Enhanced cellular glutathione peroxidase immunoreactivity in activated astrocytes and in microglia during excitotoxin induced neurodegeneration

GLIA

Volumn 24, Issue 2, 1998, Pages 252-256

  Lindenau, Jörg ^a   Noack, Heiko ^a   Asayama, Kotharo ^b   Wolf, Gerald ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Glutathione peroxidase; Microglia; Neuron; Quinolinic acid; Rat

Indexed keywords

GLUTATHIONE PEROXIDASE; NEUROTOXIN; QUINOLINIC ACID;

ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; CENTRAL NERVOUS SYSTEM; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MALE; MICROGLIA; NERVE DEGENERATION; PATHOLOGY; PHYSIOLOGY; RAT; UPREGULATION; WISTAR RAT;

ANIMALS; ASTROCYTES; CENTRAL NERVOUS SYSTEM; GLUTATHIONE PEROXIDASE; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MALE; MICROGLIA; NERVE DEGENERATION; NEUROTOXINS; QUINOLINIC ACID; RATS; RATS, WISTAR; UP-REGULATION;

EID: 0032189894     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199810)24:2<252::AID-GLIA10>3.0.CO;2-Z     Document Type: Article

References (24)

1. Asayama, K., Yokota, S., Dobashi, K,. Hayashibe, H., Kawaoi, A., and Nakazawa, S. (1994) Purification and immunoelectron microscopic localization of cellular gluthathione peroxidase in rat hepatocytes: Quantitative analysis by postembedding method. Histochemistry, 102:213-219.
2. Asayama, K., Yokota, S., Dobashi, K., Kawada, Y., Nakane, T., Kawaoi, A., and Nakazawa, S. (1996) Immunolocalization of cellular glutathione peroxidase in adult rat lungs and quantitative analysis after postembedding immunogold labeling. Histochem. Cell. Biol., 105: 383-389.
3. Blinzinger, K. and Kreutzberg, G.W. (1968) Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z. Zellforsch., 85:145-157.
4. Boje, K.M. and Arora, P.K. (1992) Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res., 587:250-256.
5. Cafe, C., Torry, C., Bertorelli, L., Tartara, F., Tancioni, F., Paolo, G., Baena, R.R., and Marzatico, F. (1995) Oxidative events in neuronal and glial cell enriched fractions of rat cerebral cortex. Free Radical Bio. Med., 19:853-857.
6. Chan, P.H. (1996) Role of oxidants in ischemic brain damage. Stroke, 27:1124-1129.
7. Choi, D.W. (1995) Calcium: still center-stage in hypoxic-ischemic cell death. Trends Neurosci., 18:58-60.
8. Colton, C.A., Snell, J., Chernyshev, O., and Gilbert, D.L., (1994) Induction of Superoxide anion and nitric oxide production in cultured microglia. Ann. NY Acad. Sci., 17:54-63.
9. Coyle, J.T. and Puttfarken, P. (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science, 262:689-695.
10. Damier, P., Hirsch, E.C., Zhang, P., Agid, Y., and Javoy-Agid-F. (1993) Glutathione peroxidase, glia cells and Parkinson's disease. Neuroscience, 52:1-6.
11. Desagher, S., Golwinski, J., and Permont, J. (1996) Astrocytes protect neurons from hydrogen peroxide toxicity. J. Neurosci., 16:2553-2562.
12. Flohé, L. (1982) Glutathione peroxidase brought into focus. Free Radical. Bio. Med., 5:223-254.
13. Graeber, M.B. and Kreuztberg, G.W. (1988) Delayed astrocyte reaction following facial nerve axotomy. J. Neurocytol., 17:209-220.
14. Gehrmann, J. and Kreutzberg, (1995) Microglia in experimental neuropathology. In: Neuroglia. Kettenmann and Ranson, eds. Oxford University Press, New York, pp. 883-904.
15. Huang, J. and Philbert, M.A. (1995) Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells. Brain Res., 680: 16-22.
16. Michiels, C., Raes, M., Toussaint, O., and Remacle, J. (1994) Importance of Se-glutathione peroxidase, catalase and Cu/Zn-SOD for cell survival against oxidative stress. Free Radical Biol. Med., 17:235-248.
17. Noack, H., Lindenau, J., Rothe, F., Asayama, K., and Wolf, G. (1998) Differential expression of Superoxide dismutase in neuronal and glial compartments in the course of excitotoxically mediated neurodegeneration: Relation to oxidative and nitrergic stress. Glia, 23:285-297.
18. Paxinos, G. and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
19. Schmidt, W., Wolf, G., Calka, J., and Schmidt, H.H.H.W. (1995) Evidence for bidirectional changes in nitric oxide synthase activity in the rat striatum after excitotoxically (Quinolinic acid) induced degeneration. Neurosience, 67:345-365.
20. Schulz, J.B., Henshaw, B.R., Siwek, D., Jenkins, B.G., Ferrante R.J., Cipolloni P.B., Kowall N.W., Rosen B.R., and Beal M.F. (1994) Involvement of free radicals in excitotoxicity in vivo. J. Neurochem., 64:2239-2247.
21. Streit, W.J. (1996) Role of microglia in brain injury. Neurotoxicology, 17:671-678.
22. Suemizu, H., Yoshimura, S., Tada, N., Watwanabe, K., and Moriuchi, T. (1992) Production and characterization of two monoclonal antibodies to human glutathione peroxidase. Hybridoma, 11:795-801.
23. Takizawa, S., Matsushiama, K., Shinohara, Y., Ogawa, S., Komatsu, N., Utsunomiya, H., and Watanabe, K., (1994) Immunohistochemical localization of glutathione peroxidase in infarcted human brain. J. Neurol. Sci., 122:66-73.
24. Trépanier, G., Furling, D., Puymirat, J., and Mirault, M.E. (1996) Immunohistochemical localization of seleno-glutathione peroxidase in the adult mouse brain. Neuroscience, 75:231-243.