Nitric oxide synthase-I containing cortical interneurons co-express antioxidative enzymes and anti-apoptotic Bcl-2 following focal ischemia: Evidence for direct and indirect mechanisms towards their resistance to neuropathology

Journal of Chemical Neuroanatomy

Volumn 22, Issue 3, 2001, Pages 167-184

  Bidmon, Hans J ^a   Emde, Barbara ^a   Kowalski, Tilo ^a   Schmitt, Marcus ^a   Mayer, Bernd ^c   Kato, Kanefusa ^d   Asayama, Kohtaro ^e   Witte, Otto W ^a   Zilles, Karl ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c UNIVERSITY OF GRAZ   (Austria)

^d INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^e UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Apoptosis; Brain; Cyclooxygenase; Glutathione peroxidase; Heme oxygenase; Superoxide dismutase

Indexed keywords

ANTIOXIDANT; CASPASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GLUTATHIONE PEROXIDASE; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 2; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PROSTAGLANDIN G2; PROTEIN BCL 2; SUPEROXIDE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN CORTEX; BRAIN ISCHEMIA; CELL DAMAGE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME MECHANISM; ENZYME REGULATION; GLIA; IMMUNOCYTOCHEMISTRY; INTERNEURON; MALE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN ISCHEMIA; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; GLUTATHIONE PEROXIDASE; HEME OXYGENASE (DECYCLIZING); IMMUNOHISTOCHEMISTRY; INTERNEURONS; MALE; MICROSCOPY, CONFOCAL; NERVE DEGENERATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 0034884315     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-0618(01)00126-0     Document Type: Article

References (147)

1. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
2. Immunohistchemical localization and quantitative analysis of cellular glutathione peroxidase in foetal and neonatal rat tissues: Fluorescence microscopy image analysis
3. Mechanisms underlying hypoxia-induced neuronal apoptosis
4. The molecular mechanisms of cerebral ischemia: The possible therapeutic interventions
5. Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum
6. Homocysteic acid lesions in rat striatum spare somatostatin-neuropeptide Y (NADPH-diaphorase) neurons
7. The physiology and pathophysiological chemistry of nitric oxide
8. 4 binding are markers for associative and transhemispheric diaschisis in the rat
9. Nitric oxide synthase-expressing neurons are area-specific distributed within the cerebral cortex of the rat
10. Structural alterations and changes in cytoskeletal proteins and proteoglycans after focal cortical ischemia
11. Transient increase of manganese superoxide dismutase in remote brain areas following photothrombotic cortical lesion
12. Transient changes in the presence of NO-synthases and nitrotyrosine immunoreactivity after focal cortical ischemia
13. Unilateral upregulation of cyclooxygenase-2 (COX-2) following cerebral, cortical photothrombosis in the rat: Suppression by MK-801 and co-distribution with enzymes involved in the oxidative stress cascade
14. Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis
15. Induction of nitric oxide synthase inhibits gap junction permeability in cultured rat astrocytes
16. Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance
17. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α-syntrophin mediated by PDZ domains
18. Tissue-specific functions of individual glutathione peroxidases
19. Nonenzymatic antioxidant defense systems
20. Neuronal nitric oxide synthase expression is induced in neocortical astrocytes after spreading depression
21. Synaptic transmission in the striatum: From plasticity to neurodegeneration
22. Localization of nitric oxide synthase in the tree shrew retina
23. Ultrastructural changes in nitric oxide synthase immunoreactivity in the brain of rats subjected to perinatal asphyxia: Neuroprotective effects of cold treatment
24. Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage
25. Differential expression of AMPA receptor subunits in NOS-positive neurons of cortex, striatum, and hippocampus
26. Role of oxidants in ischemic brain damage
27. Hydroperoxide metabolism in mammalian organs
28. Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia
29. Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein
30. Neuroprotective properties of nitric oxide
31. Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: An immunohistochemical study
32. Chemical anatomy of striatal interneurons in normal individuals and in patients with Huntington's
33. Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase
34. Regional distribution of prostaglandin H synthase-2 and neuronal nitric oxide synthase in piglet brain
35. Effects of anoxic stress on prostaglandin H synthase isoforms in piglet brain
36. Regulation and role of heme oxygenase in oxidative injury
37. Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: Effect of lubeluzole
38. NO-mediated cGMP synthesis in cholinergic neurons in the rat forebrain: Effects of lesioning dopaminergic or serotonergic pathways on nNOS and cGMP synthesis
39. Pathobiology of ischaemic stroke: An integrated view
40. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
41. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage
42. Oxidative stress in the context of acute cerebrovascular stroke
43. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
44. Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawal
45. Histochemical localization of heme oxygenase-2 protein and mRNA expression in rat brain
46. Colocalization of somatostatin, neuropeptide Y, neuronal nitric oxide synthase and NADPH-diaphorase in striatal interneurons in rats
47. Multiple types of nitrogen monoxide synthase-/NADPH diaphorase containing neurons in human cerebral cortex
48. Iron as a vulnerability factor in nigrostriatal degeneration in aging and Parkinson's disease
49. Immunohistochemical localization of xanthine oxidase in human retina
50. Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia
51. Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice
52. Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation
53. Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia
54. Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity
55. Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency
56. Biologic and pharmacologic regulation of mammalian glutathione synthesis
57. Inactivation of antioxidant enzymes by peroxynitrite
58. Early and sequential recruitment of apoptotic effectors after focal permanent ischemia in mice
59. Oxidative stress, nutrition and health - Experimental strategies for optimization of nutritional antioxidant intake in humans
60. An improved method for avulsion of lumbar nerve roots as an experimental model of nitric oxide-mediated neuronal degeneration
61. C. elegans cell survival gene CED-9 encodes a functional homolog of the mammalian proto-oncogene BCL-2
62. Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter
63. The genetics of programmed cell death in the nematode Caenorhabditis elegans
64. Increased neurons containing neuronal nitric oxide synthase in the brain of a hypoxic-ischemic neonatal rat model
65. Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals
66. Localization of Mn-superoxide dismutase (Mn-SOD) in cholinergic and somatostatin-containing neurons in the rat neostriatum
67. Intense immunoreactivity for Mn-superoxide dismutase (Mn-SOD) in cholinergic and non-cholinergic neurons in the rat basal forebrain
68. Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat
69. Ontogeny of NADPH-diaphorase in rat forebrain and midbrain
70. Protein S-nitrosylation: A physiological signal for neuronal nitric oxide
71. The role of iron in neurodegeneration: Prospects for pharmacotherapy of Parkinson's disease
72. Cellular antioxidant and pro-oxidant actions of nitric oxide
73. Cyclooxygenase-2: Its rich diversity of roles and possible application of its selective inhibitors
74. Free radicals in biology: Sources, reactivities, and roles in the etiology of human disease
75. Expression of superoxide dismutase messenger RNA in adult rat brain cholinergic neurons
76. Cycloheximide reduces the size of lesion caused in rats by a photothrombotic model of brain injury
77. -
78. An immunocytochemical study of mitochondrial manganese-superoxide dismutase in the rat hippocampus after kainate administration
79. Upregulation of bax protein levels in neurons following cerebral ischemia
80. Expression of NMDA receptor-1 (NR-1) and Huntington in striatal neurons which colocalize somatostatin, neuropeptide Y, and NADPH diaphorase: A double-label histochemical and immunohistochemical study
81. Sensitive enzyme immunoassay for rat Mn superoxide dismutase: Tissue distribution and developmental profiles in the rat central nervous tissue, liver, and kidney
82. Enhanced cellular glutathione peroxidase immunoreactivity in activated astrocytes and in microglia during excitotoxin induced neurodegeneration
83. Ischemic cell death in brain neurons
84. Calcium, free radicals and excitotoxins in neuronal apoptosis
85. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
86. Protection of nitrergic neurotransmission by and colocalization of neural nitric oxide synthase with copper zinc superoxide dismutase
87. Direct evidence of nitric oxide presence within mitochondria
88. Delayed mitochondrial dysfunction in excitotoxic neuron death: Cytochrome c release and a secondary increase in superoxide production
89. HIV-1 coat glycoprotein gp120 induces apoptosis in rat brain neocortex by deranging the arachidonate cascade in favor of prostanoids
90. Gene expression induced by cerebral ischemia: An apoptotic perspective
91. The heme oxygenase system and its functions in the brain
92. The permeability transition pore complex: A target for apoptosis regulation by caspases and bcl-2-related proteins
93. Alterations of Bcl-2 family proteins precede cytoskeletal proteolysis in the penumbra, but not in infarct centers following focal cerebral ischemia in mice
94. Immunocytochemical demonstration of reduced glutathione in neurons of rat forebrain
95. Iron, free radicals, and oxidative injury
96. Differential abundance of superoxide dismutase in interneurons versus projection neurons and matrix versus striosome neurons in monkey striatum
97. Bcl-2 prevents nitric oxide-mediated apoptosis and poly(ADP-ribose) polymerase cleavage
98. 2
99. Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo
100. Hydroxyl radicals and nitric oxide in neurotoxicity and neuroprotection
101. High extracellular potassium modulates nitric oxide synthase expression in human astrocytes
102. Purification and immunohistochemical tissue localization of human xanthine oxidase
103. The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene
104. Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide
105. Iron, metalloenzymes and cytotoxic reactions
106. Upregulation of GABA(A) - Receptor alpha 1- and alpha 2-subunit mRNAs following ischemic cortical lesions in rats
107. Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex
108. Differential expression of superoxide dismutase isoforms in neuronal and glial compartments in the course of excitotoxically mediated neurodegeneration: Relation to oxidative and nitrergic stress
109. Cyclooxygenase-2: Molecular biology, pharmacology, and neurobiology
110. Modulation of glutamate receptor functions by glutathione
111. Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons
112. Localization of extracellular superoxide dismutase in adult mouse brain
113. Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: Different functions in neuronal defense mechanisms?
114. Ebselen: Prospective therapy for cerebral ischaemia
115. Four-dimensional neuronal signaling by nitric oxide: A computational analysis
116. Distribution of mitochondrial manganese superoxide dismutase among rat glial cells in culture
117. Nitric oxide synthase neurons in rat brain express more NMDA receptor mRNA than non-NOS neurons
118. A receptor binding following focal cortical photothrombotic lesions in rat brain
119. Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain
120. MPO and APOE epsilon 4 polymorphisms interact to increase risk for AD in Finnish males
121. Differential effects of suicide transport lesions of the striatonigral or striatopallidal pathways on subsets of striatal neurons
122. Prolonged induction of neuronal NOS expression and activity following cortical spreading depression (SD): Implication for SD- and NO-mediated neuroprotection
123. Oxidants and mitochondrial decay in aging
124. Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis
125. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat
126. Nitric oxide fully protects against UVA-induced apoptosis in tight correlation with Bcl-2 up-regulation
127. The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury
128. Cu/Zn-and Mn-superoxide dismutases are specifically up-regulated in neurons after focal brain injury
129. Immunohistochemical localization of glutathione peroxidase in infarcted human brain
130. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons
131. Neurodegenerative disorders: The role of peroxynitrite
132. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway
133. Colocalization of Bcl-2 and 4-hydroxynonenal modified proteins in microglial cells and neurons of rat brain following transient focal ischemia
134. Neurons in rat cerebral cortex that synthesize nitric oxide: NADPH diaphorase histochemistry, NOS immunocytochemistry, and colocalization with GABA
135. Developmental pattern of NADPH-diaphorase activity and nitric oxide-stimulated cGMP immunoreactivity in the frontal rat cortex and its role in functional recovery from aspiration lesions
136. Heme from Alzheimer's brain inhibits muscarinic receptor binding via thiyl radical generation
137. Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons
138. Brain ischemia and reperfusion: Molecular mechanisms of neuronal injury
139. Delayed and remote effects of focal cortical infarctions: Secondary damage and reactive plasticity
140. Functional differentiation of multiple perilesional zones following focal cerebral ischemia
141. Glutamate agonist-induced hippocampal lesion and nitric oxide synthase/NADPH-diaphorase: A light and electron microscopical study in the rat
142. Models of the diffusional spread of nitric oxide: Implications for neural nitric oxide signalling and its pharmacological properties
143. Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes
144. Cyclooxygenases in central nervous system: Implications for treatment of neurological disorders
145. Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
146. Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat
147. Plasticity and neurotransmitter receptor changes in Alzheimer's disease and experimental cortical infarcts