GTPase activity of dynamin and resulting conformation change are essential for endocytosis

Nature

Volumn 410, Issue 6825, 2001, Pages 231-235

  Marks, Bruno ^a   Stowell, Michael H B ^a   Vallis, Yvonne ^a   Mills, Ian G ^a   Gibson, Adele ^b   Hopkins, Colin R ^b   McMahon, Harvey T ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN; GUANOSINE TRIPHOSPHATASE;

ANIMAL CELL; ARTICLE; CELL VACUOLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME CONFORMATION; FIBROBLAST; INTRACELLULAR TRANSPORT; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; COS CELLS; DROSOPHILA; DYNAMINS; ENDOCYTOSIS; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSFERRIN;

ANIMALIA;

EID: 0035826257     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35065645     Document Type: Article

References (29)

1. The dynamins: Redundant or distinct functions for an expanding family of related GTPases?
2. Functional diversity in the dynamin family
3. Dynamin self-assembly stimulates its GTPase activity
4. Is dynamin really a 'pinchase'?
5. Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis
6. Reversible alterations in the neuromuscular junctions of Drosophila melanogaster bearing a temperature-sensitive mutation, shibire
7. Possible temperature-dependent blockage of synaptic vesicle recycling induced by a single gene mutation in Drosophila
8. Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval
9. Mutations in human dynamin block an intermediate stage in coated vesicle formation
10. Effects of mutant rat dynamin on endocytosis
11. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
12. Tubular membrane invaginations coated by dynamin rings are induced by GTPγS in nerve terminals
13. Dynamin undergoes a GTP-dependent conformational change causing vesiculation
14. Generation of coated intermediates of clathrin-mediated endocytosis on protein-free liposomes
15. Nucleotide-dependent conformational changes in dynamin: Evidence for a mechanochemical molecular spring
16. Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis
17. Domain structure and intramolecular regulation of dynamin GTPase
18. Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism
19. Multiple distinct coiled-coils are involved in dynamin self-assembly
20. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: Implications for the mechanism of GTP hydrolysis
21. Transphosphorylation and G protein activation
22. Lipid nanotubes as substrates for helical crystallization of macromolecules
23. Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells
24. Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis
25. Essential role of the dynamin pleckstrin homology domain in receptor mediated endocytosis
26. A model for dynamin self-assembly based on binding between three different protein domains
27. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence
28. Amphiphysin heterodimers: Potential role in clathrin-mediated endocytosis
29. Crystal structure of the Amphiphysin-2 SH3 domain and its role in prevention of dynamin ring formation