Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections

Infection and Immunity

Volumn 67, Issue 11, 1999, Pages 5854-5862

  Rumbaugh, Kendra P ^a   Griswold, John A ^b   Iglewski, Barbara H ^c   Hamood, Abdul N ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; BACTERIUM DETECTION; BURN INFECTION; COLONY FORMING UNIT; GRAM NEGATIVE INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STRAIN DIFFERENCE;

EID: 0032755655     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.11.5854-5862.1999     Document Type: Article

References (48)

1. Ausübel, F., R. Brent, R. Kingston, D. Moor, J. Seidman, J. Smith, and K. Stauhle. 1988. Current protocols in molecular biology. Wiley Intersciences, New York, N.Y.
2. Bergen, G. A., and J. H. Shelhamer. 1996. Pulmonary infiltrates in the cancer patient. New approaches to an old problem. Infect. Dis. Clin. N. Am. 10: 297-325.
3. Berka, R. M., G. L. Gray, and M. L. Vasil. 1981. Studies of phospholipase C (heat-labile hemolysin) in Pseudomonas aeruginosa. Infect. Immun. 34:1071-1074.
4. Bodey, G. P., R. Bolivar, V. Fainstein, and L. Jadeja. 1983. Infections caused by Pseudomonas aeruginosa. Rev. Infect. Dis. 5:279-313.
5. Brint, J. M., and D. E. Ohman. 1995. Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI. another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J. Bacteriol. 177:7155-7163.
6. Chapon-Herve, V., M. Akrim, A. Latifi, P. Williams, A. Lazdunski, and M. Bally. 1997. Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa. Mol. Microbiol. 24:1169-1178.
7. Doring, G. 1993. Pseudomonas aeruginosa infection in cystic fibrosis patients, p. 245-273. In M. Campa, M. Bendinelli, and H. Friedman (ed.), Pseudomonas aeruginosa as an opportunistic pathogen. Plenum Press, New York, N.Y.
8. Eberhard, A., A. L. Burlingame, C. Eberhard, G. L. Kenyon, K. H. Nealson, and J. Oppenheimer. 1981. Structural identification of autoinducer of Photobacterium fischeri luciferase. Biochemistry 20:2444-2449.
9. Fichtenbaum, C. J., K. F. Woeltje, and W. G. Powderly. 1994. Serious Pseudomonas aeruginosa infections in patients infected with human immunodeficiency virus: a case-control study. Clin. Infect. Dis. 19:417-422.
10. Finch, R. G., D. I. Pritchard, B. W. Bycroft, P. Williams, S. Gordon, and A. B. Stewart. 1998. Quorum sensing: a novel target for anti-infective therapy. J. Antimicrob. Chemother. 42:569-571.
11. Fuqua, W. C., S. C. Winans, and E. P. Greenberg. 1994. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J. Bacteriol. 176:269-275.
12. Gambello, M. J., and B. H. Iglewski. 1991. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J. Bacteriol. 173:3000-3009.
13. Gambello, M. J., S. Kaye, and B. H. Iglewski. 1993. LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression. Infect. Immun. 61:1180-1184.
14. Gilligan, P. H. 1991. Microbiology of airway disease in patients with cystic fibrosis. Clin. Microbiol. Rev. 4:35-51.
15. Holder, I. A. 1993. Pseudomonas aeruginosa burn infections: pathogenesis and treatment, p. 275-295. In M. Campa, M. Bendinelli, and H. Friedman (ed.), Pseudomonas aeruginosa as an opportunistic pathogen. Plenum Press, New York, N.Y.
16. Holloway, B. W., V. Krishnapillai, and A. F. Morgan. 1979. Chromosomal genetics of Pseudomonas. Microbiol. Rev. 43:73-102.
17. Homma, J. Y. 1980. Roles of exoenzymes and exotoxin in the pathogenicity of Pseudomonas aeruginosa and the development of a new vaccine. Jpn. J. Exp. Med. 50:149-165.
18. Latifi, A., M. Foglino, K. Tanaka, P. Williams, and A. Lazdunski. 1996. A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhlR (VsmR) to expression of the stationary-phase sigma factor RpoS. Mol. Microbiol. 21:1137-1146.
19. Mahenthiralingam, E., M. E. Campbell, and D. P. Speert 1994. Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect. Immun. 62:596-605.
20. May, T. B., and A. M. Chakrabarty. 1994. Pseudomonas aeruginosa: genes and enzymes of alginate synthesis. Trends Microbiol. 2:151-157.
21. McManus, A. T., A. D. Mason, Jr., W. F. McManus, and B. A. Pruitt, Jr. 1985. Twenty-five year review of Pseudomonas aeruginosa bacteremia in a burn center. Eur. J. Clin. Microbiol. 4:219-223.
22. Nicas, T. I., and B. H. Iglewski. 1985. The contribution of exoproducts to virulence of Pseudomonas aeruginosa. Can. J. Microbiol. 31:387-392.
23. Ochsner, U. A., A. K. Koch, A. Fiechter, and J. Relser. 1994. Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J. Bacteriol. 176:2044-2054.
24. Ochsner, U. A., and J. Relser. 1995. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92:6424-6428.
25. Ohman, D. E., R. P. Burns, and B. H. Iglewski. 1980. Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa. J. Infect. Dis. 142:547-555.
26. Passador, L., J. M. Cook, M. J. Gambello, L. Rust, and B. H. Iglewski. 1993. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 260:1127-1130.
27. Pavlovskis, O. R., and B. Wretlind. 1979. Assessment of protease (elastase) as a Pseudomonas aeruginosa virulence factor in experimental mouse burn infection. Infect. Immun. 24:181-187.
28. Pearson, J. P., K. M. Gray, L. Passador, K. D. Tucker, A. Eberhard, B. H. Iglewski, and E. P. Greenberg. 1994. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc. Natl. Acad. Sci. USA 91:197-201.
29. Pearson, J. P., L. Passador, B. H. Iglewski, and E. P. Greenberg. 1995. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92:1490-1494.
30. Pearson, J. P., E. C. Pesci, and B. H. Iglewski. 1997. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J. Bacteriol. 179:5756-5767.
31. Pesci, E. C., and B. H. Iglewski. 1997. The chain of command in Pseudomonas quorum sensing. Trends Microbiol. 5:132-134. (Discussion, 5:134-135.)
32. Pesci, E. C., and B. H. Iglewski. 1997. The chain of command in Pseudomonas quorum sensing. Trends Microbiol. 5:132-134. (Discussion, 5:134-135.)
33. Pesci, E. C., J. P. Pearson, P. C. Seed, and B. H. Iglewski. 1997. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179:3127-3132.
34. Preston, M. J., P. C. Seed, D. S. Toder, B. H. Iglewski, D. E. Ohman, J. K. Gustin, J. B. Goldberg, and G. B. Pier. 1997. Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. Infect. Immun. 65:3086-3090.
35. Rumbaugh, K. P., J. A. Griswold, and A. N. Hamood. 1999. Contribution of the regulatory gene lasR to the pathogenesis of Pseudomonas aeruginosa infection of burned mice. J. Burn Care Rehabil. 20:42-49.
36. Rumbaugh, K. P., J. A. Griswold, and A. N. Hamood. Unpublished data.
37. Saelinger, C. B., K. Snell, and I. A. Holder. 1977. Experimental studies on the pathogenesis of infections due to Pseudomonas aeruginosa: direct evidence for toxin production during Pseudomonas infection of burned skin tissues. J. Infect. Dis. 136:555-561.
38. Salmond, G. P., B. W. Bycroft, G. S. Stewart, and P. Williams. 1995. The bacterial 'enigma': cracking the code of cell-cell communication. Mol. Microbiol. 16:615-624.
39. Simpson, D. A., R. Ramphal, and S. Lory. 1992. Genetic analysis of Pseudomonas aeruginosa adherence: distinct genetic loci control attachment to epithelial cells and mucins. Infect. Immun. 60:3771-3779.
40. Smith, A. W., and B. H. Iglewski. 1989. Transformation of Pseudomonas aeruginosa by electroporation. Nucleic Acids Res. 17:10509.
41. Steel, R. G., and J. H. Torrie. 1980. Principles and procedures of statistics: a biometrical approach, second edition. McGraw-Hill, Inc., New York, N.Y.
42. Stieritz, D. D., and I. A. Holder. 1975. Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: description of a burned mouse model. J. Infect. Dis. 131:688-691.
43. Tang, H. B., E. DiMango, R. Bryan, M. Gambello, B. H. Iglewski, J. B. Goldberg, and A. Prince. 1996. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect. Immun. 64:37-43.
44. Toder, D. S., M. J. Gambello, and B. H. Iglewski. 1991. Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR. Mol. Microbiol. 5:2003-2010.
45. Van Delden, C., and B. H. Iglewski. 1998. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg. Infect. Dis. 4:551-560.
46. Van Delden, C., E. C. Pesci, J. P. Pearson, and B. H. Iglewski. 1998. Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant. Infect. Immun. 66:4499-4502.
47. Woods, D. E., and B. H. Iglewski. 1983. Toxins of Pseudomonas aeruginosa: new perspectives. Rev. Infect. Dis. 5(Suppl. 4):S715-S722.
48. Woods, D. E., P. A. Sokol, L. E. Bryan, D. G. Storey, S. J. Mattingly, H. J. Vogel, and H. Ceri. 1991. In vivo regulation of virulence in Pseudomonas aeruginosa associated with genetic rearrangement. J. Infect. Dis. 163:143-149.