T cell signal transduction and the role of CD7 in costimulation

Immunologic Research

Volumn 24, Issue 1, 2001, Pages 31-52

  Stillwell, R ^a   Bierer, B E ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CD28; CD3; CD7; Coreceptor; Costimulation; Lymphocyte signal transduction; T cell receptor

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE; RECEPTOR; T LYMPHOCYTE RECEPTOR;

ARTICLE; CELL INTERACTION; CELL MEMBRANE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; LIGAND BINDING; LYMPHOCYTE ACTIVATION; MACROMOLECULE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD28; ANTIGENS, CD7; LYMPHOCYTE ACTIVATION; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0034962295     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:24:1:31     Document Type: Article

References (185)

1. T cell antigen receptor signal transduction
2. Complex complexes: Signaling at the TCR
3. The two-signal model of lymphocyte activation twenty-one years later
4. Cell-cell adhesion mediated by CD8 and MHC class I molecules
5. Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck
6. Costimulatory regulation of T cell function
7. CD28: A signalling perspective
8. Genetic and mutational analysis of the T-cell antigen receptor
9. The T-cell antigen receptor: A multisubunit signaling complex
10. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM)
11. Adaptors and molecular scaffolds in immune cell signaling
12. SH2 and SH3 domains: From structure to function
13. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
14. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
15. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
16. Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase
17. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
18. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation
19. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: The tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
20. A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif
21. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function
22. The role of the Tec protein-tyrosine kinase in T cell signaling
23. Tec kinases: A family with multiple roles in immunity
24. Negative regulation of antigen receptor signaling in lymphocytes
25. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
26. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
27. Recent developments in lymphocyte activation: Linking kinases to downstream signaling events
28. LAT is required for TCR-mediated activation of PLCgamma1 and the ras pathway
29. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
30. Association of Grb2, Gads and phospholipase C-γ1 with phosphorylated LAT tyrosine residues. Effect of tyrosine mutations on T cell antigen receptor-mediated signaling
31. Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation
32. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS
33. Positive and negative signaling pathways
34. Molecular cloning of SLP-76, a 76-kDa tyrosine phospho-protein associated with Grb2 in T cells
35. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production
36. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
37. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor
38. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
39. Mutations at the murine moth-eaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
40. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
41. Negative regulation of T cell activation
42. Organization and regulation of mitogen-activated protein kinase signaling pathways
43. Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes
44. Mitogen-activated protein kinase cascades and regulation of gene expression
45. p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes
46. Protein kinase C alpha activates RAF-1 by direct phosphorylation
47. MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells
48. T cell antigen receptor signal transduction pathways
49. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: The missing link
50. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
51. Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in Jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation
52. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells
53. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
54. JNK is involved in signal integration during costimulation of T lymphocytes
55. Signal transmission between the plasma membrane and nucleus of T lymphocytes
56. Molecular regulation of cytokine gene expression during the immune response
57. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
58. Phosphatidylinositol 3-kinase
59. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
60. Phosphoinositide kinases
61. Phosphoinositide 3-kinases: A conserved family of signal transducers
62. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
63. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways
64. Phosphatidylinositol-3-OH kinase as a direct target of Ras
65. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
66. Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
67. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
68. Vesicular transport. Sticky fingers grab a lipid
69. PH domains - A universal membrane adapter
70. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
71. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
72. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
73. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
74. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
75. p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes
76. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
77. CD28/B7 costimulation: A review
78. The B7 and CD28 receptor families
79. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif
80. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells
81. Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins
82. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: Implications for T-cell costimulation
83. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line
84. Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation
85. Both CD28 ligands CD80 (CD80) and CD86 (CD86) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion
86. Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
87. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
88. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
89. A cell culture model for T lymphocyte clonal anergy
90. T cell clonal anergy
91. Cytokine receptor signal transduction and the control of hematopoietic cell development
92. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells
93. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses
94. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production
95. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines
96. Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway
97. The complexity of the B7-CD28/CTLA-4 costimulatory pathway
98. CD80 and CD86 do not deliver identical costimulatory signals, since CD86 but not CD80 preferentially costimulates the initial production of IL-4
99. CD80 and CD86 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
100. CTLA-4 can function as a negative regulator of T cell activation
101. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
102. Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152)
103. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
104. The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28
105. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
106. CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28
107. CD28/B7 system of T cell costimulation
108. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
109. CD28 can promote T cell survival through a phosphatidylinositol 3-kinase-independent mechanism
110. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
111. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
112. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
113. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
114. The Bcl-2 protein family: Arbiters of cell survival
115. T cell activation determined by T cell receptor number and tunable thresholds
116. Making the T cell receptor go the distance: A topological view of T cell activation
117. Functional rafts in cell membranes
118. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
119. Costimulation: Building an immunological synapse
120. T lymphocyte costimulation mediated by reorganization of membrane microdomains
121. A receptor/cytoskeletal movement triggered by costimulation during T cell activation
122. Heterologous cross-linking of Lyt-2 (CD8) to the alpha beta-T cell receptor is more effective in T cell activation than homologous alpha beta-T cell receptor cross-linking
123. Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation
124. CD4 and CD8: Modulators of T-cell receptor recognition of antigen and of immune responses?
125. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck
126. Immunoregulation through CD8 (Ly-2): State of aggregation with the alpha/beta/CD3 T cell receptor controls interleukin 2-dependent T cell growth
127. Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas ligand expression
128. T cell adhesion, avidity regulation, and signaling: A molecular analysis of CD2
129. The role of CD2 as a regulator of human T-cell cytokine production
130. Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor
131. CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy
132. Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain
133. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
134. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
135. T-cell stimulation: An abundace of B7s
136. LICOS, a primordial costimulatory ligand?
137. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells
138. Differential involvement of a Fas-CPP32-like protease pathway in apoptosis of TCR/CD9-costimulated, naive T cells and TCR-restimulated, activated T cells
139. Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes
140. Triggering of co-mitogenic signals in T cell proliferation by anti-LFA-1 (CD18, CD11a), LFA-3, and CD7 monoclonal antibodies
141. CD7 augments T cell proliferation via the interleukin-2 autocrine pathway
142. Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion
143. Isolation and characterization of a human T lymphocyte-associated glycoprotein (gp40)
144. CD7 is associated with CD3 and CD45 on human T cells
145. Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system
146. SH2 domains recognize specific phosphopeptide sequences
147. CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase
148. Functional association of CD7 with phosphatidylinositol 3-kinase: Interaction via a YEDM motif
149. Antibody ligation of CD7 leads to association with phospboinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes
150. Tyrosine kinase activity associated with the CD7 antigen: Correlation with regulation of T cell integrin function
151. Human lymphocyte antigens: Production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets
152. Human T lymphocyte antigens as defined by monoclonal antibodies
153. Functionally different T lymphocyte subpopulations determined by their sensitivity to complement-dependent cell lysis with the monoclonal antibody 4A
154. Human T cell antigen expression during the early stages of fetal thymic maturation
155. Expression of CD7 on normal human myeloid progenitors
156. Identification of novel B-lineage cells in human fetal bone marrow that coexpress CD7
157. CD7-negative T cells represent a separate differentiation pathway in a subset of post-thymic helper T cells
158. The synergy between naive and memory T cells during activation
159. Ontogeny of T-cell precursors: A model for the initial stages of human T-cell development
160. Identification of pre-T cells in human peripheral blood. Extrathymic differentiation of CD7+CD3- cells into CD3+ gamma/delta+ or alpha/beta+ T cells
161. T cell CD7 mRNA expression is regulated by both transcriptional and post-transcriptional mechanisms
162. Cyclic AMP and calcium regulate at a transcriptional level the expression of the CD7 leukocyte differentiation antigen
163. HLA-DR-positive leucocyte sub-populations in human skin include dendritic cells, macrophages, and CD7-negative T cells
164. Genotypic, phenotypic and functional analysis of CD4+ CD7+ and CD4+CD7- T lymphocyte subsets in Sezary syndrome
165. CD4+ CD7-CD57+ T cells: A new T-lymphocyte subset expanded during human immunodeficiency virus infection
166. Identification of CD7 glycoprotein as an accessory molecule in HIV-1-mediated syncytium formation and cellfree infection
167. Defective expression of T cell-associated glycoprotein in severe combined immunodeficiency
168. Inhibition of lymphocyte proliferation by a monoclonal antibody (RFT2) against CD7
169. The inhibition of T cell proliferative responses by crosslinking CD7 and IgM-Fc receptors
170. Inhibition of alloresponsive naive and memory T cells by CD7 and CD25 anti-bodies and by cyclosporine
171. Direct involvement of CD7 (gp40) in activation of TcR gamma/delta+ T cells
172. Evidence for a structural difference in the CD7 polypeptide on human thymocytes and intraepithelial lymphocytes defined by a new monoclonal antibody, 3D9
173. Cross-linking CD7 on myeloblasts results in granulocyte-macrophage colony-stimulating factor production
174. Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin
175. Expression and function of CD7 molecule on human natural killer cells
176. Characterization of human CD7 transgenic mice
177. Isolation and characterization of mouse CD7 cDNA
178. Targeted gene disruption of murine CD7
179. Immunologic characterization of CD7-deficient mice
180. Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes
181. Interaction between the extracellular domain of CD7 and concanavalin A: A clue to the identity of the ligand for CD7
182. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1
183. Cutting edge: CD7 delivers a pro-apoptotic signal during galectin-I-induced T cell death
184. Identification of CD7 as a cognate of the human K12 (SECTM 1) protein
185. Identification and characterization of K12 (SECTM1), a novel human gene that encodes a golgi-associated protein with transmembrane and secreted isoforms