Pyrimethamine-resistant Plasmodium falciparum parasites among Tanzanian children: A facility-based study using the polymerase chain reaction

American Journal of Tropical Medicine and Hygiene

Volumn 57, Issue 3, 1997, Pages 342-347

  Edoh, Dominic ^a   Mshinda, Hassan ^a   Jenkins, Jennifer ^b   Burger, Max ^c  

^a IFAKARA HEALTH INSTITUTE   (Tanzania)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FANSIDAR; PYRIMETHAMINE; SULFADOXINE;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; INFANT; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; TANZANIA;

PLASMODIUM FALCIPARUM;

EID: 0030954831     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1997.57.342     Document Type: Article

References (27)

1. Black RH, 1986. Bruce-Chwatt LJ, ed. Chemotherapy of Malaria. Geneva: World Health Organization.
2. Peters W, 1987. Chemotherapy and Drug Resistance in Malaria. New York: Academic Press.
3. World Health Organization. 1986. WHO expert committee on malaria. World Health Organ Tech Rep Ser 735: 57-59.
4. Bjorkman A, Philips-Howard PA, 1990. The epidemiology of drug resistant malaria. Trans R Soc Top Med Hyg 84: 177-180.
5. Onori E, Payne D, Grab B, Horst HI, Almeido Franco J, Joia H, 1982. Incipient resistance of Plasmodium falciparum to chloroquine among a semi-immune population of the United Republic of Tanzania. I. Results of in vivo and in vitro studies and of an ophthalmological survey. Bull World Health Organ 60: 77-82.
6. Kihamia CM, Gill HS, 1982. Chloroquine-resistant falciparum malaria in semi-immune native African Tanzanians. Lancet ii: 43.
7. Wellems TE, 1991. Molecular genetics of drug resistance in Plasmodium falciparum malaria. Parasitol Today 7: 110-112.
8. Chulay JD, Watkins WM, Sixsmith DG, 1984. Synergistic antimalarial activity of pyrimethamine and sulfadoxine against Plasmodium falciparum in vitro. Am J Trop Med Hyg 33: 325-330.
9. Onori E, 1984. Incipient resistance of Plasmodium falciparum to pyrimethamine among semi-immunes in Tanzania. Bull World Health Organ 84: 55-56.
10. Clyde DF, 1967. Malaria in Tanzania. London: University Press.
11. Peterson DS, Milhouse WK, Wellems TE, 1990. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci USA 87: 3018-3022.
12. Foote SJ, Galatis D, Cowman AF, 1990. Amino acids in the dihydrofolate-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance. Proc Natl Acad Sci 87: 3014-3017.
13. Peterson DS, Santi SM, Povoa M, Calvosa VS, De Bosario VE, Wellems T, 1991. High incidence of Asn-108 mutation in dihydrofolate reductase gene as the basis for pyrimethamine resistant falciparum malaria in the Brazilian Amazon. Am J Trop Med Hyg 45: 492-497.
14. Chen GX, Mueller C, Wendlinger M, Zolg JW, 1987. Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum. Mol Pharmcacol 31: 430-437.
15. Zolg JW, Plitt JR, Chen GX, Palmer S, 1989. Point mutations in the dihydrofolate reductase-thymidylate synthetase gene as the molecular basis for pyrimethamine resistance in in Plasmodium falciparum. Mol Biochem Parasitol 36: 253-262.
16. Kwok S, Kellogg DE, McKinney N, Spasic D, Goda L, Levenson C, Sninksky JJ, 1990. Effects of primer-template mismatches on the polymerase chain reaction: human immunodeficiency virus type 1 model studies. Nucleic Acids Res 18: 999-1005.
17. Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KM, 1993. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of a mixed infection. Mol Biochem Parasitol 58: 283-292.
18. Smith T, Charlwood JD, Kihonda J, Mwankusye S, Billingsley P, Meuwissen J, Lyimo E, Takken W, Teuscher T, Tanner M, 1993. Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Trop 54: 55-72.
19. Shute GT, 1988. The microscopic diagnosis of malaria. Wernsdorfer, WN, McGregor, I, eds. Malaria. Volume I. Edinburgh: Churchill Livingstone, 781-814.
20. Sambrook J, Fritsch GF, Maniatis T, eds. 1989. Molecular Cloning. A Laboratory Manual. Second edition. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
21. Smith T, Schellenberg A, Hayes R, 1994. Attributable fraction estimates and case definitions for malaria in endemic areas. Stat Med 13: 2345-2358.
22. Zolg JW, Chen GX, Plitt JR, 1990. Detection of pyrimethamine resistance in Plasmodium falciparum by mutation specific-polymerase chain reaction. Mol Biochem Parasitol 39: 257-265.
23. Bruce-Chwatt LJ, Black RH, Canfield CJ, Clyde DF, Peters W, Wernsdorfer WH, 1986. Chemotherapy in Malaria. Geneva: World Health Organization.
24. Tirasophon W, Rajkulchai P, Ponglikitmongkol M, Wilairat P, Boonsaeng V, Panyim S, 1994. A highly sensitive rapid, and simple polymerase chain reaction-based method to detect human malaria (Plasmodium falciparum and Plasmodium vivax) in blood samples. Am J Trop Med Hyg 51: 308-313.
25. Walliker D, Quakyi JA, Wellems TE, McCutchan TF Szarfman A, London WT, Corcoon LM, Burkot JR, Carter R, 1987. Genetic analysis of the human malaria parasite Plasmodium falciparum. Science 236: 1661-1666.
26. Brooks DR, Wang P, Read M, Watkins MW, Sims PFG Hyde JE, 1994. Sequence, variation of the hydroxymethyldihydropterin pyrophosphokinase dihydrosynthetase gene in lines of the human malaria parasites. Eur J Biochem 224: 397-405.
27. Wang P, Brooks DR, Sims PFG, Hyde JE, 1995. A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthetase gene of Plasmodium falciparum. Mol Biochem Parasitol 71: 115-125.