-
2
-
-
0028989602
-
Htt is a cytoplasmic protein associated with vesicles in human and rat brain neurons
-
(1995)
Neuron
, vol.14
, pp. 1075-1081
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.3
Schwarz, C.4
Meloni, A.5
Young, C.6
Martin, E.7
Vonsattel, J.-P.8
Carraway, R.9
Reeves, S.10
-
3
-
-
0029152808
-
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8710-8714
-
-
Gutekunst, C.A.1
Levey, A.I.2
Heilman, C.J.3
Whaley, W.L.4
Yi, H.5
Nash, N.R.6
Rees, H.D.7
Madden, J.J.8
Hersch, S.M.9
-
4
-
-
0032587646
-
Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin
-
(1999)
Neurosci
, vol.89
, pp. 1159-1167
-
-
Kim, M.1
Velier, J.2
Chase, K.3
LaForet, G.4
Kalchman, M.5
Hayden, M.6
Won, L.7
Heller, A.8
Aronin, N.9
DiFiglia, M.10
-
6
-
-
0034307476
-
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
-
(2000)
J Neurosci
, vol.20
, pp. 7268-7278
-
-
Kegel, K.B.1
Kim, M.2
Sapp, E.3
McIntyre, C.4
Castano, J.G.5
Aronin, N.6
DiFiglia, M.7
-
8
-
-
0033119123
-
Nuclear and neurophil aggregates in HD. Relationship to neuropathology
-
(1999)
J Neurosci
, vol.19
, pp. 2522-2534
-
-
Gutekunst, C.-A.1
Li, S.-H.2
Yi, H.3
Mulroy, J.4
Kuemmerle, S.5
Jones, R.6
Rye, D.7
Ferrante, R.8
Hersch, S.9
Li, X.-J.10
-
18
-
-
0033614761
-
Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease
-
(1999)
Philos Trans R Soc B Biol Sci
, vol.354
, pp. 981-989
-
-
Cha, J.1
Frey, A.2
Alsdorf, S.3
Kerner, J.4
Kosinski, C.5
Mangiarini, L.6
Penney, J.7
Davies, S.8
Bates, G.9
Young, A.10
-
19
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.1
Turmaine, M.2
Cozens, B.3
DiFiglia, M.4
Sharp, A.5
Ross, C.6
Scherzinger, E.7
Wanker, E.8
Mangiarini, L.9
Bates, G.10
-
20
-
-
0033136692
-
A YAC mouse model for HD with full-length mutant huntingting, cytoplasmic toxicity and selective striatal neurodegeneration
-
(1999)
Neuron
, vol.23
, pp. 181-192
-
-
Hodgson, J.1
Agopyan, N.2
Gutekunst, C.-A.3
Leavitt, B.4
LePiane, F.5
Singaraja, R.6
Smith, D.7
Bissada, N.8
McCutcheon, K.9
Nasir, J.10
-
21
-
-
0032475941
-
Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
-
(1998)
Cell
, vol.95
, pp. 41-53
-
-
Klement, I.1
Skinner, P.2
Kaytor, M.3
Yi, H.4
Hersch, S.5
Clark, H.6
Zoghbi, H.7
Orr, H.8
-
22
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
-
24
-
-
0031469707
-
Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse
-
(1997)
Cell
, vol.91
, pp. 753-763
-
-
Ordway, J.1
Rallaksen-Greene, S.2
Gutekunst, C.-A.3
Bernstein, E.4
Cearley, J.5
Wiener, H.6
Dure, L.7
Lindsey, R.8
Hersch, S.9
Jope, R.10
-
25
-
-
17344367977
-
Behavioral abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA
-
(1998)
Nat Genet
, vol.20
, pp. 198-202
-
-
Reddy, P.1
Williams, M.2
Charles, V.3
Garrett, L.4
Pike-Buchanan, L.5
Whetsell, W.6
Miller, G.7
Tagle, D.8
-
27
-
-
0032919205
-
Formation of polyglutamine inclusions in non-CNS tissue
-
(1999)
Hum Mol Genet
, vol.8
, pp. 813-822
-
-
Sathasivam, K.1
Hobbs, C.2
Turmaine, M.3
Mangiarini, L.4
Mahal, A.5
Bertaux, F.6
Wanker, E.7
Doherty, P.8
Davies, S.9
Bates, G.10
-
28
-
-
7144253143
-
Truncated N-terminal fragments of Htt with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture
-
(1998)
Hum Mol Genet
, vol.7
, pp. 783-790
-
-
Cooper, J.K.1
Schilling, G.2
Peters, M.F.3
Herring, W.J.4
Sharp, A.H.5
Kaminsky, Z.6
Masone, J.7
Khan, F.A.8
Delanoy, M.9
Borchelt, D.R.10
-
29
-
-
0032101287
-
The influence of Htt protein size on nuclear localization and cellular toxicity
-
(1998)
J Cell Biol
, vol.141
, pp. 1097-1105
-
-
Hackam, A.1
Singaraja, R.2
Wellington, C.3
Metzler, M.4
McCutcheon, K.5
Zhang, T.6
Kalchman, M.7
Hayden, M.8
-
32
-
-
0033081766
-
Mutant huntingtin expression in clonal striatal cells: Dissociation of inclusion formation and neuronal survival by caspase inhibition
-
(1999)
J Neurosci
, vol.19
, pp. 964-973
-
-
Kim, M.1
Lee, H.-S.2
LaForet, G.3
McIntyre, C.4
Martin, E.5
Chang, P.6
Kim, T.7
Williams, M.8
Reddy, P.9
Tagle, D.10
-
36
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
(1999)
Hum Mol Genet
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.6
Slunt, H.H.7
Ratovitski, T.8
Cooper, J.K.9
Jenkins, N.A.10
-
41
-
-
0031079648
-
Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
-
(1997)
Chem Biol
, vol.4
, pp. 139-147
-
-
Wolff, B.1
Sanglier, J.-J.2
Wang, Y.3
-
45
-
-
0024988359
-
Activation of programmed cell death by anticancer drugs: Cisplatin as a model system
-
(1990)
Cancer Cells
, vol.2
, pp. 275-280
-
-
Eastman, A.1
-
47
-
-
0025303197
-
Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II
-
(1990)
Mol Pharmacol
, vol.38
, pp. 38-45
-
-
Wassarmann, K.1
Markovits, J.2
Jaxel, C.3
Capranico, G.4
Kohn, K.5
Pommier, Y.6
-
49
-
-
12944263711
-
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6763-6768
-
-
Steffan, J.S.1
Kazantsev, A.2
Spasic-Boskovic, O.3
Greenwald, M.4
Zhu, Y.Z.5
Gohler, H.6
Wanker, E.E.7
Bates, G.P.8
Housman, D.E.9
Thompson, L.M.10
-
50
-
-
0032588968
-
Life without huntingtin: Normal differentiation into functional neurons
-
(1999)
J Neurochem
, vol.72
, pp. 1009-1018
-
-
Metzler, M.1
Chen, N.2
Helgason, C.D.3
Graham, R.K.4
Nichol, K.5
McCutcheon, K.6
Nasir, J.7
Humphries, R.K.8
Raymond, L.A.9
Hayden, M.R.10
-
52
-
-
0033614774
-
Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: Comparison with the distribution of huntingtin in Huntington's disease autopsy brain
-
(1999)
Philos Trans R Soc Lond B Biol Sci
, vol.354
, pp. 1061-1067
-
-
Dorsman, J.1
Smoor, M.2
Maat-Schieman, M.3
Bout, M.4
Siesling, S.5
van Duinen, S.6
Verschuuren, J.7
den Dunne, J.8
Roos, R.9
Ommen, G.10
-
57
-
-
0032555718
-
Roles for proteolysis and trafficking in Notch maturation and signal transduction
-
(1998)
Cell
, vol.94
, pp. 423-426
-
-
Chan, Y.-M.1
January, Y.N.2
-
60
-
-
0034657112
-
Wild-type huntingtin protects from apoptosis upstream of caspase-3
-
(2000)
J Neurosci
, vol.20
, pp. 3705-3713
-
-
Rigamonti, D.1
Bauer, J.H.2
De-Fraja, C.3
Conti, L.4
Sipioni, S.5
Sciorati, C.6
Clementi, E.7
Hackam, A.8
Hayden, M.R.9
Li, Y.10
-
62
-
-
0032851595
-
Increased apoptosis of Huntington's disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
-
(1999)
Nat Med
, vol.10
, pp. 1194-1198
-
-
Sawa, A.1
Wiegand, G.W.2
Cooper, J.3
Margolis, R.L.4
Sharp, A.H.5
Lawler J.F., Jr.6
Greenamyre, J.T.7
Snyder, S.H.8
Ross, C.A.9
-
63
-
-
0034702030
-
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease
-
(2000)
Hum Mol Genet
, vol.9
, pp. 1259-1271
-
-
Luthi-Carter, R.1
Strand, A.2
Peters, N.L.3
Solano, S.M.4
Hollingsworth, Z.R.5
Menon, A.S.6
Frey, A.S.7
Spektor, B.S.8
Penney, E.B.9
Schilling, G.10
-
64
-
-
0001388128
-
Expression of polyglutamine-expanded huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line
-
(1999)
J Biol Chem
, vol.273
, pp. 28873-28877
-
-
Liu, Y.1
-
65
-
-
0033591047
-
Expression of extended polyglutamine sequentially activates initiator and effector caspases
-
(1999)
Biochem Biophys Res Comm
, vol.257
, pp. 724-730
-
-
Miyashita, T.1
Matsui, J.2
Ohtsuka, Y.3
Mami, U.4
Fujishima, S.5
Okamura-Oho, Y.6
Inoue, T.7
Yamada, M.8
-
66
-
-
0033588476
-
Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells
-
(1999)
Neuroreport
, vol.10
, pp. 2435-2438
-
-
Wang, G.1
Mitsui, K.2
Kotliarova, S.3
Yamashita, A.4
Nagao, Y.5
Tokuhiro, S.6
Iwatsubo, T.7
Kanazawa, I.8
Nukina, N.9
-
67
-
-
9344227302
-
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
-
(1996)
Nat Genet
, vol.13
, pp. 442-449
-
-
Goldberg, Y.P.1
Nicholson, D.W.2
Rasper, D.M.3
Kalchman, M.A.4
Koide, H.B.5
Graham, R.K.6
Bromm, M.7
Kazemi-Esfarjani, P.8
Thornberry, N.A.9
Vaillancourt, J.P.10
-
68
-
-
0033587128
-
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
-
(1999)
Nature
, vol.399
, pp. 263-267
-
-
Ona, V.O.1
Li, M.2
Vonsattel, J.P.3
Andrews, L.J.4
Khan, S.Q.5
Chung, W.M.6
Frey, A.S.7
Menon, A.S.8
Li, X.J.9
Stieg, P.E.10
-
69
-
-
0032502715
-
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
-
(1998)
J Biol Chem
, vol.273
, pp. 9158-9167
-
-
Wellington, C.L.1
Ellerby, L.M.2
Hackam, A.S.3
Margolis, R.L.4
Trifiro, M.A.5
Singaraja, R.6
McCutcheon, K.7
Salvesen, G.S.8
Propp, S.S.9
Bromm, M.10
-
71
-
-
0344849472
-
Localization of rabbit huntingtin using a new panel of monoclonal antibodies
-
(1999)
Mol Brain Res
, vol.69
, pp. 10-20
-
-
Wilkinson, F.1
Man, N.2
Manilal, S.3
Thomas, P.4
Neal, J.5
Harper, P.6
Jones, A.7
Morris, G.8
-
72
-
-
4243705861
-
Assay of nuclear protein import in permeabilized cells using flow cytometry
-
Celis J. editors. Cell Biology: A Laboratory Handbook. San Diego: Academic Press
-
(1998)
, pp. 305-313
-
-
Paschal, B.1
|