메뉴 건너뛰기




Volumn 156, Issue 3, 1996, Pages 1020-1029

MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM IONOPHORE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

EID: 0030067653     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (126)

References (88)
  • 1
    • 0028038426 scopus 로고
    • MHC-dependent antigen processing and peptide presentation providing ligands for T lymphocyte activation
    • Germain, R N. 1994 MHC-dependent antigen processing and peptide presentation providing ligands for T lymphocyte activation Cell 76:287.
    • (1994) Cell , vol.76 , pp. 287
    • Germain, R.N.1
  • 2
    • 0025285280 scopus 로고
    • Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation
    • June, C H , M. C. Fletcher, J. A. Ledbetter, and L E. Samelson. 1990. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation J. Immunol. 144:1591.
    • (1990) J. Immunol. , vol.144 , pp. 1591
    • June, C.H.1    Fletcher, M.C.2    Ledbetter, J.A.3    Samelson, L.E.4
  • 3
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263.
    • (1994) Cell , vol.76 , pp. 263
    • Weiss, A.1    Littman, D.R.2
  • 4
    • 0026018057 scopus 로고
    • CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line
    • Park, D J., H. W. Rho, and S. G Rhee. 1991. CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line. Proc. Natl. Acad. Sci. USA 88:5453.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5453
    • Park, D.J.1    Rho, H.W.2    Rhee, S.G.3
  • 5
    • 0025835006 scopus 로고
    • T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1
    • Secrist, J. P., L Karnitz, and R. T Abraham 1994. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1. J Biol. Chem. 266:12135
    • (1994) J Biol. Chem. , vol.266 , pp. 12135
    • Secrist, J.P.1    Karnitz, L.2    Abraham, R.T.3
  • 6
    • 0026095639 scopus 로고
    • Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1
    • Weiss, A , G Koretzfcy, R. C. Schatzman, and T. Kadlecek. 1991. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proc. Natl Acad. Sci USA 88:5484
    • (1991) Proc. Natl Acad. Sci USA , vol.88 , pp. 5484
    • Weiss, A.1    Koretzfcy, G.2    Schatzman, R.C.3    Kadlecek, T.4
  • 9
    • 0024548313 scopus 로고
    • Contingent genetic regulatory events in T lymphocyte activation
    • Crabtree, G. R. 1989 Contingent genetic regulatory events in T lymphocyte activation. Science 243:355.
    • (1989) Science , vol.243 , pp. 355
    • Crabtree, G.R.1
  • 13
    • 0028245832 scopus 로고
    • A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells
    • Buday, L S , S. E. Egan, P. Rodriguez Viciana, D. A. Cantreli, and J Downward. 1994. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells J Biol Chem. 269:9019
    • (1994) J Biol Chem. , vol.269 , pp. 9019
    • Buday, L.S.1    Egan, S.E.2    Rodriguez Viciana, P.3    Cantreli, D.A.4    Downward, J.5
  • 14
    • 0028180585 scopus 로고
    • GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
    • Sieh, M , A. Batzer, J. Schlessinger, and A Weiss 1994 GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation Mol. Cell Biol 14:4435.
    • (1994) Mol. Cell Biol , vol.14 , pp. 4435
    • Sieh, M.1    Batzer, A.2    Schlessinger, J.3    Weiss, A.4
  • 15
    • 0027337561 scopus 로고
    • p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes
    • Izquierdo, M , S. J. Leevers, C. J. Marshall, and D. Cantrell. 1993. p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes J Exp. Med. 178:1199
    • (1993) J Exp. Med. , vol.178 , pp. 1199
    • Izquierdo, M.1    Leevers, S.J.2    Marshall, C.J.3    Cantrell, D.4
  • 16
    • 0028365578 scopus 로고
    • G-proteins in lymphocyte signalling
    • Cantrell, D. 1994. G-proteins in lymphocyte signalling Curr. Opin. Immunol. 6:380.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 380
    • Cantrell, D.1
  • 18
    • 0027527919 scopus 로고
    • Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells
    • Traverse, S., P. Cohen, H. Paterson, C. Marshall, U. Rapp, and R. J. A. Grand. 1993. Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells. Oncogene 8:3175.
    • (1993) Oncogene , vol.8 , pp. 3175
    • Traverse, S.1    Cohen, P.2    Paterson, H.3    Marshall, C.4    Rapp, U.5    Grand, R.J.A.6
  • 20
    • 0028272507 scopus 로고
    • Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
    • Leevers, S. J., H. F. Paterson, and C J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369:411.
    • (1994) Nature , vol.369 , pp. 411
    • Leevers, S.J.1    Paterson, H.F.2    Marshall, C.J.3
  • 21
    • 0028970393 scopus 로고
    • Raf-1 N-terminal sequences necessary for Ras-Raf-1 interaction and signal transduction
    • Pumiglia, K., Y. Chow, J. Fabian, D. Morrison, S. Decker, and R. Jove. 1995. Raf-1 N-terminal sequences necessary for Ras-Raf-1 interaction and signal transduction. Mol. Cell. Biol. 15:398.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 398
    • Pumiglia, K.1    Chow, Y.2    Fabian, J.3    Morrison, D.4    Decker, S.5    Jove, R.6
  • 22
    • 0028216315 scopus 로고
    • MAP kinases ERK1 and ERK2: Pleiotropic enzymes in a ubiquitous signaling network
    • Robbins, D. J , E. Zhen, M Cheng, S. Xu, D. Eben, and M. H. Cobb. 1994 MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network. Adv Cancer Res. 63:93.
    • (1994) Adv Cancer Res. , vol.63 , pp. 93
    • Robbins, D.J.1    Zhen, E.2    Cheng, M.3    Xu, S.4    Eben, D.5    Cobb, M.H.6
  • 24
    • 0027202110 scopus 로고
    • Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2
    • Wu, J., J. K Harrison, P. Dent, K. R Lynch, M J. Weber, and T. W Sturgill. 1993. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2 Mol. Cell Biol. 13:4539.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 4539
    • Wu, J.1    Harrison, J.K.2    Dent, P.3    Lynch, K.R.4    Weber, M.J.5    Sturgill, T.W.6
  • 25
    • 0026539931 scopus 로고
    • The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
    • Crews, C. M , A. Alessandrini, and R. L. Erikson. 1992. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258: 478.
    • (1992) Science , vol.258 , pp. 478
    • Crews, C.M.1    Alessandrini, A.2    Erikson, R.L.3
  • 26
    • 0026641090 scopus 로고
    • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro
    • Dent, P., W Haser, T. A. Haystead, L. A Vincent, T. M. Roberts, and T. W. Sturgill. 1992. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science 257.1404.
    • (1992) Science , vol.257 , pp. 1404
    • Dent, P.1    Haser, W.2    Haystead, T.A.3    Vincent, L.A.4    Roberts, T.M.5    Sturgill, T.W.6
  • 28
    • 0027394157 scopus 로고
    • Ras protein activity is essential for T-cell antigen receptor signal transduction
    • Baldari, C. T., A. Heguy, and J. L. Telford. 1993 Ras protein activity is essential for T-cell antigen receptor signal transduction. J. Biol. Chem. 268:2693.
    • (1993) J. Biol. Chem. , vol.268 , pp. 2693
    • Baldari, C.T.1    Heguy, A.2    Telford, J.L.3
  • 30
    • 0028287296 scopus 로고
    • The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor
    • Izquierdo, M., S. Bowden, and D. Cantrell. 1994. The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor. J. Exp. Med 180:401.
    • (1994) J. Exp. Med , vol.180 , pp. 401
    • Izquierdo, M.1    Bowden, S.2    Cantrell, D.3
  • 31
    • 0028222136 scopus 로고
    • A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum
    • Frost, J A., T. D. Geppert, M. H. Cobb, and J. R. Feramisco 1994. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proc Natl. Acad. Sci USA 91:3844.
    • (1994) Proc Natl. Acad. Sci USA , vol.91 , pp. 3844
    • Frost, J.A.1    Geppert, T.D.2    Cobb, M.H.3    Feramisco, J.R.4
  • 33
    • 0028270718 scopus 로고
    • Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation
    • Troppmair, J , J. T Bruder, H. Munoz, P. A. Lloyd, J. Kyriakis, P. Banerjee, J. Avruch, and U. R Rapp. 1994. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J. Biol. Chem. 269:7030.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7030
    • Troppmair, J.1    Bruder, J.T.2    Munoz, H.3    Lloyd, P.A.4    Kyriakis, J.5    Banerjee, P.6    Avruch, J.7    Rapp, U.R.8
  • 34
    • 0028201023 scopus 로고
    • Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases
    • Westwick, J K., A. D. Cox, C J. Der, M. H. Cobb, M. Hibi, M. Karin, and D A. Brenner. 1994. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc. Natl. Acad. Sci. USA 91:6030.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6030
    • Westwick, J.K.1    Cox, A.D.2    Der, C.J.3    Cobb, M.H.4    Hibi, M.5    Karin, M.6    Brenner, D.A.7
  • 35
    • 0028239101 scopus 로고
    • Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2
    • Kartenjann, M., O. Thornae, and P. E. Shaw. 1994. Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. Mol Cell. Biol. 14:4815
    • (1994) Mol Cell. Biol. , vol.14 , pp. 4815
    • Kartenjann, M.1    Thornae, O.2    Shaw, P.E.3
  • 37
    • 0026527505 scopus 로고
    • Analysis of the AP-1 sites in the IL-2 promoter
    • Jain, J., V. E Valge-Archer, and A. Rao. 1992. Analysis of the AP-1 sites in the IL-2 promoter. J. Immunol 148:1240.
    • (1992) J. Immunol , vol.148 , pp. 1240
    • Jain, J.1    Valge-Archer, V.E.2    Rao, A.3
  • 38
    • 0026596383 scopus 로고
    • Nuclear factor of activated T cells contains Fos and Jun
    • Jain, J , P. G. McCaffrey, V. E Valge-Archer, and A. Rao 1992 Nuclear factor of activated T cells contains Fos and Jun. Nature 356:801.
    • (1992) Nature , vol.356 , pp. 801
    • Jain, J.1    McCaffrey, P.G.2    Valge-Archer, V.E.3    Rao, A.4
  • 39
    • 0027518679 scopus 로고
    • Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
    • Northrop, J. P , K. S. Ullman, and G. R. Crabtree. 1993. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. J. Biol Chem 268:2917
    • (1993) J. Biol Chem , vol.268 , pp. 2917
    • Northrop, J.P.1    Ullman, K.S.2    Crabtree, G.R.3
  • 42
    • 0023712739 scopus 로고
    • Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
    • Yamamoto, K. K., G. A. Gonzalez, W. H Biggs III, and M. R. Montminy. 1988. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature 334.494.
    • (1988) Nature , vol.334 , pp. 494
    • Yamamoto, K.K.1    Gonzalez, G.A.2    Biggs III, W.H.3    Montminy, M.R.4
  • 44
    • 0028962328 scopus 로고
    • The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells
    • Whitehurst, C. E., H. Owaki, J. T. Brader, U. R. Rapp, and T. D. Geppert. 1995 The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells. J. Biol. Chem. 270:5594.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5594
    • Whitehurst, C.E.1    Owaki, H.2    Brader, J.T.3    Rapp, U.R.4    Geppert, T.D.5
  • 45
    • 0026570140 scopus 로고
    • cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein
    • Charles, C. H., A. S. Abler, and L F. Lau 1992 cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein Oncogene 7:187.
    • (1992) Oncogene , vol.7 , pp. 187
    • Charles, C.H.1    Abler, A.S.2    Lau, L.F.3
  • 46
    • 0025219114 scopus 로고
    • Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C
    • Nel, A E , C Hanekom, A. Rheeder, K. Williams, S. Pollack, R. Katz, and G. E Landreth. 1990. Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C. J. Immunol. 144:2683.
    • (1990) J. Immunol. , vol.144 , pp. 2683
    • Nel, A.E.1    Hanekom, C.2    Rheeder, A.3    Williams, K.4    Pollack, S.5    Katz, R.6    Landreth, G.E.7
  • 47
    • 0028208969 scopus 로고
    • Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes
    • Franklin, R. A., A. Tordai, H Patel, A. M. Gardner, G. L. Johnson, and E. W. Gelfand. 1994 Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes. J. Clin. Invest. 93: 2134.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2134
    • Franklin, R.A.1    Tordai, A.2    Patel, H.3    Gardner, A.M.4    Johnson, G.L.5    Gelfand, E.W.6
  • 48
    • 0026534209 scopus 로고
    • Extracellular signal regulated kinases in T cells: Anti-CD3 and 4B-phorbol 12-myristate 13-acetate-induced phosphorylation and activation
    • Whitehurst, C. E., T G. Boulton, M. H. Cobb, and T. D. Geppert. 1992 Extracellular signal regulated kinases in T cells: anti-CD3 and 4B-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. J Immunol 148:1230.
    • (1992) J Immunol , vol.148 , pp. 1230
    • Whitehurst, C.E.1    Boulton, T.G.2    Cobb, M.H.3    Geppert, T.D.4
  • 49
    • 0025255387 scopus 로고
    • Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function, the missing link
    • Ullman, K. S., J. P. Northrop, C. L. Verweij, and G R. Crabtree. 1990. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function, the missing link. Annu. Rev. Immunol. 8 421.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 421
    • Ullman, K.S.1    Northrop, J.P.2    Verweij, C.L.3    Crabtree, G.R.4
  • 50
    • 0027336340 scopus 로고
    • ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells
    • ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells. J. Immunol 150:3853.
    • (1993) J. Immunol , vol.150 , pp. 3853
    • Woodrow, M.A.1    Rayter, S.2    Downward, J.3    Cantrell, D.A.4
  • 51
    • 0027331410 scopus 로고
    • ras and calcineurin synergize to regulate the nuclear factor of activated T cells
    • ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178: 1517.
    • (1993) J. Exp. Med. , vol.178 , pp. 1517
    • Woodrow, M.1    Clipstone, N.A.2    Cantrell, D.3
  • 54
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of N1H3T3 cells
    • Cowley, S , H. Paterson, P. Kemp, and C. J. Marshall 1994 Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of N1H3T3 cells. Cell 77:841.
    • (1994) Cell , vol.77 , pp. 841
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 55
    • 0028359984 scopus 로고
    • Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase
    • Pages, G , A Brunet, G. L'Allemain, and J. Pouyssegur. 1994. Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase. EMBO J. 13.3003.
    • (1994) EMBO J. , vol.13 , pp. 3003
    • Pages, G.1    Brunet, A.2    L'Allemain, G.3    Pouyssegur, J.4
  • 56
    • 0027358722 scopus 로고
    • MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
    • Sun, H., C H. Charles, L F. Lau, and N K. Tonks. 1993. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:487
    • (1993) Cell , vol.75 , pp. 487
    • Sun, H.1    Charles, C.H.2    Lau, L.F.3    Tonks, N.K.4
  • 57
    • 0027376035 scopus 로고
    • Rapid activation of c-Raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T cells
    • Siegel, J. N., C H. June, H. Yamada, U. R. Rapp, and L. E. Samelson 1993. Rapid activation of c-Raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T cells. J Immunol. 151:4116.
    • (1993) J Immunol. , vol.151 , pp. 4116
    • Siegel, J.N.1    June, C.H.2    Yamada, H.3    Rapp, U.R.4    Samelson, L.E.5
  • 58
    • 0027182750 scopus 로고
    • Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells
    • Cause, K. C., M K Homma, K. A. Licciardi, R. Seger, N. G. Ahn, M. J. Peterson, E. G. Krebs, and K. E. Meier. 1993. Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. J. Biol. Chem. 268 16124.
    • (1993) J. Biol. Chem. , vol.268 , pp. 16124
    • Cause, K.C.1    Homma, M.K.2    Licciardi, K.A.3    Seger, R.4    Ahn, N.G.5    Peterson, M.J.6    Krebs, E.G.7    Meier, K.E.8
  • 60
    • 0028935974 scopus 로고
    • Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
    • Derijard, B., J. Raingeaud, T. Barrett, I. H. Wu, J. Han, R J. Ulevitch, and R J Davis 1995. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms Science 267:682.
    • (1995) Science , vol.267 , pp. 682
    • Derijard, B.1    Raingeaud, J.2    Barrett, T.3    Wu, I.H.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 61
    • 0027242125 scopus 로고
    • Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase
    • Kyriakis, J. M, T. L Force, U. R. Rapp, J. V. Bonventre, and J. Avruch. 1993. Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J. Biol. Chem. 268:16009.
    • (1993) J. Biol. Chem. , vol.268 , pp. 16009
    • Kyriakis, J.M.1    Force, T.L.2    Rapp, U.R.3    Bonventre, J.V.4    Avruch, J.5
  • 62
    • 0027428530 scopus 로고
    • Raf-1 forms a stable complex with MEK1 and activates MEK1 by serine phosphorylation
    • Huang, W., A. Alessandrini, C. M Crews, and R L. Erikson 1993 Raf-1 forms a stable complex with MEK1 and activates MEK1 by serine phosphorylation. Proc. Natl. Acad. Sci. USA 90.10947.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10947
    • Huang, W.1    Alessandrini, A.2    Crews, C.M.3    Erikson, R.L.4
  • 64
    • 0027242125 scopus 로고
    • Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase
    • Kyriakis, J M., T. L. Force, U R. Rapp, J. V. Bonventre, and J. Avruch. 1993. Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J Biol Chem 268:16009
    • (1993) J Biol Chem , vol.268 , pp. 16009
    • Kyriakis, J.M.1    Force, T.L.2    Rapp, U.R.3    Bonventre, J.V.4    Avruch, J.5
  • 66
    • 0028670788 scopus 로고
    • Activation of stress-activated protein kinases by MEKK1 phosphorylation of its activator SEK1
    • Yan, M , T. Dai, J. C. Deak, J. M. Kyriakis, L. I. Zon, J R. Woodgett, and D. J Templeton. 1994. Activation of stress-activated protein kinases by MEKK1 phosphorylation of its activator SEK1. Nature 372:798.
    • (1994) Nature , vol.372 , pp. 798
    • Yan, M.1    Dai, T.2    Deak, J.C.3    Kyriakis, J.M.4    Zon, L.I.5    Woodgett, J.R.6    Templeton, D.J.7
  • 67
    • 0027306121 scopus 로고
    • The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts
    • Alessi, D. R., C. Smythe, and S. M Keyse. 1993. The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts Oncogene 8.2015.
    • (1993) Oncogene , vol.8 , pp. 2015
    • Alessi, D.R.1    Smythe, C.2    Keyse, S.M.3
  • 68
    • 0028920561 scopus 로고
    • Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells
    • Duff, J. L., B. P. Monia, and B C. Berk 1995. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. J. Biol. Chem. 270:7161.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7161
    • Duff, J.L.1    Monia, B.P.2    Berk, B.C.3
  • 69
    • 0028924419 scopus 로고
    • Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress
    • Liu, Y., M. Gorospe, C. Yang, and N. J. Holbrook. 1995 Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. J Biol. Chem. 270:8377.
    • (1995) J Biol. Chem. , vol.270 , pp. 8377
    • Liu, Y.1    Gorospe, M.2    Yang, C.3    Holbrook, N.J.4
  • 70
    • 0028089986 scopus 로고
    • Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1
    • Sun, H , N. K. Tonks, and D. Bar-Sagi. 1994. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science 266:285.
    • (1994) Science , vol.266 , pp. 285
    • Sun, H.1    Tonks, N.K.2    Bar-Sagi, D.3
  • 71
    • 0026596576 scopus 로고
    • Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase
    • Bruder, J. T., G. Heidecker, and U. R. Rapp. 1992. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev 6:545.
    • (1992) Genes Dev , vol.6 , pp. 545
    • Bruder, J.T.1    Heidecker, G.2    Rapp, U.R.3
  • 72
    • 0024513104 scopus 로고
    • Expression of raf oncogenes activates the PEA1 transcription factor motif
    • Wasylyk, C , W Bohdan, G. Heidecker, M Huleihel, and U. R. Rapp. 1993. Expression of raf oncogenes activates the PEA1 transcription factor motif. Mol Cel. Biol. 9:2247.
    • (1993) Mol Cel. Biol. , vol.9 , pp. 2247
    • Wasylyk, C.1    Bohdan, W.2    Heidecker, G.3    Huleihel, M.4    Rapp, U.R.5
  • 75
    • 0027400610 scopus 로고
    • Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes
    • Ullman, K. S., J. P. Northrop, A. Adrmon, and G. R. Crabtree. 1993 Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Dev. 7.188.
    • (1993) Genes Dev. , vol.7 , pp. 188
    • Ullman, K.S.1    Northrop, J.P.2    Adrmon, A.3    Crabtree, G.R.4
  • 76
    • 9044241760 scopus 로고
    • Ternary complex factors: Growth factor regulated transcriptional activators
    • Treisman, R. 1993. Ternary complex factors: growth factor regulated transcriptional activators. Curr. Opin Genet. Dev 12:5097.
    • (1993) Curr. Opin Genet. Dev , vol.12 , pp. 5097
    • Treisman, R.1
  • 77
    • 0028931406 scopus 로고
    • ERK phosphorylation potentiates ELK-1-mediated ternary complex formation and transactivation
    • Gille, H., M. Kortenjann, O. Thornae, C Moomaw, C Slaughter, M. H. Cobb, and P. E Shaw. 1995. ERK phosphorylation potentiates ELK-1-mediated ternary complex formation and transactivation. EMBO J. 14:951.
    • (1995) EMBO J. , vol.14 , pp. 951
    • Gille, H.1    Kortenjann, M.2    Thornae, O.3    Moomaw, C.4    Slaughter, C.5    Cobb, M.H.6    Shaw, P.E.7
  • 78
    • 0027425113 scopus 로고
    • Activation of ternary complex factor Elk-1 by MAP kinases
    • Janknecht, R., W. H. Ernst, V. Pingoud, and A. Nordheim. 1993. Activation of ternary complex factor Elk-1 by MAP kinases EMBO J. 12:5097.
    • (1993) EMBO J. , vol.12 , pp. 5097
    • Janknecht, R.1    Ernst, W.H.2    Pingoud, V.3    Nordheim, A.4
  • 79
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
    • Angel, P., and M. Karin. 1991. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072:129.
    • (1991) Biochim. Biophys. Acta , vol.1072 , pp. 129
    • Angel, P.1    Karin, M.2
  • 81
    • 0028077503 scopus 로고
    • Analysis of IL-2 gene regulation in c-fos transgenic mice: Evidence for an enhancement of IL-2 expression in splenic T cells stimulated via TCR/CD3 complex
    • Ochi, Y., T. Koizumi, S. Kobayashi, J. Phuchareon, M. Hatano, M. Takada, Y. Tomita, and T. Tokuhisa. 1994. Analysis of IL-2 gene regulation in c-fos transgenic mice: evidence for an enhancement of IL-2 expression in splenic T cells stimulated via TCR/CD3 complex. J. Immunol 153:3485.
    • (1994) J. Immunol , vol.153 , pp. 3485
    • Ochi, Y.1    Koizumi, T.2    Kobayashi, S.3    Phuchareon, J.4    Hatano, M.5    Takada, M.6    Tomita, Y.7    Tokuhisa, T.8
  • 82
    • 0027339327 scopus 로고
    • NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs
    • McCaffrey, P. G., B. A Perrino, T. R. Soderling, and A. Rao. 1993. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs J. Biol. Chem. 268:3747.
    • (1993) J. Biol. Chem. , vol.268 , pp. 3747
    • McCaffrey, P.G.1    Perrino, B.A.2    Soderling, T.R.3    Rao, A.4
  • 83
    • 0028930843 scopus 로고
    • NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominately in the thymus
    • Masuda, E. S , Y. Naito, H. Tokumitsu, D. Campbell, F. Saito, C. Hannum, K. I. Arai, and N. Arai. 1995 NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominately in the thymus. Mol. Cell. Biol 15:2697
    • (1995) Mol. Cell. Biol , vol.15 , pp. 2697
    • Masuda, E.S.1    Naito, Y.2    Tokumitsu, H.3    Campbell, D.4    Saito, F.5    Hannum, C.6    Arai, K.I.7    Arai, N.8
  • 84
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specificity
    • Hill, C. S., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199
    • (1995) Cell , vol.80 , pp. 199
    • Hill, C.S.1    Treisman, R.2
  • 85
    • 0028074621 scopus 로고
    • Ras-dependent growth factor regulation of MBK kinase in PC12 cells
    • Lange-Carter, C. A., and G. L. Johnson. 1994. Ras-dependent growth factor regulation of MBK kinase in PC12 cells. Science 265:1438.
    • (1994) Science , vol.265 , pp. 1438
    • Lange-Carter, C.A.1    Johnson, G.L.2
  • 86
    • 0027938445 scopus 로고
    • c-Jun N-termmal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases
    • Minden, A., A. Lin, T. Smeal, B. Derijard, M. Cobb, R. Davis, and M Karin. 1994. c-Jun N-termmal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14:6683.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6683
    • Minden, A.1    Lin, A.2    Smeal, T.3    Derijard, B.4    Cobb, M.5    Davis, R.6    Karin, M.7
  • 87
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during costimulation of T lymphocytes
    • Su, B., E. Jacinto, M. Hibi, T. Kallunki, M Karin, and Y. Ben-Nenah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
    • (1994) Cell , vol.77 , pp. 727
    • Su, B.1    Jacinto, E.2    Hibi, M.3    Kallunki, T.4    Karin, M.5    Ben-Nenah, Y.6
  • 88
    • 0028859281 scopus 로고
    • Selective requirement for MAP kinase activation in thymocyte differentiation
    • Alberola-Ila, J., K. A. Forbush, R. Seger, E. G. Krebs, and R M. Perlmutter. 1995. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620
    • (1995) Nature , vol.373 , pp. 620
    • Alberola-Ila, J.1    Forbush, K.A.2    Seger, R.3    Krebs, E.G.4    Perlmutter, R.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.