Localization of rabbit huntingtin using a new panel of monoclonal antibodies

Molecular Brain Research

Volumn 69, Issue 1, 1999, Pages 10-20

  Wilkinson, F L ^a   Thi Man, Nguyen ^a   Manilal, S B ^a   Thomas, P ^b   Neal, J W ^b   Harper, P S ^b   Jones, A L ^b   Morris, G E ^a  

^a GLYNDWR UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Huntington's disease; Langerhans cells and brain; Phage displayed peptide libraries; Trinucleotide repeat

Indexed keywords

HUNTINGTIN; MONOCLONAL ANTIBODY; PEPTIDE LIBRARY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL NUCLEUS INCLUSION BODY; HUNTINGTON CHOREA; IMMUNOBLOTTING; IMMUNOREACTIVITY; KIDNEY PARENCHYMA; LANGERHANS CELL; NONHUMAN; NUCLEOTIDE REPEAT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PURKINJE CELL; RABBIT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BACTERIOPHAGES; BLOTTING, WESTERN; BRAIN CHEMISTRY; CROSS REACTIONS; EPITOPES; GENE LIBRARY; HUNTINGTON DISEASE; LANGERHANS CELLS; MICE; MICE, INBRED BALB C; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PYRAMIDAL CELLS; RABBITS; RECOMBINANT FUSION PROTEINS; TRINUCLEOTIDE REPEATS;

ORYCTOLAGUS CUNICULUS;

EID: 0344849472     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00097-2     Document Type: Article

References (41)

1. Becher M.W., Kotzuk J.A., Sharp J.A., Davies S.W., Bates G.P., Price D.L., Ross C.A. Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length. Neurobiol. Dis. 4:1998;387-397.
2. Bessert D.A., Gutridge K.L., Dunbar J.C., Carlock L.R. The identification of a functional nuclear localization signal in the Huntington's disease protein. Mol. Brain Res. 33:1995;165-173.
3. Boutell J.M., Wood J.D., Harper P.S., Jones A.L. Huntingtin interacts with cystathionine β-synthase. Hum. Mol. Genet. 7:1998;371-378.
4. Burke J.R., Enghild J.J., Martin M.E., Jou X.S., Myers M.A., Roses A.D., Vance J.M., Strittmatter W.J. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat. Med. 2:1996;347-350.
5. De Rooij K.E., Dorsman J.C., Smoor M.A., Den Dunnen J.T., Van Ommen G.J.B. Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation. Hum. Mol. Genet. 5:1996;1093-1099.
6. DiFiglia M., Sapp E., Chase K., Schwarz C., Meloni A., Young C., Martin E., Vonsattel J., Carraway R., Reeves S.A., Boyce F.M., Aronin N. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron. 14:1995;1075-1081.
7. DiFiglia M., Sapp E., Chase K.O., Davies S.W., Bates G.P., Vonsattel J.P., Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science. 277:1997;1990-1993.
8. Ferri G.L., Probert L., Cocchia D., Michetti F., Marangos P.J., Polak J.M. Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system. Nature. 297:1982;409-410.
9. Green H. Human genetic diseases due to codon reiteration: relationship to an evolutionary mechanism. Cell. 74:1993;955-956.
10. Gutekunst C.A., Levey A.I., Heilman C.J., Whaley W.L., Hong Y., Nash N.R., Rees H.D., Madden J.J., Hersch S.M. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc. Natl. Acad. Sci. U.S.A. 92:1995;8710-8714.
11. Hashimoto K. Langerhan's cell granule: an endocytotic organelle. Arch. Dermatol. 104:1971;148.
12. Holmberg M., Duyckaerts C., Durr A., Cancel G., Gourfinkelan I., Damier P., Faucheux B., Trottier Y., Hirsch E.C., Agid Y., Brice A. Spinocerebellar ataxia type 7 (SCA-7): a neurodegenerative disorder with neuronal intranuclear inclusions. Hum. Mol. Genet. 7:1998;913-918.
13. Hoogeveen A.T., Willemsen R., Meyer N., De Rooij K.E., Roos R.A.C., Van Ommen G.B., Galjaard H. Characterisation and localization of the Huntington's disease gene product. Hum. Mol. Genet. 2:1993;2069-2073.
14. Ide K., Nukina N., Masuda N., Goto J., Kanazawa Abnormal gene product identified in Huntington's disease lymphocytes and in brain. Biochem. Biophys. Res. Commun. 209:1995;1119-1125.
15. Jou Y.S., Myers R. Evidence from antibody studies that the CAG repeat in Huntington's disease is expressed in the protein. Hum. Mol. Genet. 4:1995;465-469.
16. Kalchman M.A., Graham R.K., Xia G., Koide H.B., Hodgson J.G., Graham K.C., Goldberg Y.P., Gietz R.D., Pickart C.M., Hayden M.R. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J. Biol. Chem. 271:1996;19385-19394.
17. Lefebvre S., Burglen L., Reboullet S., Clermont S., Burlet P., Viollet L., Benichou B., Craud C., Millasseau P., Zeviani M., LePaslier D., Frezal J., Cohen D., Weissenbach J., Munnich A., Melki J. Identification and characterisation of a spinal muscular atrophy-determining gene. Cell. 80:1995;155-165.
18. Li X.J., Li S.H., Sharp A.H., Nucifora F.C., Schilling G., Lanahan A., Worely P., Snyder S.H., Ross C. A huntingtin-associated protein enriched in brain with implications for pathology. Nature. 378:1995;398-402.
19. Lu Q.L., Partridge T.A. A new blocking method for application of murine monoclonal antibody to mouse tissue sections. J. Histochem. Cytochem. 46:1998;977-983.
20. Murphy G.L., Shepherd R.S., Harris T.J.et al. Ultrastructural documentation of HLA-DR antigen reactivity in normal human acrosyringeal epithelium. J. Invest. Dermatol. 81:1983;181.
21. Nasir J., Floresco S.B., O'Kursky S.B., Diewart V.M., Richman J.M., Zeisler J., Borowski A., Marth J.D., Phillips A.G., Hayden M.R. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioural and morphological changes in heterozygotes. Cell. 81:1995;811-823.
22. thi Man Nguyen, Ellis J.M., Love D.R., Davies K.E., Gatter K.C., Dickson G., Morris G.E. Localization of the DMDL gene-encoded Dystrophin-related Protein using a panel of 19 monoclonal antibodies. Presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain. J. Cell. Biol. 115:1991;1695-1700.
23. Nguyen thi Man, G.E. Morris, 1996, Production of panels of monoclonal antibodies by hybridoma method, in: G.E. Morris (Ed.), Epitope Mapping Protocols: From Methods in Molecular Biology, Vol. 66, Humana Press, pp. 377-389.
24. Paulson H.L., Perez M.K., Trottier Y., Trojanowski J.Q., Subramony S.H., Das S.S., Vig P., Mandel J.L., Fischbeck K.H., Pittman R.N. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron. 19:1997;333-344.
25. A. Pereboev, G.E. Morris, 1996, Reiterative screening of phage-displayed libraries with antibodies, in: G.E. Morris (Ed.), Epitope Mapping Protocols: From Methods in Molecular Biology, Vol. 66, Humana Press, pp. 195-206.
26. Persichetti F., Ambrose C.M., Pei G., McNeil S.M., Srinidhi J., Anderson M.A., Jenkins B., Barnes G.T., Duyao M.P., Kanalay L., Wexler N.S., Myers R.H., Bird E.D., Vonsattel J., MacDonald M.E., Gusella J.F. Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat. Mol. Med. 1:1995;374-383.
27. Perutz M.F., Johnson T., Suzuki M., Finch J.T.Y. Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc. Natl. Acad. Sci. U.S.A. 91:1994;5355-5358.
28. Sapp E., Schwarz C., Chase K., Bhide P.G., Young A.B., Penney J., Vonsattel J.P., Aronin N., DiFiglia M. Huntingtin localization in brains of normal and HD patients. Ann. Neurol. 42:1997;604-612.
29. Scott J.K., Smith G.P. Searching for peptide ligands with an epitope library. Science. 249:1990;386-390.
30. Sharp A.H., Love S.J., Schilling G., Li S.H., Li X.J., Bao J., Wagster M.V., Kotzuk J.A., Steiner J.P., Lao A., Hedreen J., Sisoda S., Snyder S.H., Dawson T.M., Ryugo D.K., Ross C.A. Widespread expression of Huntington's disease gene (IT-15) protein product. Neuron. 14:1995;1065-1074.
31. Skinner P.J., Koshy B.T., Cummings C.J., Klement I.A., Helin K., Servadio A., Zoghbi H.Y., Orr H.T. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature. 389:1997;971-974.
32. Tait D., Riccio M., Sitter A., Scherzinger E., Santi S., Ognibene A., Maraldi N.M., Lehrach H., Wanker E.E. Ataxin-3 is transported into the nucleus and associates with the nuclear matrix. Hum. Mol. Genet. 7:1998;991-997.
33. The Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's Disease chromosomes. Cell. 72:1993;971-983.
34. Trottier Y., Devys D., Imbert G., Saudou F., An I., Lutz Y., Weber C., Agid Y., Hirsch E.T., Mandel J.L. Cellular localization of the Huntington's disease protein and discrimination of the mutated form. Nat. Genet. 10:1995;104-110.
35. Veilier J., Kim M., Schwartz C., Kin T.W., Sapp E., Chase K., Aronin N., DiFiglia M. Wild-type and mutant huntingtin function in vesicle trafficking in the secretory and endocytotic pathways. Exp. Neurol. 152:1998;34-40.
36. Vonsattel J.P., Myers R.H., Stevens T.J., Ferrante R.J., Bird E.D., Richardson E.P. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44:1985;559-577.
37. Wanker E.E., Rovira C., Scherzinger E., Hasenbank R., Walter S., Tait D., Colicelli J., Lehrach H. HIP-1: a huntingtin interacting protein isolated by the yeast two-hybrid system. Hum. Mol. Genet. 6:1997;487-495.
38. Wilkinson F.L., thi Man N., Morris G.E. Monoclonal antibodies from three new regions of huntingtin. Biochem. Soc. Trans. 25:1997;S51.
39. Wood J.D., MacMillan J.C., Harper P.S., Lowenstein P.R., Jones L.A. Partial characterisation of murine huntingtin and apparant variations in the subcellular localization of huntingtin in human, mouse and rat brain. Hum. Mol. Genet. 5:1996;481-487.
40. Xu D.G., Korneleuk R.G., Tamai K., Wigle N., Hakim A., MacKenzie A., Robertson G.S. Distribution of neuronal apoptosis inhibitory protein-like immunoreactivity in the rat central nervous system. J. Comp. Neurol. 382:1997;247-259.
41. Zeitlin S., Liu J.P., Chapman D.L., Papaioannou V.E., Efstratiadis A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat. Genet. 11:1995;155-163.