-
1
-
-
0020643477
-
T cell subsets and the recognition of MHC class
-
Swain S. T cell subsets and the recognition of MHC class. Immunol Rev. 74:1983;129-142.
-
(1983)
Immunol Rev
, vol.74
, pp. 129-142
-
-
Swain, S.1
-
2
-
-
0026600191
-
Identification of a CD4 binding site on the b2 domain of HLA-DR molecules
-
Cammarota G, Schierle A, Takacs B, Doran D, Knorr R, Bannworth W, Guardiola J, Sinigaglia F. Identification of a CD4 binding site on the b2 domain of HLA-DR molecules. Nature. 356:1992;799-801.
-
(1992)
Nature
, vol.356
, pp. 799-801
-
-
Cammarota, G.1
Schierle, A.2
Takacs, B.3
Doran, D.4
Knorr, R.5
Bannworth, W.6
Guardiola, J.7
Sinigaglia, F.8
-
3
-
-
0026563077
-
MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8
-
König R, Huang L-Y, Germain R. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature. 356:1992;796-798.
-
(1992)
Nature
, vol.356
, pp. 796-798
-
-
König, R.1
Huang L-Y2
Germain, R.3
-
4
-
-
0023796326
-
Cell-cell adhesion mediated by CD8 and MHC class I molecules
-
Norment AM, Salter RD, Parham P, Engelhard VH, Littman VH. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature. 336:1988;79-81.
-
(1988)
Nature
, vol.336
, pp. 79-81
-
-
Norment, A.M.1
Salter, R.D.2
Parham, P.3
Engelhard, V.H.4
Littman, V.H.5
-
5
-
-
0025366452
-
A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2
-
Salter RD, Benjamin H, Wesley PK, Buxton SE, Garrett TPJ, Clayberger C, Krensky AM, Norment AM, Littman DR, Parham P. A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2. Nature. 345:1990;41-46.
-
(1990)
Nature
, vol.345
, pp. 41-46
-
-
Salter, R.D.1
Benjamin, H.2
Wesley, P.K.3
Buxton, S.E.4
Garrett, T.P.J.5
Clayberger, C.6
Krensky, A.M.7
Norment, A.M.8
Littman, D.R.9
Parham, P.10
-
7
-
-
0024040125
-
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes
-
Rudd C, Trevillyan J, Dasgupta J, Wong L, Schlossman S. The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc. Natl Acad Sci USA. 85:1988;5190-5194.
-
(1988)
Proc. Natl Acad Sci USA
, vol.85
, pp. 5190-5194
-
-
Rudd, C.1
Trevillyan, J.2
Dasgupta, J.3
Wong, L.4
Schlossman, S.5
-
8
-
-
0026705903
-
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
-
Straus DB, Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 70:1992;585.
-
(1992)
Cell
, vol.70
, pp. 585
-
-
Straus, D.B.1
Weiss, A.2
-
9
-
-
0030250114
-
Complex complexes: Signaling at the TCR
-
of special interest. A recent review of the molecules involved in proximal tyrosine phosphorylation events which accompany TCR triggering.
-
Wange R, Samelson L. Complex complexes: signaling at the TCR. of special interest Immunity. 5:1996;197-205 A recent review of the molecules involved in proximal tyrosine phosphorylation events which accompany TCR triggering.
-
(1996)
Immunity
, vol.5
, pp. 197-205
-
-
Wange, R.1
Samelson, L.2
-
10
-
-
0023504891
-
Coaggregation of the T cell receptor with CD4 and other T cell surface molecules enhances T cell activation
-
Owens T, Fazekas de St Groth B, Miller J. Coaggregation of the T cell receptor with CD4 and other T cell surface molecules enhances T cell activation. Proc Natl Acad Sci USA. 84:1987;9209-9213.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 9209-9213
-
-
Owens, T.1
Fazekas De St Groth, B.2
Miller, J.3
-
11
-
-
0023732011
-
Heterologous cross-linking of Lyt-2 (CD8) to the αβ-T cell rceptor is more effective in T cell activation than homologous αβT cell receptor cross-linking
-
Boyce NW, Jönsson JI, Emmrich F, Eichmann K. Heterologous cross-linking of Lyt-2 (CD8) to the αβ-T cell rceptor is more effective in T cell activation than homologous αβT cell receptor cross-linking. J Immunol. 141:1988;2882-2888.
-
(1988)
J Immunol
, vol.141
, pp. 2882-2888
-
-
Boyce, N.W.1
Jönsson, J.I.2
Emmrich, F.3
Eichmann, K.4
-
12
-
-
0024509925
-
Immunoregulation through CD8 (Ly-2): State of aggregation with the αβ/CD3 T cell receptor controls interleukin 2-dependent T cell growth
-
Jonsson J-I, Boyce NW, Eichmann K. Immunoregulation through CD8 (Ly-2): state of aggregation with the αβ/CD3 T cell receptor controls interleukin 2-dependent T cell growth. Eur J Immunol. 19:1989;253-260.
-
(1989)
Eur J Immunol
, vol.19
, pp. 253-260
-
-
Jonsson J-I1
Boyce, N.W.2
Eichmann, K.3
-
13
-
-
0026681679
-
The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation
-
Janeway CJ. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu Rev Immunol. 10:1992;645-674.
-
(1992)
Annu Rev Immunol
, vol.10
, pp. 645-674
-
-
Janeway, C.J.1
-
14
-
-
0029933309
-
Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
-
of special interest. A comprehensive review of altered peptide ligands, encompassing an overview of current hypotheses of how they exert their effects.
-
Sloan-Lancaster J, Allen P. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. of special interest Annu Rev Immunol. 14:1996;1-27 A comprehensive review of altered peptide ligands, encompassing an overview of current hypotheses of how they exert their effects.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 1-27
-
-
Sloan-Lancaster, J.1
Allen, P.2
-
15
-
-
0030927323
-
Making the T cell receptor go the distance: A topological view of T cell activation
-
of special interest. A refreshing look at T-cell activation which discusses how the physical attributes (size, glycosylation and charge) of various receptors on T cells may affect their interactions with each other and their ligands, and pays particular attention to the different classes of receptors which participate in T-cell activation.
-
Shaw AS, Dustin ML. Making the T cell receptor go the distance: a topological view of T cell activation. of special interest Immunity. 6:1997;361-369 A refreshing look at T-cell activation which discusses how the physical attributes (size, glycosylation and charge) of various receptors on T cells may affect their interactions with each other and their ligands, and pays particular attention to the different classes of receptors which participate in T-cell activation.
-
(1997)
Immunity
, vol.6
, pp. 361-369
-
-
Shaw, A.S.1
Dustin, M.L.2
-
16
-
-
0025224767
-
Crystal structure of an HIV-binding recombinant fragment of human CD4
-
Ryu S-E, Kwong P, Trunch A, Porter T, Arthos J, Rosenberg M, Dai X, Xuong N, Axel R, Sweet R, Hendrickson W. Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature. 348:1990;419-425.
-
(1990)
Nature
, vol.348
, pp. 419-425
-
-
Ryu S-E1
Kwong, P.2
Trunch, A.3
Porter, T.4
Arthos, J.5
Rosenberg, M.6
Dai, X.7
Xuong, N.8
Axel, R.9
Sweet, R.10
Hendrickson, W.11
-
17
-
-
0025198478
-
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
-
Wang J, Yan Y, Garrett T, Liu J, Rodgers D, Garlick R, Tarr G, Husain Y, Reinherz E, Harrison S. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature. 348:1990;411-418.
-
(1990)
Nature
, vol.348
, pp. 411-418
-
-
Wang, J.1
Yan, Y.2
Garrett, T.3
Liu, J.4
Rodgers, D.5
Garlick, R.6
Tarr, G.7
Husain, Y.8
Reinherz, E.9
Harrison, S.10
-
18
-
-
0027219115
-
Crystal structure of domains 3 and 4 of rat CD4: Relation to the NH2-terminal domains
-
Brady RL, Dodson EJ, Dodson GG, Lange G, Davis SJ, Williams AF, Barclay AN. Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains. Science. 260:1993;83-979.
-
(1993)
Science
, vol.260
, pp. 83-979
-
-
Brady, R.L.1
Dodson, E.J.2
Dodson, G.G.3
Lange, G.4
Davis, S.J.5
Williams, A.F.6
Barclay, A.N.7
-
19
-
-
0030911709
-
Dimeric association and segmental variability in the structure of human CD4
-
of special interest. The solution of the crystal structure of the intact CD4 is described, indicating the presence of dimers at high protein concentration.
-
Wu H, Kwong PD, Hendrickson WA. Dimeric association and segmental variability in the structure of human CD4. of special interest Nature. 387:1997;527-530 The solution of the crystal structure of the intact CD4 is described, indicating the presence of dimers at high protein concentration.
-
(1997)
Nature
, vol.387
, pp. 527-530
-
-
Wu, H.1
Kwong, P.D.2
Hendrickson, W.A.3
-
20
-
-
0030926137
-
Ligand-specific oligomerization of T-cell receptor molecules
-
of outstanding interest. This paper describes how TCRs have the potential to oligomerise in a concentration-dependent manner when binding to antigenic MHC/peptide complexes, suggesting that T cell signalling may indeed require TCR multimerisation.
-
Reich Z, Boniface JJ, Lyons DS, Borochov N, Wachtel EJ, Davis MM. Ligand-specific oligomerization of T-cell receptor molecules. of outstanding interest Nature. 387:1997;617-620 This paper describes how TCRs have the potential to oligomerise in a concentration-dependent manner when binding to antigenic MHC/peptide complexes, suggesting that T cell signalling may indeed require TCR multimerisation.
-
(1997)
Nature
, vol.387
, pp. 617-620
-
-
Reich, Z.1
Boniface, J.J.2
Lyons, D.S.3
Borochov, N.4
Wachtel, E.J.5
Davis, M.M.6
-
21
-
-
0030012479
-
The two membrane proximal domains of CD4 interact with the T cell receptor
-
of special interest. Chimaeric mouse CD4 molecules, in which the membrane proximal domains (D3 and D4) were substituted for a variety of other structures, were analysed for their abilities to act as co-receptors. Most interesting were hybrids containing mouse D1 and D2 and human D3 and D4 domains, which not only failed to restore T-cell signalling but acted as a dominant negative interfering with wild-type CD4 function.
-
Vignali DA, Carson RT, Chang B, Mittler BS, Strominger JL. The two membrane proximal domains of CD4 interact with the T cell receptor. of special interest J Exp Med. 183:1996;2097-2107 Chimaeric mouse CD4 molecules, in which the membrane proximal domains (D3 and D4) were substituted for a variety of other structures, were analysed for their abilities to act as co-receptors. Most interesting were hybrids containing mouse D1 and D2 and human D3 and D4 domains, which not only failed to restore T-cell signalling but acted as a dominant negative interfering with wild-type CD4 function.
-
(1996)
J Exp Med
, vol.183
, pp. 2097-2107
-
-
Vignali, D.A.1
Carson, R.T.2
Chang, B.3
Mittler, B.S.4
Strominger, J.L.5
-
22
-
-
0024542793
-
Molecular biology and function of CD4 and CD8
-
Parnes JR. Molecular biology and function of CD4 and CD8. Adv Immunol. 44:1989;265-311.
-
(1989)
Adv Immunol
, vol.44
, pp. 265-311
-
-
Parnes, J.R.1
-
23
-
-
0026600162
-
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
-
Leahy DJ, Axel R, Hendrickson WA. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution. Cell. 68:1992;1145-1162.
-
(1992)
Cell
, vol.68
, pp. 1145-1162
-
-
Leahy, D.J.1
Axel, R.2
Hendrickson, W.A.3
-
24
-
-
0030926140
-
Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2
-
2-microglobulin as sites of interaction. Interestingly, the CD8 homodimer is shown to interact asymmetrically with class I, with only one of the polypeptides making most of the contacts.
-
2-microglobulin as sites of interaction. Interestingly, the CD8 homodimer is shown to interact asymmetrically with class I, with only one of the polypeptides making most of the contacts.
-
(1997)
Nature
, vol.387
, pp. 630-634
-
-
Gao, G.F.1
Tormo, J.2
Gerth, U.C.3
Wyer, J.R.4
McMichael, A.J.5
Stuart, D.I.6
Bell, J.I.7
Jones, E.Y.8
Jakobsen, B.Y.9
-
25
-
-
0021089849
-
The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes
-
Snow PM, Terhorst C. The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes. J Cell Biol. 258:1983;14675-14681.
-
(1983)
J Cell Biol
, vol.258
, pp. 14675-14681
-
-
Snow, P.M.1
Terhorst, C.2
-
26
-
-
0028467946
-
Disruption of T lymphocyte positve and negative selection in mice lacking the CD8β chain
-
Crooks M, Littman D. Disruption of T lymphocyte positve and negative selection in mice lacking the CD8β chain. Immunity. 1:1994;277-286.
-
(1994)
Immunity
, vol.1
, pp. 277-286
-
-
Crooks, M.1
Littman, D.2
-
27
-
-
0028101450
-
+ T cells in CD8β genetargetted mice
-
+ T cells in CD8β genetargetted mice. J Exp Med. 180:1994;959-967.
-
(1994)
J Exp Med
, vol.180
, pp. 959-967
-
-
Fung-Leung W-P1
Kündig, T.2
Ngo, K.3
Panakos, J.4
De Souza-Hitzler, J.5
Wang, E.6
Ohashi, P.7
Mak, T.8
Lau, C.9
-
28
-
-
0028986357
-
CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity
-
Yoko Irie H, Ravichandran KS, Burakoff SJ. CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity. J Exp Med. 181:1995;1267-1273.
-
(1995)
J Exp Med
, vol.181
, pp. 1267-1273
-
-
Yoko Irie, H.1
Ravichandran, K.S.2
Burakoff, S.J.3
-
29
-
-
0029807351
-
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes
-
of outstanding interest. Surface plasmon resonance was used to measure the binding kinetics of CD8αα homodimers and αβ heterodimers to class I MHC. The binding kinetics of the two forms were found to be similar, except that the heterodimer had a slightly faster 'on' rate. The CD8 heterodimer was found to have a significant influence on the interaction between TCR and MHC-peptide molecules, by stabilising the complex formed between them.
-
Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson IA, Teyton L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. of outstanding interest Nature. 384:1996;577-581 Surface plasmon resonance was used to measure the binding kinetics of CD8αα homodimers and αβ heterodimers to class I MHC. The binding kinetics of the two forms were found to be similar, except that the heterodimer had a slightly faster 'on' rate. The CD8 heterodimer was found to have a significant influence on the interaction between TCR and MHC-peptide molecules, by stabilising the complex formed between them.
-
(1996)
Nature
, vol.384
, pp. 577-581
-
-
Garcia, K.C.1
Scott, C.A.2
Brunmark, A.3
Carbone, F.R.4
Peterson, P.A.5
Wilson, I.A.6
Teyton, L.7
-
30
-
-
0030472888
-
CD8β increases CD8 co-receptor function and participation in TCR-ligand binding
-
of outstanding interest. This paper describes a comparison between CD8αα homodimers and αβ heterodimers in restoring the response of a T cell hybridoma. CD8αβ heterodimers were found to be more efficient in promoting the response to antigen and increase T-cell receptor (TCR) - ligand binding more efficiently than CD8αα homodimers.
-
Renard V, Romero P, Vivier E, Malissen B, Luescher I. CD8β increases CD8 co-receptor function and participation in TCR-ligand binding. of outstanding interest J Exp Med. 184:1996;2439-2444 This paper describes a comparison between CD8αα homodimers and αβ heterodimers in restoring the response of a T cell hybridoma. CD8αβ heterodimers were found to be more efficient in promoting the response to antigen and increase T-cell receptor (TCR) - ligand binding more efficiently than CD8αα homodimers.
-
(1996)
J Exp Med
, vol.184
, pp. 2439-2444
-
-
Renard, V.1
Romero, P.2
Vivier, E.3
Malissen, B.4
Luescher, I.5
-
31
-
-
0027410502
-
The roles of CD8 in cytotoxic T lymphocyte function
-
O'Rourke A, Mescher M. The roles of CD8 in cytotoxic T lymphocyte function. Immunol Today. 14:1993;183-188.
-
(1993)
Immunol Today
, vol.14
, pp. 183-188
-
-
O'Rourke, A.1
Mescher, M.2
-
32
-
-
0028797801
-
CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes
-
Luescher IF, Vivier E, Layer A, Mahiou J, Godeau F, Malissen B, Romero P. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature. 373:1995;353-356.
-
(1995)
Nature
, vol.373
, pp. 353-356
-
-
Luescher, I.F.1
Vivier, E.2
Layer, A.3
Mahiou, J.4
Godeau, F.5
Malissen, B.6
Romero, P.7
-
33
-
-
0026008413
-
Cytoskeletal function in CD8- and T cell receptor-mediated interaction of cytotoxic T lymphocytes with class I protein
-
O'Rourke A, Apgar J, Kane K, Martz K, Mescher M. Cytoskeletal function in CD8- and T cell receptor-mediated interaction of cytotoxic T lymphocytes with class I protein. J Exp Med. 173:1991;241-249.
-
(1991)
J Exp Med
, vol.173
, pp. 241-249
-
-
O'Rourke, A.1
Apgar, J.2
Kane, K.3
Martz, K.4
Mescher, M.5
-
34
-
-
0025817991
-
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4
-
Rahemtulla A, Fung-Leung W, Schilham S, Kundig T, Sambhara S, Narendran A, Arabian A, Wakeham A, Paige C, Zinkernagel R, et al. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature. 353:1991;180-184.
-
(1991)
Nature
, vol.353
, pp. 180-184
-
-
Rahemtulla, A.1
Fung-Leung, W.2
Schilham, S.3
Kundig, T.4
Sambhara, S.5
Narendran, A.6
Arabian, A.7
Wakeham, A.8
Paige, C.9
Zinkernagel, R.10
-
35
-
-
0025906133
-
CD8 is needed for development of cytotoxic T cells but not helper T cells
-
Fung-Leung W-P, Schillham M, Rahemtulla A, Kündig T, Vollenweider M, Potter J, van Ewijk M, Mak T. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell. 65:1991;443-449.
-
(1991)
Cell
, vol.65
, pp. 443-449
-
-
Fung-Leung W-P1
Schillham, M.2
Rahemtulla, A.3
Kündig, T.4
Vollenweider, M.5
Potter, J.6
Van Ewijk, M.7
Mak, T.8
-
37
-
-
0027366168
-
+ T lymphocytes
-
+ T lymphocytes. Eur J Immunol. 23:1993;2834-2840.
-
(1993)
Eur J Immunol
, vol.23
, pp. 2834-2840
-
-
Fung-Leung, W.1
Louie, M.2
Limmer, A.3
Ohashi, P.4
Ngo, P.5
Chen, L.6
Kawai, K.7
Lacy, E.8
Loh, D.9
Mak, T.10
-
38
-
-
0030990038
-
CD8 lineage commitment in the absence of CD8
-
wild-type thymocytes. These data show that the CD8 molecule does not provide an obligatory function for differentiation of class I-restricted T cells, but suggests CD8 alters the threshold for positive and negative selection.
-
wild-type thymocytes. These data show that the CD8 molecule does not provide an obligatory function for differentiation of class I-restricted T cells, but suggests CD8 alters the threshold for positive and negative selection.
-
(1997)
Immunity
, vol.6
, pp. 633-642
-
-
Goldrath, A.W.1
Hogquist, K.A.2
Bevan, M.J.3
-
39
-
-
0030916961
-
Peptide-induced positive selection of TCR transgenic thymocytes in a co-receptor-independent manner
-
of outstanding interest. of special interest. A contemporaneous study to [38] reaching similar conclusions for a second class I-restricted transgenic T-cell receptor.
-
of outstanding interest Sebzda E, Choi M, Fung-Leung WP, Mak TW, Ohashi PS. Peptide-induced positive selection of TCR transgenic thymocytes in a co-receptor-independent manner. of special interest Immunity. 6:1997;643-653 A contemporaneous study to [38] reaching similar conclusions for a second class I-restricted transgenic T-cell receptor.
-
(1997)
Immunity
, vol.6
, pp. 643-653
-
-
Sebzda, E.1
Choi, M.2
Fung-Leung, W.P.3
Mak, T.W.4
Ohashi, P.S.5
-
40
-
-
0026572709
-
CD8 expression alters the fine specificity of an alloreactive MHC class I-specific T hybridoma
-
Blok R, Marguiles D, Pease L, Ribaudo R, Schneck J, McCluskey J. CD8 expression alters the fine specificity of an alloreactive MHC class I-specific T hybridoma. Int Immunol. 4:1992;455-466.
-
(1992)
Int Immunol
, vol.4
, pp. 455-466
-
-
Blok, R.1
Marguiles, D.2
Pease, L.3
Ribaudo, R.4
Schneck, J.5
McCluskey, J.6
-
41
-
-
0027265402
-
Role of CD4 and CD8 in T cell activation and differentiation
-
Miceli M, Parnes J. Role of CD4 and CD8 in T cell activation and differentiation. Adv Immunol. 53:1993;59-122.
-
(1993)
Adv Immunol
, vol.53
, pp. 59-122
-
-
Miceli, M.1
Parnes, J.2
-
42
-
-
0028988331
-
T cell receptor antagonists and partial agonists
-
Jameson SC, Bevan MJ. T cell receptor antagonists and partial agonists. Immunity. 2:1995;1-11.
-
(1995)
Immunity
, vol.2
, pp. 1-11
-
-
Jameson, S.C.1
Bevan, M.J.2
-
43
-
-
0029822117
-
The CD8 beta polypeptide is required for the recognition of an altered peptide ligand as an agonist
-
Renard V, Delon J, Luescher IF, Malissen B, Vivier E, Trautmann A. The CD8 beta polypeptide is required for the recognition of an altered peptide ligand as an agonist. Eur J Immunol. 26:1996;2999-3007.
-
(1996)
Eur J Immunol
, vol.26
, pp. 2999-3007
-
-
Renard, V.1
Delon, J.2
Luescher, I.F.3
Malissen, B.4
Vivier, E.5
Trautmann, A.6
-
44
-
-
0028945329
-
Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4
-
Mannie M, Rosser J, White G. Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4. J Immunol. 154:1995;2642-2654.
-
(1995)
J Immunol
, vol.154
, pp. 2642-2654
-
-
Mannie, M.1
Rosser, J.2
White, G.3
-
45
-
-
0029862940
-
Endogenous altered peptide ligands can affect peripheral T cell responses
-
Vidal K, Hsu BL, Williams CB, Allen PM. Endogenous altered peptide ligands can affect peripheral T cell responses. J Exp Med. 183:1996;1311-1321.
-
(1996)
J Exp Med
, vol.183
, pp. 1311-1321
-
-
Vidal, K.1
Hsu, B.L.2
Williams, C.B.3
Allen, P.M.4
-
46
-
-
0031048822
-
The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands
-
of outstanding interest. This is a functional and biochemical analysis of the consequence of limiting the association of CD4 with the T-cell receptor (TCR) upon ligand engagement. The effect of preventing the involvement of CD4 was to alter the response to an individual peptide from that described for agonist peptides to that described for antagonist peptides. This study provides biochemical evidence for the participation of the co-receptor in a qualitative manner in the TCR signal transduction cascade.
-
Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. of outstanding interest J Exp Med. 185:1997;219-229 This is a functional and biochemical analysis of the consequence of limiting the association of CD4 with the T-cell receptor (TCR) upon ligand engagement. The effect of preventing the involvement of CD4 was to alter the response to an individual peptide from that described for agonist peptides to that described for antagonist peptides. This study provides biochemical evidence for the participation of the co-receptor in a qualitative manner in the TCR signal transduction cascade.
-
(1997)
J Exp Med
, vol.185
, pp. 219-229
-
-
Madrenas, J.1
Chau, L.A.2
Smith, J.3
Bluestone, J.A.4
Germain, R.N.5
-
47
-
-
0026613778
-
Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies
-
Cobbold SP, Qin S, Leong LY, Martin G, Waldmann H. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol Rev. 129:1992;165-201.
-
(1992)
Immunol Rev
, vol.129
, pp. 165-201
-
-
Cobbold, S.P.1
Qin, S.2
Leong, L.Y.3
Martin, G.4
Waldmann, H.5
-
48
-
-
0026806050
-
Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody
-
Pearson TC, Madsen JC, Larsen CP, Morris PJ, Wood KJ. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation. 54:1992;475-483.
-
(1992)
Transplantation
, vol.54
, pp. 475-483
-
-
Pearson, T.C.1
Madsen, J.C.2
Larsen, C.P.3
Morris, P.J.4
Wood, K.J.5
-
49
-
-
0026613777
-
Anti-CD4 monoclonal antibodies in therapy: Creation of nonclassical tolerance in the adult
-
Shizuru JA, Alters SE, Fathman SG. Anti-CD4 monoclonal antibodies in therapy: creation of nonclassical tolerance in the adult. Immunol Rev. 129:1992;105-130.
-
(1992)
Immunol Rev
, vol.129
, pp. 105-130
-
-
Shizuru, J.A.1
Alters, S.E.2
Fathman, S.G.3
-
50
-
-
0030896612
-
Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy
-
of outstanding interest. This study shows that engaging the TCR with non-stimulatory anti-CD3 antibodies, which fail to involve the co-receptors, induces anergy in the targeted T-cell population. These results have important implications for therapeutic modulation of T-cell responses in vivo.
-
Smith JA, Yun Tso J, Clark MR, Cole MS, Bluestone JA. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. of outstanding interest J Exp Med. 185:1997;1413-1422 This study shows that engaging the TCR with non-stimulatory anti-CD3 antibodies, which fail to involve the co-receptors, induces anergy in the targeted T-cell population. These results have important implications for therapeutic modulation of T-cell responses in vivo.
-
(1997)
J Exp Med
, vol.185
, pp. 1413-1422
-
-
Smith, J.A.1
Yun Tso, J.2
Clark, M.R.3
Cole, M.S.4
Bluestone, J.A.5
-
52
-
-
0027364273
-
Is CD8 dependence a true reflection of TCR affinity for antigen
-
Kwan Lim G, Ong T, Aosai F, Stauss H, Zamoyska R. Is CD8 dependence a true reflection of TCR affinity for antigen. Int Immunol. 5:1993;1219-1228.
-
(1993)
Int Immunol
, vol.5
, pp. 1219-1228
-
-
Kwan Lim, G.1
Ong, T.2
Aosai, F.3
Stauss, H.4
Zamoyska, R.5
-
53
-
-
0028298811
-
The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice
-
Auphan N, Curnow J, Guimezanes A, Langlet C, Malissen B, Mellor A, Schmitt-Verhulst A-M. The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice. Eur Immunol. 24:1994;1572-1577.
-
(1994)
Eur Immunol
, vol.24
, pp. 1572-1577
-
-
Auphan, N.1
Curnow, J.2
Guimezanes, A.3
Langlet, C.4
Malissen, B.5
Mellor, A.6
Schmitt-Verhulst A-M7
-
54
-
-
0030037691
-
Alterations in CD4 dependence accompany T cell development and differentiation
-
Yelon D, Spain LM, Lim K, Berg LJ. Alterations in CD4 dependence accompany T cell development and differentiation. Int Immunol. 8:1996;1077-1090.
-
(1996)
Int Immunol
, vol.8
, pp. 1077-1090
-
-
Yelon, D.1
Spain, L.M.2
Lim, K.3
Berg, L.J.4
-
55
-
-
0030639131
-
Influence on CD8 of TCR/CD3-generated signals in CTL clones and CTL precursor cells
-
of special interest. Biochemical evaluation of the differences in signalling between a CD8-independent and a CD8-dependent T-cell receptors (TCRs) expressed in cytotoxic T lymphocytes (CTL)-precursor cells and clones. The data indicate that the response of the former of stronger and more sustained than the latter, even when anti-CD3 antibodies are used as the stimulus, indicating these differences in signalling potential are acquired during development.
-
Anel A, Martinez Lorenzo MJ, Schmitt Verhulst AM, Boyer C. Influence on CD8 of TCR/CD3-generated signals in CTL clones and CTL precursor cells. of special interest J Immunol. 158:1997;19-28 Biochemical evaluation of the differences in signalling between a CD8-independent and a CD8-dependent T-cell receptors (TCRs) expressed in cytotoxic T lymphocytes (CTL)-precursor cells and clones. The data indicate that the response of the former of stronger and more sustained than the latter, even when anti-CD3 antibodies are used as the stimulus, indicating these differences in signalling potential are acquired during development.
-
(1997)
J Immunol
, vol.158
, pp. 19-28
-
-
Anel, A.1
Martinez Lorenzo, M.J.2
Schmitt Verhulst, A.M.3
Boyer, C.4
-
56
-
-
0030855425
-
The three-dimensional structure of a T-cell antigen receptor VaVb heterodimer reveals a novel arrangement of the Vb domain
-
of outstanding interest. The crystal structure of a CD8-dependent TCR which differs from other published TCR structures in the nature of its CDR3β loop. This TCR is predicted to have to undergo a structural change in order to bind its MHC - peptide ligand, and it will be interesting to determine whether this requirement for conformational modification will relate to its CD8 dependency.
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Housset D, Mazza G, Gregoire C, Piras C, Malissen B, Fontecilla-Camps JC. The three-dimensional structure of a T-cell antigen receptor VaVb heterodimer reveals a novel arrangement of the Vb domain. of outstanding interest EMBO J. 16:1997;4205-4216 The crystal structure of a CD8-dependent TCR which differs from other published TCR structures in the nature of its CDR3β loop. This TCR is predicted to have to undergo a structural change in order to bind its MHC - peptide ligand, and it will be interesting to determine whether this requirement for conformational modification will relate to its CD8 dependency.
-
(1997)
EMBO J
, vol.16
, pp. 4205-4216
-
-
Housset, D.1
Mazza, G.2
Gregoire, C.3
Piras, C.4
Malissen, B.5
Fontecilla-Camps, J.C.6
-
57
-
-
0029662223
-
An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex
-
Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 274:1996;209-219.
-
(1996)
Science
, vol.274
, pp. 209-219
-
-
Garcia, K.C.1
Degano, M.2
Stanfield, R.L.3
Brunmark, A.4
Jackson, M.R.5
Peterson, P.A.6
Teyton, L.7
Wilson, I.A.8
-
58
-
-
0029855347
-
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
-
Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature. 384:1996;134-141.
-
(1996)
Nature
, vol.384
, pp. 134-141
-
-
Garboczi, D.N.1
Ghosh, P.2
Utz, U.3
Fan, Q.R.4
Biddison, W.E.5
Wiley, D.C.6
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