The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3- Oxododecanoyl)-L-homoserine lactone has immunomodulatory activity

Infection and Immunity

Volumn 66, Issue 1, 1998, Pages 36-42

  Telford, Gary ^a,b   Wheeler, D ^a   Williams, Paul ^a   Tomkins, P T ^b   Appleby, P ^b   Sewell, Herbert ^c   Stewart, Gordon S A B ^a   Bycroft, Barrie W ^a   Pritchard, David I ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ABBOTT LABORATORIES   (United States)

^c NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; HOMOSERINE; IMMUNOGLOBULIN E; INTERLEUKIN 12; INTERLEUKIN 4; KEYHOLE LIMPET HEMOCYANIN; LACTONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; BACTERIAL VIRULENCE; CELL COMMUNICATION; CELL DENSITY; CELL POPULATION; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKEMIA CELL LINE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SIGNAL TRANSDUCTION; SPLEEN CELL;

EID: 0031975582     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.1.36-42.1998     Document Type: Article

References (35)

1. Bainbridge, T., and R. D. Fick. 1989. Functional importance of cystic fibrosis immunoglobulin fragments generated by Pseudomonas aeruginosa elastase. J. Lab. Clin. Mcd. 114:728-733.
2. Bainton, N. J., B. W. Bycroft, S. R. Chhabra, P. Stead, L. Gledhill, L. P. J. Hill, C. E. D. Rees, M. K. Winson, G. P. C. Salmond, G. S. A. B. Stewart, and P. Williams. 1992. A general role for the lux autoinducer in bacterial cell signalling: control of antibiotic biosynthesis in Ewinia. Gene 116:87-91.
3. Buret, A., M. L. Dunkley, G. Pang, R. L. Clancy, and A. W. Cripps. 1994. Pulmonary immunity to Pseudomonas aeruginosa in intestinally immunized rats: roles of alveolar macrophages, tumor necrosis factor alpha, and interleukin-1α. Infect. Immun. 62:5335-5343.
4. Cheng, H. C., H. Nishio, O. Hatase, S. Ralph, and J. H. Wang. 1992. A synthetic peptide derived from p34 cdc 2 is a specific and efficient substrate of src-family tyrosine kinases. J. Biol. Chem. 267:9248-9256.
5. Chhabra, S. R., P. Stead, N. J. Bainton, G. P. C. Salmond, G. S. A. B. Stewart, P. Williams, and B. W. Bycroft. 1993. Autoregulation of carbapenem biosynthesis in Erwinia carotovora ATCC 39048 by analogues of N-(3-oxohexanoyl)-L-homoserine lactone. J. Antibiot. 46:441-454.
6. Cripps, A. N., M. L. DunkJey, R. L. Clancy, and J. Kyd. 1995. Pulmonary immunity to Pseudomonas aemginosa. Immunol. Cell Biol. 73:418-424.
7. Decker, T., and M. L. Lohmann-Matthews. 1988. A quick and simple method for the quantitation of lactale dehydrogenase release in measurements of cellular cytotoxicity and tumour necrosis factor (TNF) activity. J. Immunol. Methods 15:61-69.
8. Dimango, E., H. J. Zar, R. Bryan, and A. Prince. 1995. Diverse Pseudomonas aemginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J. Clin. Invest. 5:2204-2210.
9. Eberhard, A., A. L. Burlingame, C. Eberhard, G. L. Kenyon, K. H. Nealson, and N. J. Oppenheimer. 1981. Structural identification of autoinducer of Photobacterium fischeri luciferase. Biochemistry 20:2444-2449.
10. Fuqua, W. C., S. C. Winans, and E. P. Greenberg. 1994. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J. Bacteriol. 176:269-275.
11. Galloway, D. R. 1991. Pseudomonas aeruginosa elastase and clastolysis revisited: recent developments. Mol. Microbiol. 5:2315-2321.
12. Jaffar-Bandjee, M. C., A. Lazdunski, M. Bally, J. Carrère, J. P. Chazalette, and C. Galabert. 1995. Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa. J. Clin. Microbiol. 33:924-929.
13. Jahr, T. G., L. Ryan, A. Sundan, H. S. Lichenstein, G. Skjåk-Bræk, and T. Espevik. 1997. Induction of tumor necrosis factor production from monocytes stimulated with mannuronic acid polymers and involvement of lipopolysaccharide-binding protein, CD14, and bactericidal/permeability-increasing factor. Infect. Immun. 65:89-94.
14. Jones, S., B. Yu, N. J. Bainton, M. Birdsall, B. W. Bycroft, S. R. Chhabra, A. J. R. Cox, P. Golby, P. J. Reeves, S. Stephens, M. K. Winson, G. P. C. Salmond, G. S. A. B. Stewart, and P. Williams. 1993. The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa. EMBO J. 12:2477-2482.
15. Latifi, A., M. K. Winson, M. Foglino, B. W. Bycroft, G. S. A. B. Stewart, A. Lazdunski, and P. Williams. 1995. Multiple homologues of LuxR and Luxl control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PA01. Mol. Microbiol. 17:333-343.
16. Li, J.-D., A. F. Dohrman, M. Gallup, S. Miyata, J. R. Gum, Y. S. Kini, J. A. Nadel, A. Prince, and C. B. Basbaum. 1997. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc. Natl. Acad. Sci. USA 94:967-972.
17. Meighen, E. A. 1994. Genetics of bacterial bioluminescence. Annu. Rev. Genet. 28:117-139.
18. Morissette, C., C. Francoeur, C. Darmond-Zwaig, and F. Gervais. 1996. Lung phagocyte bactericidal function in strains of mice resistant and susceptible to Pseudomonas aeruginosa. Infect. Immun. 64:4984-4992.
19. Palfreyman, R. W., M. L. Watson, C. Eden, and A. W. Smith. 1997. Induction of biologically active interleukin-8 from lung epithelial cells by Burkholderia (Pseudomonas) cepacia products. Infect. Immun. 65:617-622.
20. Passador, L., J. M. Cook, M. J. Gambello, L. Rust, and B. H. Iglewski. 1993. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 260:1127-1130.
21. Passador, L., and B. H. Iglewski. 1995. Quorum sensing and virulence gene regulation in Pseudomonas aeruginosa, p. 65-78. In J. A. Roth, C. A. Bolin, K. A. Brogden, F. C. Minion, and M. J. Wannemuehler (ed.), Virulence mechanisms of bacterial pathogens, 2nd ed. ASM Press, Washington, D.C.
22. Pearson, J. P., K. M. Gray, L. Passador, K. D. Tucker, A. Eberhard, B. H. Iglewski, and E. P. Greenberg. 1994. Structure of the autoinducer required for expression of the Pseudomonas aeruginosa virulence genes. Proc. Natl. Acad. Sci. USA 91:197-201.
23. Peurson, J. P., L. Passador, B. H. Iglewski, and E. P. Greenberg. 1995. A second N-acylhomoserine laetone signal produced by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92:1490-1494.
24. Pritchard, D. I., C. E. Lawrence, P. Appleby, I. A. Gibb, and K. Glover. 1994. Immunosuppressive proteins secreted by the gastrointestinal nematode parasite Heligmosomoides polygyrus. Int. J. Parasitol. 24:495-500.
25. Pritchard, D. I., and R. Moqbel. IgE, helminth infection, and the benefits of an allergic response. Is allergy a hangover from parasilism? Parasitology, in press.
26. Salmond, G. P. C., B. W. Bvcroft, G. S. A. B. Stewart, and P. Williams. 1995. The bacterial enigma: cracking the code of cell-cell communication. Mol. Microbiol. 16:615-624.
27. Stevenson, M. M., T. K. Kondratieva, A. S. Apt, M. F. Tam, and E. Skameme. 1996. In vitro and in vivo T cell responses in mice during broncho pulmonary infection with mucoid Pseudomonas aeruginosa. Clin. Exp. Immunol. 99:98-105.
28. Swift, S., M. K. Winson, P. F. Chan, N. J. Bainton, M. Birdsall, P. J. Reeves, C. E. D. Rees, S. R. Chhabra, P. J. Hill, J. P. Throup, B. W. Bycroft, G. P. C. Salmond, P. Williams, and G. S. A. B. Stewart. 1993. A novel strategy for the isolation of luxI homologues: evidence for the widespread distribution of a LuxR:LuxI superfamily in enteric bacteria. Mol. Microbiol. 10:511-520.
29. Swift, S., J. P. Throup, G. P. C. Salmond, P. Williams, and G. S. A. B. Stewart. 1996. Quorum sensing: a population-density component in the determination of bacterial phenotype. Trends Biochem. Sci. 21:214-219.
30. Throup, J. P., M. Camara, G. S. Briggs, M. K. Winson, S. R. Chhabra, B. W. Bycroft, P. Williams, and G. S. A. B. Stewart. 1995. Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two N-acyl-homoserine lactone signal molecules. Mol. Microbiol. 17:345-356.
31. Tomkins, P. T., K. L. Cooper, S. A. Titchmarsh, P. Appleby, and D. D. Webber. 1995. BTS 71 412: in vitro profile of a novel pyrazolinone immunosuppressant. Int. J. Immunopharmacol. 17:357-366.
32. Vassalli, P. 1992. The pathophysiology of tumour necrosis factors. Annu. Rev. Immunol. 10:411.
33. Wheeler, D. J., R. A. Robins, D. I. Pritchard, R. V. Bundick, and F. Shakib. 1996. Peripheral blood based T cell containing and T cell-depleted culture systems for human IgE synthesis: the role of T cells. clin. Exp. Allergy 26:28-35.
34. Williams. P., G. S. A. B. Stewart, M. Camara, M. K. Winson, S. R. Chhahra, G. P. Salmond, and B. W. Bycroft. 1996. Signal transduction through quorum sensing in Pseudomonas aeruginosa, p. 195-206. In T. Nakazawa, K. Furukawa, D. Haas, and S. Silver (ed.), Pseudomonas: molecular biology and biotechnology. American Society for Microbiology, Washington, D.C.
35. Winson, M. K., M. Camara, A. Latift, M. Foglino, S. R. Chhabra, M. Daykin, M. Bally, V. Chapon, G. P. C. Salmond, B. W. Bycroft, A. Lazdunski, G. S. A. B. Stewart, and P. Williams. 1995. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92:9427-9431.