Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium

Journal of Bone and Mineral Research

Volumn 12, Issue 2, 1997, Pages 228-233

  Bornefalk, Eva ^a   Ljunghall, Sverker ^a   Lindh, Erik ^a   Bengtson, Olof ^a   Johansson, Anna G ^a   Ljunggren, Östen ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTICLE; BONE REMODELING; CALCIUM BLOOD LEVEL; CALCIUM INTAKE; DIET RESTRICTION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN EXPERIMENT; HYPERCALCEMIA; MONONUCLEAR CELL; MULTIPLE MYELOMA; NORMAL HUMAN; OSTEOPOROSIS; POSTMENOPAUSE; TUMOR GROWTH;

ADMINISTRATION, ORAL; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SPACE; HUMANS; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; PARATHYROID HORMONE;

EID: 0031016187     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.2.228     Document Type: Article

References (36)

1. Roodman GD 1992 Interieukin-6: An osteotropic factor? J Bone Miner Res 7:475-478.
2. Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling. N Engl J Med 332:305-311.
3. Feyen JHM, Elford P, Di Padova FE, Trechsel U 1989 Interleukin-6 is produced by bone and modulated by parathyroid hormone. J Bone Miner Res 4:633-638.
4. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T 1990 IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303.
5. Löwik CWGM, van der Pluijm G, Bloys H, Hoekman K, Bijvoet OLM, Aarden LA, Papapoulos SE 1989 Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role in osteoclastogenesis. Biochem Biophys Res Commun 162:1546-1552.
6. Ohsaki Y, Takahashi S, Scarcez T, Demulder A, Nishihara T, Williams R, Roodman GD 1992 Evidence for an autocrine/ paracrine role for IL-6 in bone resorption by giant cell tumors of bone. Endocrinology 131:2229-2234.
7. Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD 1990 IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 144:4226-4230.
8. Al-Humidan A, Ralston SH, Hughes DE, Chapman K, Aarden L, Russell RGG, Gowen M 1991 Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae. J Bone Miner Res 6:3-8.
9. Pottratz S, Bellido T, Mocharla H, Crabb DS, Manolagas SC 1994 17β-estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest 93:944-950.
10. Ray A, Prefontaine KE, Ray P 1994 Down-modulation of interleukin-6 gene expression by 17β-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J Biol Chem 269:12940-12946.
11. Passeri G, Girasole G, Jilka RL, Manolagas SC 1993 Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal. Endocrinology 133:822-828.
12. Yoneda T, Nakai M, Moriyama K, Scott L, Ida N, Kunimoto T, Mundy GR 1993 Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamos carcinoma. Cancer Res 53:737-740.
13. Black K, Garrett IR, Mundy GR 1991 Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology 128:2657-2659.
14. de la Mata J, Uy HL, Guise TA, Story B, Boyce BF, Mundy GR, Roodman GD 1995 IL-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest 95:2846-2852.
15. Weissglas M, Shamhart D, Löwik C, Papapoulos S, Vos P, Kurth KH 1995 Hypercalcemia and cosecretion of interleukin 6 and parathyroid hormone related peptide by a human renal cell carcinoma implanted into nude mice. J Urol 153:854-857.
16. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T 1988 Autocrine generation and requirement of BSF- 2/IL-6 for human multiple myelomas. Nature 332:83-85.
17. Klein B, Zhang X-G, Jourdan M, Content J, Houssiau F, Aarden L, Piechaczyk M, Bataille R 1989 Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73:517-526.
18. Pelliniemi IT, Irjala K, Mattila K, Pulkki K, Rajamaki A, Tienhaara A, Laakso M, Lahtinen R 1995 Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Blood 85:765-771.
19. Rifkin BR, Heigl L 1979 The occurrence of mononuclear cells at sites of osteoclastic bone resorption in experimental periodontitis. J Periodontol 50:636-640.
20. Rutherford B, Trummel CL 1983 Monocyte-mediated bone resorption involves release of nondialyzable substances in addition to prostaglandin. J Reticuloendothel Soc 33:175-184.
21. Kishimoto T 1989 The biology of interleukin-6. Blood 74:1-10.
22. Aarden LA, DeGroot ER, Shaap OL, Lansdorp PM 1987 Production of hybridoma growth factor by human monocytes. Eur J Immunol 17:1411-1416.
23. Bornefalk E, Lindh E, Ljunghall S, Johansson AG, Ljunggren Ö 1995 Interleukin-6 secretion from mononucleated blood cells is affected by serum calcium. Calcif Tissue 56:Abstract 316.
24. Nussbaum SR, Zahradnik RJ, Lavigne JR, Brennan GL, Nozawa-Ung K, Kim LY, Keutman HT, Wang CA, Potts Jr JT, Segre GV 1987 Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 33:1364-1367.
25. Ljunghall S, Larsson K, Lindh E, Lindqvist U, Rastad J, Åkerström G, Wide L 1991 Disturbance of basal and stimulated serum levels of intact parathyroid hormone in primary hyperparathyroidism. Surgery 110:47-53.
26. Yin ET, Galanos C, Kinsky S, Bradshaw RA, Wessler S, Lud eritz O, Sarmiento ME 1972 Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria. Biochem Biophys Acta 261:284-289.
27. Logue FC, Fraser WD, O'Reilly D St J, Beastall GH 1989 The circadian rhythm of intact parathyroid hormone (1-84) and nephrogenous cyclic adenosine monophosphate in normal men. J Endocrinol 121:R1-R3.
28. Fraser WD, Logue FC, Christie JP, Cameron DA, O'Reilly D St J, Beastall GH 1994 Alteration of the circadian rhythm of intact parathyroid hormone following a 96-hour fast. Clin Endocrinol 40:523-528.
29. Calvo MS, Eastell R, Offord KP, Bergstralh EJ, Burritt MF 1991 Circadian variation in ionized calcium and intact parathyroid hormone: Evidence for sex differences in calcium homeostasis. J Clin Endocrinol Metab 72:69-76.
30. Herfarth K, Schmidt-Gayk H, Graf S, Maier A 1992 Circadian rhythm and pulsatility of parathyroid hormone in man. Clin Endocrinol 37:511-519.
31. Pacifici R, Rifas L, Teitelbaum S, Slatopolsky E, McCracken R, Bergfeld M, Lee W, Avioli LV, Peck WA 1987 Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis. Proc Natl Acad Sci USA 84:4616-4620.
32. Bataille R, Jourdan M, Zhang XG, Klein B 1989 Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias. J Clin Invest 84:2008-2011.
33. Bataille R, Barlogie B, Yang Lu Z, Rossi J-F, Lavabre Bertrand T, Beck T, Widjenes J, Brochier J, Klein B 1995 Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood 86:685-691.
34. Vanderschueren B, Dumon JC, Oleffe V, Heymans C, Gérain J, Body JJ 1994 Circulating concentrations of interleukin-6 in cancer patients and their pathogenic role in tumor-induced hypercalcemia. Cancer Immunol Immunother 39:286-290.
35. 2+-sensing receptor from bovine parathyroid. Nature 366:575-580.
36. Lundgren S, Hjälm G, Hellman P, Ek B, Juhlin C, Rastad J, Klareskog L, Åkerström G, Rask L 1994 A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein super- family. Exp Cell Res 212:344-350.