Molecular epidemiology of Plasmodium falciparum antifolate resistance in Vietnam: Genotyping for resistance variants of dihydropteroate synthase and dihydrofolate reductase

International Journal of Antimicrobial Agents

Volumn 12, Issue 3, 1999, Pages 203-211

  Masimirembwa, C M ^a   Phuong dung, N ^b   Phuc, B Q ^b   Duc Dao, L ^b   Sy, N D ^b   Skold O ^a   Swedberg, G ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Inst Malariology   (Viet Nam)

Author keywords

Antifolate resistance mutations; Dihydrofolate reductase; Dihydropteroate synthase; Plasmodium falciparum; Vietnam

Indexed keywords

ARTEMISININ; CHLOROQUINE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; FOLIC ACID ANTAGONIST; PROGUANIL; PYRIMETHAMINE; SULFADOXINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS RESISTANCE; GENE SEQUENCE; HUMAN; MALARIA FALCIPARUM; MOLECULAR CLONING; MUTATION; ORAL DRUG ADMINISTRATION; PARASITEMIA; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIET NAM;

ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DIHYDROPTEROATE SYNTHASE; DNA PRIMERS; EPIDEMIOLOGY, MOLECULAR; FOLIC ACID ANTAGONISTS; GENOTYPE; HUMANS; MALARIA, FALCIPARUM; MUTATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; TETRAHYDROFOLATE DEHYDROGENASE; VIETNAM;

EID: 0032769234     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(99)00061-8     Document Type: Article

References (29)

1. Advances in Malaria Chemotherapy. WHO Techincal Report Series 711 1984. WHO, Geneva.
2. Plowe CV, Wellems TE. Molecular approaches to the spreading problem of drug resistant malaria. Adv Exp Med Biol 1995;390:197-209.
3. Bloland PB, Lackritz EM, Kazembe PN, Were JBO, Steketee R, Campbell CC. Beyond chloroquine: Implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa. J Infect Dis 1993;167:932-7.
4. Fairlamb AH. Novel biochemical pathways in parasitic protozoa. Parasitology 1989;99:Suppl: S93-112.
5. Peters W. The prevention of antimalarial drug resistance. Pharmacol Ther 1990;47:499-508.
6. Triglia T, Cowman AF. Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Proc Natl Acad Sci USA 1994;91:7149-53.
7. Brooks DR, Wang P, Read M, Watkins WM, Sims PFG, Hyde JE. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulphadoxine. Eur J Biochem 1994;224:397-405.
8. Bzik DJ, Li WB, Horii T, Inselburg J. Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Proc Natl Acad Sci USA 1987;84:8360-4.
9. Cowman AF, Morry MJ, Biggs BA, Cross GAM, Foote SJ. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci USA 1988;85:9109-13.
10. Peterson DS, Walliker D, Wellems TE. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA 1988;85:9114-8.
11. Peterson DS, Milhous WK, Wellems TE. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci USA 1990;87:3018-22.
12. Wang P, Brooks DR, Sims PFG, Hyde JE. A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthetase gene of Plasmodium falciparum. Mol Biochem Parasitol 1995;71:115-25.
13. Gyang FN, Peterson DS, Wellems TE. Plasmodium falciparum: rapid detection of dihydrofolate reductase mutations that confer resistance to cycloguanil and pyrimethamine. Exp Parasitol 1992;74:470-2.
14. Zolg JW, Chen GX, Plitt JR. Detection of pyrimethamine resistance in Plasmodium falciparum by mutation-specific polymerase chain reaction. Mol Biochem Parasitol 1990;39:257-66.
15. Triglia T, Menting JG, Wilson C, Cowman AF. Mutations in dihydropteroate synthase are responsible for sulfone and sulphonamide resistance in Plasmodium falciparum. Proc Natl Acad Sci USA 1997;94:13944-9.
16. Wang P, Read M, Sims PFG, Hyde JE. Sulphadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol Microbiol 1997;23:979-86.
17. Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 1995;52:565-8.
18. Sirawaraporn W, Sathitkul T, Sirawaraporn R, Yuthavong Y, Santi DV. Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc Natl Acad Sci USA 1997;94:1124-9.
19. Cortese JF, Plowe CV. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Mol Biochem Parasitol 1998;94:205-14.
20. Peterson DS, di Santi SM, Povoa M, Calvosa VS, Do Rosario VE, Wellems TE. Prevalence of the dihydrofolate reductase ASN-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon. Am J Trop Med Hyg 1991;45:492-7.
21. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-termination inhibitors. Proc Natl Acad Sci USA 1977;74:5463-7.
22. Wang P, Lee CS, Bayoumi R, et al. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol 1997;89:161-77.
23. Watkins WM, Sixsmith DG, Chulay JD, Spencer HC. Antagonism of sulphadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid. Mol Biochem Parasitol 1985;14:55-61.
24. Krungkai J, Webster HK, Yuthavong Y. De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparum. Mol Biochem Parasitol 1989;32:25-37.
25. Pang LW, Limsomwong N, Singharaj P, Canfield CJ. Malaria prophylaxis with proguanial and sulfisoxazole in children living in a malaria endemic area. Bull World Health Org 1989;67:51-8.
26. Winstanley P, Watkins W, Muhia D, Szwandts, Amukoye E, Marsh K, Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: Pharmacokinetics and theraputic range. Trans Roy Soc Trop Med Hyg 1997;91:322-327.
27. Shanks GD, Edstein MD, Suriyamongkol V, Timsaad S, Webster HK. Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border. Am J Trop Med Hyg 1992;46:643-8.
28. Helsby NA, Edwards G, Breckenridge AM, Ward SA. The multiple dose pharmacokinetics of proguanil. Br J Clin Pharmacol 1993;35:653-6.
29. Fidock DA, Wellems TE. Transformation with human dihydrofolate reductase renders malaria parasites insenstive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci USA 1997;94:10931-6.