A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 1, 1999, Pages 245-250

  Ishioka, Norio ^a   Bukoski, Richard D ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; ANANDAMIDE; CANNABINOID RECEPTOR AGONIST; IBERIOTOXIN; INDOMETACIN; MICONAZOLE; POTASSIUM CHANNEL; RIMONABANT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ARACHIDONIC ACID METABOLISM; ARTICLE; CALCIUM TRANSPORT; DRUG EFFECT; HYPERPOLARIZATION; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ANIMALS; ARACHIDONIC ACIDS; CALCIUM SIGNALING; CANNABINOIDS; ISOMETRIC CONTRACTION; MALE; MESENTERIC ARTERIES; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NEURONS, AFFERENT; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; PINACIDIL; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNEL BLOCKERS; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; VASOCONSTRICTOR AGENTS;

EID: 0032892526     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. 2+. Am J Physiol 269:H230-H238.
2. Bisogno T, Maurelli S, Melck D, De Petrocellis L and DiMarzo V (1997) Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide by leukocytes. J Biol Chem 272:3315-3323.
3. 2+-sensing receptor from bovine parathyroid. Nature (London)366:575-580.
4. 2+ induced relaxation of isolated arteries. Hypertension 30:1431-1439.
5. Crawley JN, Corwin RL, Robinson JK, Felder CC, Devane WA and Axelrod J (1993) Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents. Pharmacol Biochem Behav 46:967-972.
6. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (Wash DC) 258:1946-1949.
7. Devane WA and Axelrod J (1994) Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. Proc Natl Acad Sci USA 91:6698-6701.
8. Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC and Piomelli D (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature (London)372:686-691.
9. Deutsch DG, Gologorsky MS, Schmid PC, Krebsbach RJ, Schmid HH, Das SK, Arreaza G, Thorup C, Stefano G and Moore LC (1997) Production and physiologic actions of anandamide in the vasculature of the kidney. J Clin Invest 100:1538-1546.
10. 9-THC dilation of cerebral arterioles is blocked by indomethacin. Am J Physiol 269:H1859-H1864.
11. Felder CC, Briley EM, Axelrod J, Simpson JT, Mackie K and Devane WA (1993) Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 90:7656-7660.
12. Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lai Y, Ma AL and Mitchell RL (1995) Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48:443-450.
13. Felder CC, Nielson A, Briley EM, Palkovits M, Priller J, Axelrod J, Nguyen DN, Richardson JM, Riggin RM, Koppel GA, Paul SM and Becker GW (1996) Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. FEBS Lett 393:231-235.
14. Fride E and Mechoulam R (1993) Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. Eur J Pharmacol 231:313-314.
15. Galvez A, Gimenez-Gallego G, Reuben JP, Roy-Contancin L, Feigenbaum P, Kaczorowski GJ and Garcia ML (1990) Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem 265:11083-11090.
16. Gerard CM, Mollereau C, Vassart G and Parmentier M (1991) Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J 279: 129-134.
17. Lake KD, Maratin BR, Kunos G and Varga K (1997) Cardiovascular effects of anandamide in anesthetized and conscious normotensive and hypertensive rats. Hypertension 29:1204-1210.
18. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (London) 346:561-563.
19. + channel openers. J Vasc Res 30:2-12.
20. Munro S, Thomas KL and Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (London)365:61-65.
21. 2+-induced relaxation of isolated mesenteric resistance arteries. Am J Physiol 274:H1655-H1661.
22. 2+ receptor. Hypertension 32:603.
23. + channels mediate an endothelium-dependent hyperpolarization in rabbit mesenteric arteries. J Physiol (London) 489:723-734.
24. Pertwee RG, Fernando SR, Griffin G, Abadji V and Makriyannis A (1995) Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations. Eur J Pharmacol 272:73-78.
25. Plane F, Holland M, Waldron GJ, Garland CJ and Boyle JP (1997) Evidence that anandamide and EDHF act via different mechanisms in rat mesenteric arteries. Br J Pharmacol 121:1509-1511.
26. 1 cannabinoid receptor. Am J Physiol 274:H375-H381.
27. + currents in smooth muscle cells from rat resistance-sized cerebral arteries. Am J Physiol 265:C1363-C1370.
28. Randall MD, Alexander SPH, Bennett T, Boyd EA, Fry JR, Gardiner SH, Kemp PA, McCulloch AI and Kendall DA (1996) An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem Biophys Res Commun 229:114-120.
29. Riccardi D, Park J, Li WS, Gamba G, Brown EM and Hebert SC (1995) Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 92:131-135.
30. Rinaldi-Carmona M, Barth F, Heauleme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Neliat G, Caput D, Ferrara P, Breliere JC and Le Fur G (1994) SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240-244.
31. Ruat M, Molliver ME, Snowman AM and Snyder SM (1995) Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc Natl Acad Sci USA 92:3161-3165.
32. Schmid PC, Zuzarte-Augustin ML and Schmid HO (1985) Properties of rat liver N-acylethanolamine amidohydrolase. J Biol Chem 260:14145-14149.
33. Showalter VM, Compton DR, Martin BR and Abood ME (1996) Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278:989-999.
34. Smith PB, Compton DR, Welch SP, Razdan RK, Mechoulam R and Martin BR (1994) The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice. J Pharmacol Exp Ther 270:219-227.
35. Sugiura T, Kondo S, Sukagawa A, Tonegawa T, Nakane S, Yamashita A, Ishima Y and Waku K (1996) Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine. Eur J Biochem 240:53-62.
36. Varga K, Lake KD, Huangfu D, Guyenet PG and Kunos G (1996) Mechanism of the hypotensive action of anandamide in anesthetized rats. Hypertension 28:682-686.
37. Wagner JA, Varga K, Ellis EF, Rzigalinski BA, Martin BR and Kunos G (1997) Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. Nature (London) 390:518-521.
38. White R and Hiley CR (1997) A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. Br J Pharmacol 122: 1573-1584.