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note
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We thank A. Pelchen-Matthews for Fig. 1A, J. Heuser for Fig. 1B, and B. Pearse and C. Smith for Fig. 1C; T. Kirchhausen, F. Brodsky, P. Hwang, and T. de Beer for providing structural coordinates; D. Owen and P. Evans for help in assembling Fig. 2; and A. Pelchen-Matthews, N. Signoret, M.-J. Bijlmakers, and P. Wigge for critical comments on the manuscript. We apologize to those whose work we have not cited because of limits on space. The authors are supported by the UK Medical Research Council.
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