Expression of NMDA receptor-1 (NR1) and huntingtin in striatal neurons which colocalize somatostatin, neuropeptide Y, and NADPH diaphorase: A double-label histochemical and immunohistochemical study

Experimental Neurology

Volumn 145, Issue 2 I, 1997, Pages 412-424

  Kumar, Ujendra ^a   Asotra, Kamlesh ^a   Patel, S C ^b   Patel, Y C ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXCITOTOXIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE Y; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SOMATOSTATIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL DEATH; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; EMBRYO; GENE EXPRESSION; HISTOCHEMISTRY; HUNTINGTON CHOREA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; STRIATE CORTEX;

EID: 0030793341     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6473     Document Type: Article

References (49)

1. Martin, J. B., and J. F. Gusella. 1986. Huntington's Disease: Pathogenesis and management. N. Engl. J. Med. 315: 1267-1276.
2. Wexler, N. S., E. A. Rose, D. E. Housman. 1991. Molecular approaches to hereditary diseases of the nervous system: Huntington's Disease as a paradigm. Annu. Rev. Neurosci. 14: 503-529.
3. Patel, S. C., K. Asotra, and Y. C. Patel. 1995. Huntington's Disease. Pages 1-20 in J. Patel and L. Pullan, Eds., Emerging Strategies in Neurotherapeutics. Humana Press, Clifton, NJ.
4. Huntington's Disease Collaborative Research Group. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's Disease chromosomes. Cell 72: 971-983.
5. Li, S. H., G. Schilling, W. S. Young, S. J. Li, R. I. Margolis, O. C. Stine, M. V. Wagster, M. H. Abbot, M. L. Franz, N. G. Ramen, S. E. Folstein, J. C. Hedreen, and C. A. Ross. 1993. Huntington's Disease gene (IT15) is widely expressed in human and rat tissues. Neuron 11: 985-993.
6. Strong, T. V., D. A. Tagle, J. Valdes, L. W. Elmer, K. Boehm, M. Swaroop, K. W. Katz, F. S. Collins, and R. L. Albin. 1993. Widespread expression of the human and rat Huntington's Disease gene in brain and nonneuronal tissues. Nature Genet. 5: 259-265.
7. Hoogeveen, A. T., R. Willemsen, N. Meyer, E. de Rooij, R. A. C. Roos, G. B. B. van Ommen, and H. Galjaard. 1993. Characterization and localization of the Huntington's Disease gene product. Hum. Mol. Genet. 2: 2069-2073.
8. Landwehrmeyer, G. B., S. M. McNeil, L. S. Dure, P. Ge, H. Aizawa, Q. Huang, C. M. Ambrose, M. P. Duyao, E. D. Bird, E. Bonilla, M. de Young, A. J. Avila-Gonzales, N. S. Wexler, M. DiFiglia, J. F. Gusella, E. MacDonald, J. B. Penney, A. B. Young, and J. P. Vonsattel. 1995. Huntington's Disease gene: Regional and cellular expression in brain of normal and affected individuals. Ann. Neurol. 37: 218-230.
9. Sharp, A. H., S. J. Loev, G. Schilling, S-H. Li, X-J. Li, J. Bao, M. V. Wagster, J. A. Kotzuk, J. P. Steiner, A. Lo, J. Hedren, S. Sisodia, S. H. Snyder, T. M. Dawson, D. K. Ryugo, and C. A. Ross. 1995. Widespread expression of Huntington's Disease gene (IT15) protein product. Neuron 14: 1065-1074.
10. DiFiglia, M., E. Saap, K. Chase, C. Schwarz, A. Meloni, C. Young, E. Martin, J-P. Vonsattel, R. Carraway, S. A. Reeves, F. M. Boyce, and N. Aronin. 1995. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14: 1075-1081.
11. Reiner A., R. L. Albin, and K. D. Anderson. 1988. Differential loss of striatal projection neurons in Huntington's Disease. Proc. Natl. Acad. Sci. USA 85: 5733-5737.
12. S. R. Vincent, and O. Johansson. 1983. Striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivities and NADPH-diaphorase activity: A light and electron microscopic study. J. Comp. Neurol. 217: 264-270.
13. Aronin, N., P. E. Coper, and L. J. Lorenz. 1983. Somatostatin is increased in the basal ganglia in Huntington's Disease. Ann. Neurol. 13: 519-526.
14. Nemeroff, C. B., W. W. Youngblood, A. J. Prange, Jr., et al. 1983. Regional brain concentrations of neuropeptides in Huntington's chorea and schizophrenia. Science 221: 972-975.
15. Beal, M. F., E. D. Bird, P. J. Langlais, and J. B. Martin. 1984. Somatostatin is increased in the nucleus accumbens in Huntington's disease. Neurology 34: 663-666.
16. Dawbarn, D., M. E. De Quidt, and P. C. Emson. 1985. Survival of basal ganglia neuropeptide Y-1 somatostatin neurones in Huntington's disease. Brain Res. 340: 251-260.
17. Ferrante, R. J., N. W. Kowall, M. F. Beal, E. P. Richardson, Jr., E. D. Bird, and J. B. Martin. 1985. Selective sparing of a class of striatal neurons in Huntington's disease. Science 230: 561-563.
18. Beal, M. F., N. W. Kowall, D. W. Ellison, M. F. Mozurek, K. J. Swartz, and J. B. Martin. 1986. Replication of the neurochemical characteristics of Huntington's Disease by quinolinic acid. Nature 321: 168-171.
19. Qin, Y., J-J. Soghomonian, and M-F. Chesselet. 1992. Effects of quinolinic acid on messenger RNAs encoding somatostatin and glutamic acid decarboxylases in the structure of adult rats. Exp. Neurol. 115: 200-211.
20. Harrington, K. M., and N. M. Kowall. 1991. Parvalbumin immunoreactive neurons resist degeneration in Huntington's Disease striatum. J. Neuropathol. Exp. Neurol. 50: 309.
21. Bredt, D. S., and S. H. Snyder. 1990. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. USA 87: 682-685.
22. Bredt, D. S., P. M. Hwang, and S. H. Snyder. 1990. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347: 768-770.
23. Bredt, D. S., P. M. Hwang, C. E. Glatt, C. Lowenstein, R. R. Reed, and S. H. Snyder. 1991. Cloned and expressed nitric oxide synthase structurally resembles P-450 reductase. Nature 351: 714-718.
24. Beal, M. F., R. J. Ferrante, K. J. Swartz, and N. W. Kowall. 1991. Chronic quinolinic acid lesions in rats closely resemble Huntington's Disease. J. Neurosci. 11: 1649-1659.
25. Patel, S. C., D. N. Papachristou, and Y. C. Patel. 1991. Quinolinic acid stimulates somatostatin gene expression in cultured rat cortical neurons. J. Neurochem. 56: 1286-1291.
26. Koh, J-Y., S. Peters, and D. W. Choi. 1986. Neurons containing NADPH-Diaphorase are selectively resistant to quinolinate toxicity. Science 234: 73-76.
27. Beal, M. F., N. W. Kowall, K. J. Swartz, R. J. Ferrante, and J. B. Martin. 1989. Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions. Synapse 3(1): 38-47.
28. Koh, J-Y., and D. W. Choi. 1988. Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists. Brain Res. 446: 374-378.
29. Patel, Y. C., J. L. Liu, A. Warszynska, G. Kent, D. N. Papachristou, and S. C. Patel. 1995. Differential stimulation of somatostatin but not neuropeptide Y gene expression by quinolinic acid in cultured cortical neurons. J. Neurochem. 65: 998-1006.
30. Young, A. B., J. T. Greenamyre, Z. Hollingsworth, et al. 1988. NMDA receptor losses in putamen from patients with Huntington's disease. Science 241: 981-983.
31. Greenamyre, J. T., and A. Young. 1989. Synaptic localization of striatal NMDA, quisqualate and kainate receptors. Neurosci. Lett. 101: 133-137.
32. Augood, S. J., E. K. McGowan, and P. C. Emson. 1994. Expression of N-methyl-D-aspartate receptor subunit NR1 messenger RNA by identified striatal somatostatin cells. Neuroscience 59: 7-12.
33. Landwehrmeyer, G. B., D. G. Standaert, C. M. Testa, J. B. Penny Jr., and A. B. Young. 1995. NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum. J. Neurosci. 15: 5297-5307.
34. Chen, Q., C. L. Veenman, and A. Reiner. 1996. Cellular expression of ionotropic glutamate receptor subunits on specific striatal neuron types and its implications for striatal vulnerability in glutamate receptor mediated excitotoxicity. Neuroscience 73: 715-731.
35. Dawson, V. L., T. M. Dawson, E. D. London, D. S. Bredt, and S. H. Snyder. 1991. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88: 6368-6371.
36. Dawson, V. L., T. M. Dawson, D. A. Bartley, G. R. Uhl, and S. H. Snyder. 1993. Mechanisms of nitric oxide-mediated neurotoxiity in primary brain cultures. J. Neurosci. 13: 2651-2661.
37. Patel, Y. C., and W. O'Neil. 1988. Peptides derived from cleavage of prosomatostatin at carboxy and amino terminal segments: characterization of tissue and secreted forms in the rat. J. Biol. Chem. 263: 745-751.
38. Nakanishi, S. 1992. Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603.
39. Hope, B. T., and S. R. Vincent. 1989. Histochemical characterization of neuronal NADPH-diaphorase. J. Histochem. Cytochem. 37: 653-661.
40. Ferreiro, D. M., L. J. Arcavi, S. M. Sagar, T. K. McIntosh, and R. P. Simon. 1988. Selective sparing of NADPH-diaphorase neurons in neonatal hypoxia-ischaemi. Ann. Neurol. 24: 670-676.
41. Gonzales, C., R. C. S. Lin, M. F. Chesselet. 1992. Relative sparing of GABAergic interneurons in the striatum of garbits with ischaemic induced lesions. Neurosci. Lett. 135: 53-58.
42. Ipp, E., J. Rivier, R. E. Dobbs, and R. H. Unger. 1979. Somatostatin analogs inhibit somatostatin release. Endocrinology 104: 1270-1273.
43. Peterfreund, R., and W. Vale. 1984. Somatostatin analogs inhibit somatostatin secretion from cultured hypothalamus cells. Neuroendocrinology 39: 397-402.
44. Koch, B. D., and A. Schonbrunn. 1988. Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. J. Biol. Chem. 263: 226-234.
45. Patel, Y. C., M. T. Greenwood, R. Panetta, L. Demchyshyn, N. Niznik, and C. B. Srikant. 1995. The somatostatin receptor family: A mini review. Life Sci. 57: 1249-1265.
46. Duyao, M. P., A. B. Auerbach, A. Ryan, F. Persichetti, G. T. Barnes, S. M. McNeil, P. Ge, J-P. Vonsattel, J. F. Gusella, A. L. Joyner, and M. E. MacDonald. 1995. Inactivation of the mouse Huntington's Disease gene homolog Hdh. Science 269: 407-410.
47. Nasir, J., S. B. Floresco, J. R. O'Kusky, V. M. Diewert, J. M. Richman, J. Zeisler, A. Borowski, J. D. Marth, A. G. Phillips, and M. R. Hayden. 1995. Targeted disruption of the Huntington's Disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81: 811-823.
48. Li, X-J., S-H. Li, A. H. Sharp, F. C. Nucifora, Jr., G. Schilling, A. Lanahan, P. Worley, S. H. Snyder, and C. A. Ross. 1995. A huntingtin-associated protein enriched in brain with implications for pathology. Nature 378: 398-402.
49. Goldberg, P., D. W. Nicholson, D. Rasper, A. Kalchman, H. B. Koide, R. K. Graham, K. E. P. Brown, N. A. Thornberry, J. P. Vaillancourt, and M. R. Hayden. 1996. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease is modulated by the polyglutamine tract. Nature Genom. 13: 442-449.