Ligation of Cell Surface CD4 Inhibits Activation-Induced Death of Human T Lymphocytes at the Level of Fas Ligand Expression

Journal of Immunology

Volumn 159, Issue 11, 1997, Pages 5742-5749

  Oberg, Hans Heinrich ^a   Sanzenbacher, Ralf ^a   Lengl Janßen, Beate ^a   Dobmeyer, Thomas ^a   Flindt, Sven ^a   Janssen, Ottmar ^a   Kabelitz, Dieter ^a  

^a PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CYTOKINE; ENTEROTOXIN; ENTEROTOXIN A, STAPHYLOCOCCAL; FAS LIGAND; FASLG PROTEIN, HUMAN; GLYCOPROTEIN GP 120; INTERLEUKIN 16; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DEATH; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHOSPHORYLATION; STAPHYLOCOCCUS AUREUS;

ANTIBODIES; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL DEATH; CYTOKINES; ENTEROTOXINS; FAS LIGAND PROTEIN; HIV ENVELOPE PROTEIN GP120; HUMANS; INTERLEUKIN-16; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; STAPHYLOCOCCUS AUREUS;

EID: 0031296742     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 349:245.
2. + peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur. J. Immunol. 21:1963.
3. Wesselborg, S., O. Janssen, and D. Kabelitz. 1993. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 150:4338.
4. Janssen, O., S. Wesselborg, and D. Kabelitz. 1992. Immunosuppression by OKT3: induction of programmed cell death (apoptosis) as a possible mechanism of action. Transplantation 53:233.
5. Russell, J. J., C. L. White, D. Y. Loh, and P. Meleedy-Rey. 1992. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl. Acad. Sci. USA 88:2151.
6. Kabelitz, D., T. Pohl, and K. Pechhold. 1993. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol. Today 14:338.
7. Dhein, J., H. Walczak, C. Bäumler, K.-M. Debatin, and P. H. Krammer. 1995. Autocrine T cell suicide mediated by Apo-1/(Fas/CD95). Nature 373:438.
8. Brunner, T., J. Mogil, D. LaFace, N. J. Yoo, A. Mahboubi, F. Echeverri, S. J. Martin, W. R. Force, D. H. Lynch, C. F. Ware, and D. R. Green. 1995. Cell-autonomous Fas(CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T cell hybridomas. Nature 373:44.
9. Ju, S.-T., D. J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D. H. Sherr, B. Z. Stanger, and A. Marshak-Rothstein. 1995. Fas(CD95)/FasL interactions required for programmed cell death after T cell activation. Nature 373:444.
10. Suda, T., and S. Nagata. 1994. Purification and characterization of the Fas-ligand that induces apoptosis. J. Exp. Med. 179:873.
11. Stanger, B. Z., P. Leder, T.-H. Lee, E. Kim, and B. Seed. 1995. RIP: a novel protein containing a death domain that interacts with Fas/Apo-1 (CD95) in yeast and causes cell death. Cell 81:513.
12. Chinnaiyan, A. M., K. O'Rourke, M. Tewari, and V. M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505.
13. Kischkel, F. C., S. Hellbardt, I. Behrmann, M. Germer, M. Pawlita, P. H. Krammer, and M. E. Peter. 1995. Cytotoxicity-dependent APO-1 (Fas/ CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14:5579.
14. Muzio, M., A. M. Chinnaiyan, F. C. Kischkel, K. O'Rourke, A. Shevchenko. J. Ni, C. Scaffidi, J. D. Bretz, M. Zhang, R. Gentz, M. Mann, P. H. Krammer, M. E. Peter, and V. M. Dixit. 1996. FLICE, a novel FADD homologous ICE/ CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex. Cell 85:817.
15. Los, M., M. Van de Craen, L. C. Penning, H. Schenk, M. Westendorp, P. A. Baeuerle, W. Droge, P. H. Krammer, W. Fiers, and K. Schulze-Osthoff. 1995. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375:81.
16. Enari, M., H. Hug, and S. Nagata. 1995. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:78.
17. Anel, A., M. Bufeme, C. Boyer, A. M. Schmitt-Verhulst, and P. Golstein. 1994. T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur. J. Immunol. 24:2469.
18. Alderson, M. R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F. Ramsdell, and D. H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71.
19. Radyanyi, L. G., Y. Shi, H. Vaziri, A. Sharma, R. Dhala, G. B. Mills, and R. G. Miller. 1996. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J. Immunol. 156:1788.
20. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med. 175:331.
21. Newell, M. K., L. J. Haughn, C. R. Maroun, and M. H. Julius. 1990. Death of mature T cells by separate ligation of CD4 and the T cell receptor for antigen. Nature 347:286.
22. Banda, N. K., J. Bernier, D. K. Kurahara, R. Kurrle, N. Haigwood, R.-P. Sekaly, and T. H. Finkel. 1992. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp. Med. 176:1099.
23. Choy, E. H. S., J. Adjave, L. Forrest, G. H. Kingsley, and G. S. Panayi. 1993. Chimaeric anti-CD4 monoclonal antibody cross-linked by monocyte Fcγ receptor mediates apoptosis of human CD4 lymphocytes. Eur. J. Immunol. 23:2676.
24. Facchinetti, A., M. Panozzo, P. Penile, L. Tessarollo, and G. Biasi. 1992. In vivo and in vitro death of mature T cells induced by separate signals to CD4 and αβTCR. Immunobiology 185:380.
25. Oyaizu, N., T. W. McCloskey, M. Coronesi, N. Chirmule, V. S. Kalyanaraman, and S. Pahwa. 1993. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 82:3392.
26. Wang, Z.-Q., A. Dudhane, T. Orlikowsky, K. Clarke, X. Li, Z. Darzynkiewicz, and M. K. Hoffmann. 1994. CD4 engagement induces Fas antigen-dependent apoptosis of T cells in vivo. Eur. J. Immunol. 24:1549.
27. + T cells. Proc. Natl. Acad. Sci. USA 93:11014.
28. - and 'activating' memory T cells. Clin. Exp. Immunol. 95:195.
29. Amendola, A., G. Lombard, S. Oliverio, V. Colizzi, and M. Piacentini. 1994. HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. FEBS Lett. 339:258.
30. + T cells in the absence of TCR co-stimulation. Int. Immunol. 8:65.
31. lck. J. Exp. Med. 183:39.
32. Pechhold, K., D. Wesch, S. Schondelmaier, and D. Kabelitz. 1994. Primary activation of Vγ9-expressing γδ T cells by Mycobacteriurn tuberculosis: requirement for Th1-type CD4 T cell help and inhibition by IL-10. J. Immunol. 152: 4984.
33. + antigen-presenting cells. Int. Immunol. 4:1381.
34. Robertson, M. J., T. J. Manley, G. Pichert, C. Cameron, K. J. Cochran, H. Levine, and J. Ritz. 1995. Functional consequences of APO-1/Fas (CD95) antigen expression by normal and neoplastic hematopoietic cells. Leukemia Lymphoma 17: 51.
35. Janssen, O., B. Lengl-Janssen, H.-H. Oberg, M. J. Robertson, and D. Kabelitz. 1996. Induction of cell death via Fas (CD95, Apo-1) may be associated with but is not dependent on Fas-induced tyrosine phosphorylation. Immunol. Lett. 49:63.
36. Pechhold, K., T. Pohl, and D. Kabelitz. 1994. Rapid quantification of lymphocyte subsets in heterogeneous cell populations by flow cytometry. Cytometry 16:152.
37. Cruikshank, W. W., D. M. Center, N. Nisar, M. Wu, B. Natke, A. C. Theodore, and H. Kornfeld. 1994. Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression. Proc. Natl. Acad. Sci. USA 91:5109.
38. Alderson, M. R., T. W. Tough, E. Roux, K. A. Schooley, and D. H. Lynch. 1994. Regulation of apoptosis and T cell activation by Fas-specific mAb. Int. Immunol. 6:1799.
39. Center, D. M., H. Kornfeld, and W. W. Cruikshank. 1996. Interleukin 16 and its function as a CD4 ligand. Immunol. Today 17:476.
40. Foumel, S., P. Morel, J. P. Revillard, G. Lizard, and N. Bonnefoy-Berard. 1993. Inhibition of human T cell response to staphylococcal enterotoxin B by prior ligation of surface CD4 molecules. Cell. Immunol. 150:194.
41. Westendorp, M. O., R. Frank, C. Ochsenbauer, K. Snicker, J. Dhein, H. Walczak, K.-M. Debatin, and P. H. Krammer. 1995. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497.
42. Zheng, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377:348.
43. Chinnayan, A. M., K. O'Rourke, G. L. Yu, R. H. Lyons, M. Garg, R. D. Duan, L. Xing, R. Gentz, J. Ni, and V. M. Dixit. 1996. Signal transduction by DR-3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274:990.
44. Bodmer, J. L., K. Bums, P. Schneider, K. Hofmann, V. Steiner, M. Thome, T. Bomand, M. Hahne, M. Schröter, K. Becker, A. Wilson, L. E. Frence, J. L. Browning, H. R. MacDonald, and J. Tschopp. 1997. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity 6:79.
45. Pan, G., K. O'Rourke, A. M. Chinnayan, R. Gentz, R. Ebner, J. Ni, and V. M. Dixit. 1997. The receptor for the cytotoxic ligand TRAIL. Science 276:111.
46. Wiley, S. R., K. Schooley, P. J. Smolak, W. S. Din, C. P. Huang, J. K. Nicjoli, G. R. Sutherland, T. D. Smith, C. Rauch, C. A. Smith, and R. G. Goodwin. 1995. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3:673.
47. Pitti, R. M., S. A. Marsters, S. Ruppert, C. J. Donahue, A. Moore, and A. Ashkenazi. 1996. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271:12687.
48. Anderson, P., M.-L. Blue, C. Morimoto, and S. F. Schlossman. 1987. Crosslinking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes. J. Immunol. 139:678.
49. Oravecz, T., and M. A. Norcross. 1993. Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120. AIDS Res. Hum. Retroviruses 9:945.
50. Bank, I., and L. Chess. 1985. Perturbation of the T4 molecule transmits a negative signal to T cells. J. Exp. Med. 162:1294.
51. Mittler, R. S., and M. K. Hoffmann. 1989. Synergism between HIV gp120 and gp120-specific antibody in blocking human T cell activation. Science 245:1380.
52. Dianzani, U., A. Shaw, M. Fernandez-Cabezuda, and C. A. Janeway, Jr. 1992. Extensive CD4 cross-linking inhibits T cell activation by anti-receptor antibody but not by antigen. Int. Immunol. 4:995.
53. Liegler, T . J., and D. P. Stites. 1994. HIV-1 gp120 and anti-gp120 induce reversible unresponsiveness in peripheral CD4 T lymphocytes. J. Acquired Immune Defic. Syndr. 7:340.
54. Sékaly, R.-P., G. Croteau, M. Bowman, P. Scholl, S. Burakoff, and R. S. Geha. 1991. The CD4 molecule is not always required for the T cell response to bacterial enterotoxins. J. Exp. Med. 173:367.
55. Fleury, S., B. Huang, A. Zerbib, G. Croteau, E. O. Long, and R.-P. Sékaly. 1996. Mutations in human CD4 impair the functional interaction with different human and mouse class II isotypes and alleles. J. Immunol. 156:1848.
56. Yagi, J., J. Baron, S. Buxser, and C. A. Janeway. Jr. 1990. Bacterial proteins that mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC. J. Immunol. 144:892.
57. Oyaizu, N., N. Chirmule, H. Yagura, R. Pahwa, R. A. Good, and S. Pahwa. 1992. Superantigen staphylococcal enterotoxin B-induced T-helper cell activation is independent of CD4 molecules and phosphatidylinositol hydrolysis. Proc. Natl. head. Sci. USA 89:8035.
58. Cruikshank, W. W., K. Lim, A. C. Theodore, J. Cook, G. Fine, P. F. Weller, and D. M. Center. 1996. IL-16 inhibition of CD3-dependent lymphocyte activation and proliferation. J. Immunol. 157:5240.
59. Bazan, J. F., and T. J. Schall. 1996. Interleukin-16 or not? Scientific correspondence. Nature 381:29.
60. Bannert, N., M. Baier, A. Werner, and R. Kurth. 1996. Interleukin-16 or not? Scientific correspondence. Nature 381:30.
61. Baier, M., N. Bannert, A. Werner, K. Lang, and R. Kurth. 1997. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor. Proc. Natl. Acad. Sci. USA 94:5273.
62. Baldari, C. T., E. Milia, M. M. Di Somma, F. Baldoni, S. Valitutti, and J. L. Telford. 1995. Distinct signaling properties identify functionally different CD4 epitopes. Ear. J. Immunol. 25:1843.
63. lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration. J. Biol. Chem. 270:17081.
64. lck activation and TCR desensitization independent of TCR tyrosine phosphorylation. J. Immunol. 153:2905.
65. Jabado, N., A. Pallier, F. Le Deist, F. Bernard, A. Fischer, and C. Hivroz. 1997. CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation. J. Immunol. 158:94.
66. lck in T-cell receptor/CD3-mediated apoptosis and Fas-ligand induction in Jurkat cells. Biochem. Biophys. Res. Commun. 213:994.
67. Latinis, K. M., and G. A. Koretzky. 1996. Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and lck in human T cells. Blood 87:871.
68. Gonzalez-Garcia, A., L. R. Borlado, E. Leonardo, I. Merida, C. Martinez-A., and A. C. Carrera. 1997. Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells. J. Immunol. 158:4104.
69. Boehme, S. A., L. Zheng, and M. J. Lenardo. 1995. Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death. J. Immunol. 155:1703.
70. Moreland, L. W., P. W. Pratt, M. D. Mayes, A. Postlethwaite, M. H. Weisman, T. Schnitzer, R. Lightfoot, L. Calabrese, D. J. Zelinger, J. N. Woody, and W. J. Koopman. 1995. Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate. Arthritis Rheum. 38:1581.
71. O'Neill, J. K., D. Baker, A. N. Davison, S. J. Allen, C. Butter, H. Waldman, and J. L. Turk. 1993. Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies. J. Neuroimmunol. 45:1.
72. + T cell regulation during the induction phase of the response. Eur. J. Immunol. 25:2643.