Regulation of murine fetal-placental calcium metabolism by the calcium- sensing receptor

Journal of Clinical Investigation

Volumn 101, Issue 12, 1998, Pages 2812-2820

  Kovacs, Christopher S ^a,e   Ho Pao, Chrystal L ^b,f   Hunzelman, Joy L ^a   Lanske, Beate ^a,g   Fox, John ^d   Seidman, J G ^b,c   Seidman, Christine E ^c   Kronenberg, Henry M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NPS Pharmaceutical Inc   (United States)

^e MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

1,25 dihydroxyvitamin D; Calcitonin; Parathyroid glands; Placenta; PTH

Indexed keywords

CALCITRIOL; CALCIUM SENSING RECEPTOR; CELL RECEPTOR; CELL SURFACE RECEPTOR; DEOXYPYRIDINOLINE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; UNCLASSIFIED DRUG;

AMNION FLUID; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM METABOLISM; CALCIUM TRANSPORT; FETUS; FETUS CIRCULATION; GENE DISRUPTION; HYPERCALCEMIA; HYPERTHYROIDISM; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; REGULATORY MECHANISM; VITAMIN BLOOD LEVEL;

EID: 0032525850     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2940     Document Type: Article

References (33)

1. Brown, E.M., M. Pollak, C.E. Seidman, J.G. Seidman, Y.H. Chou, D. Riccardi, and S.C. Hebert. 1995. Calcium-ion-sensing cell-surface receptors. N. Engl. J. Med. 333:234-240.
2. Chattopadhyay, N., A. Mithal, and E.M. Brown. 1996. The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocrine Rev. 17:289-307.
3. 2+-sensing receptor from bovine parathyroid. Nature. 366:575-580.
4. Riccardi, D., J. Park, W.S. Lee, G. Gamba, E.M. Brown, and S.C. Hebert. 1995. Cloning and functional expression of a rat kidney extracellular calcium/ polyvalent cation-sensing receptor. Proc. Natl. Acad. Sci. USA. 92:131-135.
5. Garrett, J.E., H. Tamir, O. Kifor, R.T. Simin, K.V. Rogers, A. Mithal, R.F. Gagel, and E.M. Brown. 1995. Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology. 136:5202-5211.
6. Ruat, M., M.E. Molliver, A.M. Snowman, and S.H. Snyder. 1995. Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc. Natl. Acad. Sci. USA. 92:3161-3165.
7. Potts, J.T., Jr., F.R. Bringhurst, T. Gardella, S. Nussbaum, G. Segre, and H.M. Kronenberg. 1995. Parathyroid hormone: physiology, chemistry, biosynthesis, secretion, metabolism, and mode of action. In Endocrinology. L.J. De-Groot, editor. W.B Saunders, Philadelphia. 920-966.
8. 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell. 75:1297-1303.
9. 2+-sensing receptor gene mutation. Nat. Genet. 8: 303-307.
10. Pearce, S.H., C. Williamson, O. Kifor, M. Bai, M.G. Coulthard, M. Davies, N. Lewis-Barned, D. McCredie, H. Powell, P. Kendall-Taylor, E.M. Brown, and R. V. Thakker. 1996. A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. N. Engl. J. Med. 335:1115-1122.
11. Kovacs, C.S., and H.M. Kronenberg. 1997. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium and lactation. Endocrine Rev. 18:832-872.
12. Hosking, D.J. 1996. Calcium homeostasis in pregnancy. Clin. Endocrinol. (Oxf.). 45:1-6.
13. Care, A.D., I.W. Caple, S.K. Abbas, and D.W. Pickard. 1986. The effect of fetal thyroparathyroidectomy on the transport of calcium across the ovine placenta to the fetus. Placenta. 7:417-424.
14. Weatherley, A.J., R. Ross, D.W. Pickard, and A.D. Care. 1983. The transfer of calcium during perfusion of the placenta and intact and thyroparathyroidectomized sheep. Placenta. 4:271-277.
15. Abbas, S.K., D.W. Pickard, C.P. Rodda, J.A. Heath, R.G. Hammonds, W.I. Wood, I.W. Caple, T.J. Martin, and A.D. Care. 1989. Stimulation of ovine placental calcium transport by purified natural and recombinant parathyroid hormone-related protein (PTHrP) preparations. Q. J. Exp. Physiol. 74:549-552.
16. Care, A.D., S.K. Abbas, D.W. Pickard, M. Barri, M. Drinkhill, J.B. Findlay, I.R. White, and I.W. Caple. 1990. Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. Exp. Physiol. 75:605-608.
17. Kovacs, C.S., B. Lanske, J.L. Hunzelman, J. Guo, A.C. Karaplis, and H.M. Kronenberg. 1996. Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc. Natl. Acad. Sci. USA. 93:15233-15238.
18. Dvir, R., A. Golander, N. Jaccard, G. Yedwab, I. Otremski, Z. Spirer, and Y. Weisman. 1995. Amniotic fluid and plasma levels of parathyroid hormone-related protein and hormonal modulation of its secretion by amniotic fluid cells. Eur. J. Endocrinol. 133:277-282.
19. Thiébaud, D., S. Janisch, H. Koelbl, E. Hanzal, A.F. Jacquet, S. Leodolter, P. Burckhardt, and M. Pecherstorfer. 1993. Direct evidence of a parathyroid related protein gradient between the mother and the newborn in humans. Bone Miner. 23:213-221.
20. Khosla, S., K.L. Johansen, S.J. Ory, P.C. O'Brien, and P.C. Kao. 1990. Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo. Clin. Proc. 65:1408-1414.
21. Chattopadhyay, N., N. Baum, M. Bai, D. Riccardi, S.C. Hebert, E.W. Harris, and E.M. Brown. 1996. Ontogeny of the extracellular calcium-sensing receptor in rat kidney. Am. J. Physiol. 271:F736-F743.
22. Ho, C., D.A. Conner, M.R. Pollak, D.J. Ladd, O. Kifor, H.B. Warren, E.M. Brown, J.G. Seidman, and C.E. Seidman. 1995. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat. Genet. 11:389-394.
23. Karaplis, A.C., A. Luz, J. Glowacki, R.T. Bronson, V.L. Tybulewicz, H.M. Kronenberg, and R.C. Mulligan. 1994. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes & Dev. 8:277-289.
24. Lanske, B., A.C. Karaplis, K. Lee, A. Luz, A. Vortkamp, A. Pirro, M. Karperien, L. Defize, C. Ho, A.B. Abou-Samra, H. Jüppner, G.V. Segre, and H.M. Kronenberg. 1996. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 273:663-666.
25. Lavigne, J.R., R.J. Zahradnik, R.L. Conklin, L.D. Lambert, M.A. Logan, A. Parihar, and J. Fox. 1997. Development and use of a new, highly-sensitive immunoradiometric assay (IRMA) specific for rat calcitonin (abstr.). In Proceedings of the 79th Annual Meeting of the Endocrine Society. June 11-14, 1997, Minneapolis, Minnesota. Endocrine Society, Bethesda, MD. 243.
26. Wallach, S., and R.L. Verch. 1984. Placental transport of chromium. J. Am. Coll. Nutr. 3:69-74.
27. Symonds, H.W., B.F. Sansom, and A.R. Twardock. 1972. The measurement of the transfer of calcium and phosphorus from foetus to dam in the sheep using a whole body counter. Res. Vet. Sci. 13:272-275.
28. Ramberg, C.F., Jr., M. Delivoria-Papadopoulos, E.D. Crandall, and D.S. Kronfeld. 1973. Kinetic analysis of calcium transport across the placenta. J. Appl. Physiol. 35:682-688.
29. Eyre, D.R. 1996. Biochemical basis of collagen metabolites as bone turnover markers. In Principles of Bone Biology. J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. Academic Press, San Diego, 143-153.
30. Brace, R.A. 1994. Amniotic fluid dynamics. In Maternal-Fetal Medicine: Principles and Practice. R.K. Creasy and R. Resnik, editors. W.B. Saunders, Philadelphia. 106-114.
31. Brommage, R., and H.F. DeLuca. 1984. Placental transport of calcium and phosphorus is not regulated by vitamin D. Am. J. Physiol. 246:F526-F529.
32. Hellman, P., P. Ridefelt, C. Juhlin, G. Akerstrom, J. Rastad, and E. Gylfe. 1992. Parathyroid-like regulation of parathyroid-hormone-related protein release and cytoplasmic calcium in cytotrophoblast cells of human placenta. Arch. Biochem. Biophys. 293:174-180.
33. Tucci, J., A. Russell, P.V. Senior, R. Fernley, T. Ferraro, and F. Beck. 1996. The expression of parathyroid hormone and parathyroid hormone-related protein in developing rat parathyroid glands. J. Mol. Endocrinol. 17:149-157.