver: Biochemical evidence of receptor sorting by default
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A subcellular fraction was isolated from rat liver that was enriched in the CE. Analysis of the density of TfR and pIgR in these membranes suggests that these receptors are not sorted from each other during movement from the basolateral early endosomes to the CE.
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Vergés M., Havel R.J., Mostov K.E. A tubular endosomal fraction from rat liver: Biochemical evidence of receptor sorting by default. Proc Natl Acad Sci USA. 18:1999;10 146-10 151. A subcellular fraction was isolated from rat liver that was enriched in the CE. Analysis of the density of TfR and pIgR in these membranes suggests that these receptors are not sorted from each other during movement from the basolateral early endosomes to the CE.
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(1999)
Proc Natl Acad Sci USA
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Vergés, M.1
Havel, R.J.2
Mostov, K.E.3
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11
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0034139848
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Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling
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A comprehensive light microscopic study of sorting in the transcytotic pathway. This group, by rigorous quantitative methods, showed that Tf and IgA are not sorted during movement from BEE to CE, but are sorted to give a five-fold enrichment of IgA over Tf in the apical recycling endosome (ARE).
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Brown P.S., Wang E., Aroeti B., Chapin S.J., Mostov K.E., Dunn K.W. Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. Traffic. 1:2000;124-140. A comprehensive light microscopic study of sorting in the transcytotic pathway. This group, by rigorous quantitative methods, showed that Tf and IgA are not sorted during movement from BEE to CE, but are sorted to give a five-fold enrichment of IgA over Tf in the apical recycling endosome (ARE).
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(2000)
Traffic
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, pp. 124-140
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Brown, P.S.1
Wang, E.2
Aroeti, B.3
Chapin, S.J.4
Mostov, K.E.5
Dunn, K.W.6
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12
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0034084289
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Sorting of membrane and fluid at the apical pole of polarized MDCK cells
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in press. Shows that apical endocytosed fluid and IgA are segregated in the AEE, with IgA being delivered to the ARE in a microtubule-dependent process.
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Leung S-M., Ruiz W.G., Apodaca G. Sorting of membrane and fluid at the apical pole of polarized MDCK cells. Mol Biol Cell. 2000;. in press. Shows that apical endocytosed fluid and IgA are segregated in the AEE, with IgA being delivered to the ARE in a microtubule-dependent process.
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Mol Biol Cell
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Leung, S.-M.1
Ruiz, W.G.2
Apodaca, G.3
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13
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0034208649
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Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome
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This paper provides quantitation of intracellular pH in the various endosomal compartments in MDCK cell.
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Wang E., Brown P.S., Aroeti B., Chapin S.J., Mostov K.E., Dunn K.D. Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. Traffic. 1:2000;480-493. This paper provides quantitation of intracellular pH in the various endosomal compartments in MDCK cell.
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Traffic
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Wang, E.1
Brown, P.S.2
Aroeti, B.3
Chapin, S.J.4
Mostov, K.E.5
Dunn, K.D.6
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14
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0033543763
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Identification of syntenin as a protein of the apical early endocytic compartment in Madin-Darby canine kidney cells
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Apical early endosomes are shown in this paper to be enriched in syntenin, which is thus the first marker identified for this compartment.
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Fialka I., Steinlein P., Ahorn H., Bock G., Burbelo P.D., Haberfellner M., Lottspeich F., Paiha K., Pasquali C., Huber L.A. Identification of syntenin as a protein of the apical early endocytic compartment in Madin-Darby canine kidney cells. J Biol Chem. 274:1999;26 233-26 239. Apical early endosomes are shown in this paper to be enriched in syntenin, which is thus the first marker identified for this compartment.
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Fialka, I.1
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Burbelo, P.D.5
Haberfellner, M.6
Lottspeich, F.7
Paiha, K.8
Pasquali, C.9
Huber, L.A.10
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15
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0032956506
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The subapical compartment: A novel sorting centre?
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A recent review on the subapical compartment and lipid trafficking, especially in polarized epithelial cell.
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van Ijzendoorn S.C., Hoekstra D. The subapical compartment: a novel sorting centre? Trends Cell Biol. 9:1999;144-149. A recent review on the subapical compartment and lipid trafficking, especially in polarized epithelial cell.
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Van Ijzendoorn, S.C.1
Hoekstra, D.2
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0032547083
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Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells
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Hunziker W., Peters P.J. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. J Biol Chem. 273:1998;15 734-15 741.
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Hunziker, W.1
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0032498797
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Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells
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Zacchi P., Stenmark H., Parton R.G., Orioli D., Lim F., Giner A., Mellman I., Zerial M., Murphy C. Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. J Cell Biol. 140:1998;1039-1053.
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Zacchi, P.1
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Mellman, I.7
Zerial, M.8
Murphy, C.9
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18
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0032951298
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Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells
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Overexpression of wild-type and mutant forms of rabs 11 and 25 was used to show that these proteins are involved in traffic in the ARE and/or CE.
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Casanova J.E., Wang X., Kumar R., Bhartur S.G., Navarre J., Woodrum J.E., Altschuler Y., Ray G.S., Goldenring J.R. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 10:1999;47-61. Overexpression of wild-type and mutant forms of rabs 11 and 25 was used to show that these proteins are involved in traffic in the ARE and/or CE.
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Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis
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Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells
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Roush D.L., Gottardi C.J., Naim H.Y., Roth M.G., Caplan M.J. Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells. J Biol Chem. 273:1998;26 862-26 869.
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23
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0032692619
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A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells
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This landmark paper implicates μ1b as an adaptor that is sufficient for basolateral sorting of some proteins in epithelial cells.
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Fölsch H., Ohno H., Bonifacino J.S., Mellman I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell. 99:1999;189-198. This landmark paper implicates μ1b as an adaptor that is sufficient for basolateral sorting of some proteins in epithelial cells.
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Fölsch, H.1
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Correlative light-electron microscopy reveals the tubular-saccular ultrastructure of carriers operating between Golgi apparatus and plasma membrane
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Polishchuk R.S., Polishchuk E.V., Marra P., Alberti S., Buccione R., Luini A., Mironov A.A. Correlative light-electron microscopy reveals the tubular-saccular ultrastructure of carriers operating between Golgi apparatus and plasma membrane. J Cell Biol. 148:2000;45-58.
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Polishchuk, R.S.1
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Fanning A.S., Anderson J.M. Protein modules as organizers of membrane structure. Curr Opin Cell Biol. 11:1999;432-439.
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Which way is up?
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Peifer M., Tepass U. Which way is up? Nature. 403:2000;611-612.
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0033522488
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PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells
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Perego C., Vanoni C., Villa A., Longhi R., Kaech S.M., Frohli E., Hajnal A., Kim S.K., Pietrini G. PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells. EMBO J. 18:1999;2384-2393.
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Perego, C.1
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28
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0032514155
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Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells
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Lin S., Naim H.Y., Rodriguez A.C., Roth M.G. Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells. J Cell Biol. 142:1998;51-57.
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29
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0033179221
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Glycans in post-Golgi apical targeting: Sorting signals or structural props?
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This review critically lays out the evidence for and against a role for glycans in apical targeting, and it suggests that glycans may serve a structural role.
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Rodriguez-Boulan E., Gonzalez A. Glycans in post-Golgi apical targeting: sorting signals or structural props? Trends Cell Biol. 9:1999;291-294. This review critically lays out the evidence for and against a role for glycans in apical targeting, and it suggests that glycans may serve a structural role.
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Trends Cell Biol
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Rodriguez-Boulan, E.1
Gonzalez, A.2
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30
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0034695917
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A transmembrane segment determines the steady-state localization of an ion-transporting adenosine triphosphatase
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The H-K ATPase and the Na-K ATPase are highly similar, multitopic membrane proteins, which are located apically and basolaterally, respectively. An apical targeting signal was found in the fourth of the ten transmembrane segments of the H-K ATPase.
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Dunbar L.A., Aronson P., Caplan M.J. A transmembrane segment determines the steady-state localization of an ion-transporting adenosine triphosphatase. J Cell Biol. 148:2000;769-778. The H-K ATPase and the Na-K ATPase are highly similar, multitopic membrane proteins, which are located apically and basolaterally, respectively. An apical targeting signal was found in the fourth of the ten transmembrane segments of the H-K ATPase.
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J Cell Biol
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Dunbar, L.A.1
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Apical targeting in polarized epithelial cells: There's more afloat than rafts
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Looking at lipid rafts?
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A review of some important recent papers on the size and dynamics of rafts in cells.
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Jacobson K., Dietrich C. Looking at lipid rafts? Trends Cell Biol. 9:1999;87-91. A review of some important recent papers on the size and dynamics of rafts in cells.
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0032931988
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Extraction of cholesterol with methyl-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
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Rodal S.K., Skretting G., Garred Ø., Vilhardt F., van Deurs B., Sandvig K. Extraction of cholesterol with methyl-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 10:1999;961-974.
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35
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Subtil A., Gaidarov I., Kobylarz K., Lampson M.A., Keen J.H., McGraw T.E. Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc Natl Acad Sci USA. 96:1999;6775-6780.
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36
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0033606823
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N-Glycans mediate the apical sorting of a GPI-anchored, raft-associated protein in Madin-Darby canine kidney cells
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A GPI-anchored form of growth hormone was basolateral targeted. Addition of N-glycans to this conferred apical targeting.
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Benting J.H., Rietveld A.G., Simons K. N-Glycans mediate the apical sorting of a GPI-anchored, raft-associated protein in Madin-Darby canine kidney cells. J Cell Biol. 146:1999;313-320. A GPI-anchored form of growth hormone was basolateral targeted. Addition of N-glycans to this conferred apical targeting.
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Benting, J.H.1
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37
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0034003908
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Detergent-insoluble GPI-anchored proteins are apically sorted in Fischer rat thyroid cells, but interference with cholesterol or sphingolipids differentially affects detergent insolubility and apical sorting
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Lipardi C., Nitsch L., Zurzolo C. Detergent-insoluble GPI-anchored proteins are apically sorted in Fischer rat thyroid cells, but interference with cholesterol or sphingolipids differentially affects detergent insolubility and apical sorting. Mol Biol Cell. 11:2000;531-542.
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VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells
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Cheong K.H., Zacchetti D., Schneeberger E.E., Simons K. VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells. Proc Natl Acad Sci USA. 96:1999;6241-6248.
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0345683542
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The MAL proteolipid is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin in Madin-Darby canine kidney cells
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Puertollano R., Martin-Belmonte F., Millan J., de Marco M.C., Albar J.P., Kremer L., Alonso M.A. The MAL proteolipid is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin in Madin-Darby canine kidney cells. J Cell Biol. 145:1999;141-151.
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Puertollano, R.1
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40
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0034614944
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Influenza M2 proton channel activity selectively inhibits trans-Golgi network release of apical membrane and secreted proteins in polarized Madin-Darby canine kidney cells
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