Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain

Neuroscience Letters

Volumn 273, Issue 2, 1999, Pages 77-80

  Que, Meishu ^a   Schiene, Klaus ^a   Witte, Otto W ^a   Zilles, Karl ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

( ) Amino 3 hydroxy 5 methylisoxazole 4 propionic acid and kainate receptors; Disturbed receptor balance; Focal ischemia; N Methyl D aspartate; Rat brain

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; DIZOCILPINE; GLUTAMATE RECEPTOR; KAINIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUISQUALIC ACID;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HEMISPHERE; MALE; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SPREADING CORTICAL DEPRESSION; THROMBOSIS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; AUTORADIOGRAPHY; BRAIN ISCHEMIA; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; INTRACRANIAL THROMBOSIS; KAINIC ACID; LIGHT; MALE; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS; UP-REGULATION;

EID: 0032869412     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00598-4     Document Type: Article

References (19)

1. Buchkremer-Ratzmann I., August M., Hagemann G., Witte O.W. Electrophysiological transcortical diaschisis after cortical photothrombosis in rat brain. Stroke. 27:1996;1105-1109.
2. Buchkremer-Ratzmann I., Witte O.W. Extended brain disinhibition following small photothrombotic lesions in rat frontal cortex. NeuroReport. 8:1997;519-522.
3. Buchkremer-Ratzmann I., August M., Hagemann G., Witte O.W. Epileptiform discharges to extracellular stimuli in rat neocortical slices after photothrombotic infarction. J. Neurol. Sci. 156:1998;133-137.
4. Dietrich W.D., Feng Z.C., Leistra H., Watson B.D., Rosenthal M. Photothrombotic infarction triggers multiple episodes of cortical spreading depression in distant brain regions. J. Cereb. Blood Flow Metab. 14:1994;20-28.
5. Gass P., Spranger M., Herdegen T., Bravo R., Kock P., Hacke W., Kiessling M. Induction of FOS and JUN proteins after focal ischemia in the rat: differential effect of the N-methyl-D-aspartate receptor antagonist MK-801. Acta. Neuropathol. (Berl.). 84:1992;545-553.
6. Hermann D.M., Mies G., Hossmann K.A. Expression of c-fos, junB, c-jun, MKP-1 and hsp72 following traumatic neocortical lesions in rats - relation to spreading depression. Neuroscience. 88:1999;599-608.
7. Jacobs K.M., Gutnick M.J., Prince D.A. Hyperexcitability in a model of cortical maldevelopment. Cereb. Cortex. 6:1996;514-523.
8. Kawahara N., Croll S.D., Wiegand S.J., Klatzo I. Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance. Neurosci. Res. 29:1997;37-47.
9. Luhmann H.J., Raabe K., Que M., Zilles K. Characterization of neuronal migration disorders in neocortical structures: extracellular in vitro recordings. Eur. J. Neurosci. 10:1998;308-3094.
10. Matsushima K., Schmidt-Kastner R., Hogan M.J., Hakim A.M. Cortical spreading depression activates trophic factor expression in neurons and astrocytes and protects against subsequent focal brain ischemia. Brain Res. 807:1998;47-60.
11. Neumann-Haefelin T., Bosse F., Redecker C., Muller H.W., Witte O.W. Upregulation of GABAA-receptor alpha1- and alpha2-subunit mRNAs following ischemic cortical lesions in rats. Brain Res. 816:1999;234-237.
12. Neumann-Haefelin T., Witte O.W. Peri-infarct and remote excitability changes following transient MCA-occlucion. J. Cereb. Blood Flow Metab. 1999;. in press.
13. A receptor binding following focal cortical photothrombotic lesions in the rat brain. Brain Res. 813:1998;374-380.
14. Que M., Witte O.W., Zilles K. Regulation der glutamatergen und GABAergen Rezeptoren bei kortikalen Läsionen. Ann. Anat. 180:1998;234-235.
15. B receptor binding following cortical photothrombosis: a quantitative receptorautoradiographic study. Neuroscience. 1999;. in press.
16. A receptor binding after a photothrombotically induced neocortical lesion in rats. Eur. J. Pharmacol. 1999;. submitted.
17. Schroeter M., Schiene K., Kraemer M., Hagemann G., Weigel H., Eysel U.T., Witte O.W., Stoll G. Astroglial responses in photochemically induced focal ischemia of the rat cortex. Exp. Brain Res. 106:1995;1-6.
18. B receptors. Eur. J. Neurosci. 10:1998;3095-3106.
19. Zilles K., Que M., Köhling R., Speckmann E.J. Ionoatropic glutamate and γ-aminobutyric acid receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography. Neuroscience. 1999;. in press.