GLUT4 - At the cross roads between membrane trafficking and signal transduction

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Volumn 2, Issue 1, 2001, Pages 2-11

  Simpson, F ^a   Whitehead, J P ^a   James, D E ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Glucose transporter; Insulin action; Vesicle transport

Indexed keywords

CELLUBREVIN; GLUCOSE TRANSPORTER; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C ZETA; PROTEIN SERINE THREONINE KINASE; SNARE PROTEIN; SYNTAXIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; BASAL CELL; CELL MEMBRANE; CELL SURFACE; CHO CELL; CYTOSOL; ENDOSOME; EXOCYTOSIS; GLUCOGENESIS; GLUCOSE TRANSPORT; HYPOTHESIS; INSULIN RESPONSE; INTRACELLULAR TRANSPORT; MAMMAL; MEDICAL RESEARCH; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADIPOCYTES; ANIMALS; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INTRACELLULAR MEMBRANES; MODELS, BIOLOGICAL; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSPORT VESICLES;

EID: 0035106864     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.020102.x     Document Type: Review

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32. Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin
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35. Characterization of Munc-18c and Syntaxin 4 in 3T3-L1 adipocytes
36. Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins
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38. Biogenesis of synaptic vesicles in vitro
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41. A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts
42. The cytosolic C-terminus of the glucose transporter GLUT4 contains an acidic cluster endosomal targeting motif distal to the dileucine signal
43. Bi-cycling the furin pathway: From TGN localization to pathogen activation and embryogenesis
44. The amino terminus of insulin-responsive aminopeptidase causes Glut4 translocation in 3T3-L1 adipocytes
45. A synthetic peptide corresponding to the GLUT4 C-terminal cytoplasmic domain causes insulin-like glucose transport stimulation and GLUT4 recruitment in rat adipocytes
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48. An SH2 domain-containing 5′ inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement
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51. Contraction inhibits insulin-stimulated insulin receptor substrate-1 2-associated phosphoinositide 3-kinase activity, but not the protein kinase B activation or glucose uptake, in rat muscle
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56. A role for protein kinase Bb/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes
57. Expression of a constitutively active Akt Ser Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
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64. Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes
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67. Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ε) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat interchangeable effects of protein kinases C-ζ and C-λ
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70. Calmodulin antagonists inhibit insulin-stimulated GLUT4 (glucose transporter 4) translocation by preventing the formation of phosphatidylinositol 3,4,5-trisphosphate in 3T3-L1 adipocytes
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93. Insulin increase the association of Akt-2 with GLUT4-containing vesicles
94. Akt-2 binds to GLUT4-containing vesicles and phosphorylates their component proteins in response to insulin
95. Insulin-induced actin filament remodelling: Colocalisation with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes
96. Perinuclear localisation and insulin-responsiveness of GLUT4 requires a skeletal integrity in 3T3-L1 adipocytes
97. Synip: A novel insulin-regulated Syntaxin4 binding protein mediating GLUT4 translocation in adipocytes
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101. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin
102. Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes
103. Inhibition of insulin-induced GLUT4 translocation by Munc18c through interaction with syntaxin4 in 3T3-L1 adipocytes
104. Munc18c function is required for insulin-stimulated plasma membrane fusion of GLUT4 and insulin-responsive amino peptidase storage vesicles
105. Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes
106. Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2
107. Syntaxin 4, VAMP2, and/or VAMP3 cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes
108. Syntaxin 4 in 3T3-L1 adipocytes: Regulation by insulin and participation in insulin-dependent glucose transport
109. Functional studies in 3T3L1 cells support a role for SNARE proteins in insulin stimulation of GLUT4 translocation
110. Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 present
111. Botulinum E toxin light chain does not cleave SNAP-23 and only partially impairs insulin stimulation of GLUT4 translocation in 3T3-L1 cells
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117. 1-[N,O-Bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenyl-piperazine (KN-62), an inhibitor of calcium-dependent calmodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose muscle