Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 20, 1997, Pages 10931-10936

  Fidock, David A ^a,b   Wellems, Thomas E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE; DIHYDROFOLATE REDUCTASE; PROGUANIL; PYRIMETHAMINE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; MALARIA; MALIGNANT TRANSFORMATION; MYCOBACTERIUM AVIUM; NONHUMAN; NUCLEOTIDE METABOLISM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STEM CELL;

ANIMALS; ANTIMALARIALS; CHLOROGUANIDE; DNA REPLICATION; DNA, COMPLEMENTARY; DRUG RESISTANCE; GENETIC COMPLEMENTATION TEST; HUMANS; METHOTREXATE; PLASMODIUM FALCIPARUM; TETRAHYDROFOLATE DEHYDROGENASE; TRANSFORMATION, GENETIC; TRIAZINES;

MYCOBACTERIUM; MYCOBACTERIUM AVIUM; PLASMODIUM FALCIPARUM;

EID: 0030885188     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.20.10931     Document Type: Article

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