Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease

Neurobiology of Aging

Volumn 21, Issue 6, 2000, Pages 921-929

  Yao, Pamela J ^a   Weimer, Jill M ^a   O’Herron, Timothy M ^a   Coleman, Paul D ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; AP 2; Clathrin assembly protein; Endocytosis; Immunoblot analysis; Immunohistochemistry; Synaptic vesicle recycling

Indexed keywords

ADAPTOR PROTEIN; CLATHRIN; TRANSCRIPTION FACTOR AP 2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; AUTOPSY; CELL LINE; CEREBELLUM; CONTROLLED STUDY; FRONTAL CORTEX; GLIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AGED; AGED, 80 AND OVER; ANIMALS; CELL LINE; ENZYME INHIBITORS; FEMALE; FRONTAL LOBE; HUMANS; MALE; MICE; MIDDLE AGED; MONOMERIC CLATHRIN ASSEMBLY PROTEINS; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; ORGAN SPECIFICITY; PHOSPHOPROTEINS; REFERENCE VALUES; SYNAPSES;

EID: 0033638756     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(00)00228-1     Document Type: Article

References (30)

1. Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane
2. Expression and localization of α-adaptin isoforms
3. Composition of white matter bovine brain coated vesicles; evidence that several components influence beta-amyloid peptide to form oligomers and aggregates in vitro
4. Staging of Alzheimer's disease-related neurofibrillary changes
5. Conditionally immortalized neural cell lines; potential models for the study of neural cell function
6. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease; neuropathologic evidence for a mechanism of increased β-amyloiddogenesis
7. Endocytic pathway abnormalities precede amyloid b deposition in sporadic Alzheimer's disease and Down syndrome
8. Intraneuronal compartments of the amyloid precursor protein
9. Plasticity of hippocampal circuitry in Alzheimer's disease
10. Role of Drosophila α-adaptin in presynaptic vesicle recycling
11. AP180 and AP-2 interact directly in a complex that cooperatively assembles clathrin
12. Evidence for recycling of synaptic vesicle membrane protein in intact neurons
13. Diagnosis of Alzheimer's disease
14. Neuronal properties and trophic activities of immortalized hippocampal cells from embryonic and young adult mice
15. Clathrin-associated proteins of bovine brain coated vesicles
16. Trafficking of cell-surface beta-amyloid precursor protein; evidence that a sorting intermediate participates in synaptic vesicle recycling
17. Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling
18. Involvement of clathrin light chains in the pathology of Alzheimer's disease
19. Identification of the Alzheimer b/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells
20. Clathrin, adaptors and sorting
21. Neuronal protein NP185 in avian and murine cerebellum; expression during development and evidence for its presence in nerve endings
22. Clathrin coats-threads laid bare
23. Cloning of cDNAs encoding two related 100kD coated vesicle proteins (α-adaptins)
24. Clathrin-coated vesicle formation and protein sorting; an integrated process
25. Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue
26. Subunit interaction and function of clathrin-coated vesicle adaptors from the Golgi and the plasma membrane
27. Characterization of a novel synapse-specific protein. I. Developmental expression and cellular localization of the F11-20 protein and mRNA
28. Reduction of O-linked N-acetylglucosamine-modified assembly protein-3 in Alzheimer's disease
29. Reduced O-glycosylated clathrin assembly protein AP180; implication for synaptic vesicle recycling dysfunction in Alzheimer's disease
30. Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analyzed by immunohistochemistry