Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter

Journal of Urology

Volumn 161, Issue 6, 1999, Pages 1968-1972

  Ho, Kossen M T ^b   Ny, Lars ^b   McMurray, Gordon ^b   Andersson, Karl Erik ^b   Brading, Alison F ^a   Noble, Jeremy G ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NONE

Author keywords

Heme oxygenase; Nitric oxide synthase; Urethra

Indexed keywords

CARBON MONOXIDE; HEME OXYGENASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ARTICLE; BLADDER SPHINCTER; ENZYME LOCALIZATION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MICTURITION; NERVE FIBER; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032826433     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)68865-9     Document Type: Article

References (26)

1. Rud, T., Andersson, K-E., Asmussen, M., Hunting, A. and Ulmsten, U.: Factors maintaining the intraurethral pressure in women. Invest. Urol., 17: 343, 1980.
2. Andersson, K-E. and Persson, K.: Nitric oxide synthase and nitric oxide-mediated effects in lower urinary tract smooth muscles. World J. Urol., 12: 274, 1994.
3. Ho, K. M. T., McMurray, G., Brading, A. F., Noble, J. G., Ny, L. and Andersson, K-E.: Nitric oxide synthase in the heterogeneous population of intramural striated muscle fibres of the human membranous urethral sphincter. J. Urol., 159: 1091, 1998.
4. Maines, M. D.: The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol., 37: 517, 1997.
5. Maines, M. D.: Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J., 2: 2557, 1988.
6. Iselin, C. E., Ny, L., Larsson, B., Schaad, N. C., Alm, P., Graber, P., Morel, D. R. and Andersson, K-E.: The nitric oxide synthase/nitric oxide and heme oxygenase/carbon monoxide pathways in the human ureter. Eur. Urol., 33: 214, 1998.
7. Hedlund, P., Ekstrom, P., Larsson, B., Alm, P. and Andersson, K-E.: Heme oxygenase and NO-synthase in the human prostate-relation to adrenergic, cholinergic and peptide-containing nerves. J. Auton. Nerv. Syst., 63: 115, 1997.
8. Liu, J. X., Burnett, A. and Mostwin, J. L.: Carbon monoxide relaxes rat urethral smooth muscle. J. Urol., 153: 460A 1995.
9. Werkstrom, V., Ny, L., Persson, K. and Andersson, K-E.: Carbon monoxide-induced relaxation and distribution of haem oxygenase isoenzymes in the pig urethra and lower oesophagogastric junction. Br. J. Pharmacol., 120: 312, 1997.
10. Waldeck, K., Ny, L., Persson, K. and Andersson, K-E.: Mediators and mechanisms of relaxation in rabbit urethral smooth muscle. Br. J. Pharmacol., 123: 617, 1998.
11. Burnett, A. L., Johns, D. G., Kriegsfeld, L. J., Klein, S. L., Calvin, D. C., Demas, G. E., Schramm, L. P., Tonegawa, S., Nelson, R. J., Snyder, S. H. and Poss, K. D.: Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Nat. Med., 4: 84, 1998.
12. Rattan, S. and Chakder, S.: Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation. Am. J. Physiol., 265: G799, 1993.
13. Ny, L., Alm P., Ekstrom, P., Larsson, B., Grundemar, L. and Andersson, K-E.: Localization and activity of haem oxygenase and functional effects of carbon monoxide in the feline lower oesophageal sphincter. Br. J. Pharmacol., 118: 392, 1996.
14. Ny, L., Alm, P., Larsson, B. and Andersson, K-E.: Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts. J. Auton. Nerv. Syst., 65: 49, 1997.
15. Herbison, A. E., Simonian, S. X., Norris, P. J. and Emson, P. C.: Relationship of neuronal nitric oxide synthase immunoreactivity to GnRH neurons in the ovariectomized and intact female rat. J. Neuroendocrinol., 8: 73, 1996.
16. Utz, J. and Ullrich, V.: Carbon monoxide relaxes ileal smooth muscle through activation of guanylate cyclase. Biochem. Pharmacol., 41: 1195, 1991.
17. Kim, Y. C., Davies, M. G., Marson, L., Hagen, P. O. and Carson, C. C.: Lack of effect of carbon monoxide inhibitor on relaxation induced by electrical field stimulation in corpus cavernosum. Urol. Res., 22: 291, 1994.
18. Iselin, C. E., Alm, P., Schaad, N. C., Larsson, B., Graber, P. and Andersson, K-E.: Localization of nitric oxide synthase and haemoxygenase, and functional effects of nitric oxide and carbon monoxide in the pig and human intravesical ureter. Neurourol. Urodynam., 16: 209, 1997.
19. Grundemar, L. and Ny, L.: Pitfalls using metalloporphyrins in carbon monoxide research. Trends Pharmacol. Sci., 18: 193, 1997.
20. McMillan, K., Bredt, D. S., Hirsch, D. J., Snyder, S. H., Clark, J. E. and Masters, B. S.: Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide. Proc. Natl. Acad. Sci. USA, 89: 1141, 1992.
21. White, K. A. and Marletta, M. A.: Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry, 31: 6627, 1992.
22. Dixon, J. S., Jen, P. Y. and Gosling, J. A.: A double-label immunohistochemical study of intramural ganglia from the human male urinary bladder neck. J. Anat., 190: 125, 1997.
23. Vincent, S. R., Das, S. and Maines, M. D.: Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons. Neuroscience, 63: 223, 1994.
24. Hassall, C. J. and Hoyle, C. H.: Heme oxygenase-2 and nitric oxide synthase in guinea-pig intracardiac neurones. Neuroreport, 8: 1043, 1997.
25. Vollerthun, R., Hohler, B. and Kummer, W.: Guinea-pig sympathetic postganglionic neurones contain haem oxygenase-2. Neuroreport, 7: 173, 1995.
26. Vollerthun, R., Hohler, B. and Kummer, W.: Heme oxygenase-2 in primary afferent neurons of the guinea-pig. Histochem. Cell Biol., 105: 453, 1996.