Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 90, Issue 6, 1996, Pages 678-680

  Curtis, J ^a   Duraisingh, M T ^a   Trigg, J K ^a,b   Mbwana, H ^b   Warhurst, D C ^a   Curtis, C F ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b Ubwari Field Station   (Tanzania)

Author keywords

Chlorproguanil; Dapsone; Dihydrofolate reductase gene; Malaria; Plasmodium falciparum; Pyrimethamine; Resistance; Sulfadoxine

Indexed keywords

ANTIMALARIAL AGENT; ASPARAGINE; CHLORPROGUANIL; DAPSONE; DIHYDROFOLATE REDUCTASE; FANSIDAR; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; RESTRICTION ENDONUCLEASE; SERINE;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; TANZANIA;

EID: 0030464590     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(96)90432-0     Document Type: Article

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