Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN

Journal of Immunology

Volumn 166, Issue 4, 2001, Pages 2291-2295

  Kadowaki, N ^a   Antonenko, S ^a   Liu, Y J ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BACTERIAL DNA; CD11 ANTIGEN; DOUBLE STRANDED RNA; INTERFERON; NUCLEIC ACID; OLIGODEOXYNUCLEOTIDE; PALINDROMIC DNA; POLYINOSINIC POLYCYTIDYLIC ACID; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INTERFERON PRODUCTION; MONOCYTE; PRIORITY JOURNAL; STEM CELL;

EID: 0035865228     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.4.2291     Document Type: Article

References (40)

1. Innate immunity: Impact on the adaptive immune response
2. The role of dendritic cells in the induction and regulation of immunity to microbial infection
3. Dendritic cells and the control of immunity
4. The role of CpG motifs in innate immunity
5. When two strands are better than one: The mediators and modulators of the cellular responses to double-stranded RNA
6. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
7. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
8. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
9. Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells
10. Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro
11. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity
12. Oligodeoxyribonucleotides with 5′-ACGT-3′ or 5′-TCGA-3′ sequence induce production of interferons
13. Interferon induction by polynucleotides, modified polynucleotides, and polycarboxylates
14. Induction of interferon in vivo and in vitro by polynucleotides and derivatives, and preparation of derivatives
15. Biological properties of recombinant α-interferons: 40th anniversary of the discovery of interferons
16. Type I interferon-mediated stimulation of T cells by CpG DNA
17. Type I interferons keep activated T cells alive
18. In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production
19. Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs
20. The nature of the principal type I interferon-producing cells in human blood
21. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
22. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
23. Natural interferon α/β-producing cells link innate and adaptive immunity
24. Mechanism and function of a newly identified CpG DNA motif in human primary B cells
25. DNA activates human immune cells through a CpG sequence-dependent manner
26. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
27. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
28. CpG motifs in bacterial DNA trigger direct B-cell activation
29. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
30. Hexamer palindromic oligonucleotides with 5′-CG-3′ motif(s) induce production of interferon
31. Expression of pTα mRNA in a committed dendritic cell precursor in the human thymus
32. Immune recognition of foreign DNA: A cure for bioterrorism?
33. CpG DNA in cancer immunotherapy
34. Effects of CpG DNA on Th1/Th2 balance in asthma
35. Innate immunity: The virtues of a nonclonal system of recognition
36. Macrophages ingest and are activated by bacterial DNA
37. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
38. JNK2 and IKKβ are required for activating the innate response to viral infection
39. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
40. Toll-like receptors in the induction of the innate immune response