Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons

Neuroscience Research

Volumn 30, Issue 1, 1998, Pages 7-12

  Onitsuka, Meiko ^a   Mihara, Satoshi ^a   Yamamoto, Satoshi ^a   Shigemori, Minoru ^a   Higashi, Hideho ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hemoglobin; Hippocampal CA1 neuron; Intracellular recording; Ischemia; N(G) nitro L arginine Carboxy 2 phenyl 4,4,5,5 tetramethylimidazoline 1 oxyl 3 oxide (carboxy PTIO); Nitric oxide; Superoxide dismutase

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; COBALT; HEMOGLOBIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SCAVENGER; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; HIPPOCAMPUS; NERVE CELL MEMBRANE POTENTIAL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; ANOXIA; BENZOATES; CELL MEMBRANE; COBALT; GLUCOSE; HEMOGLOBINS; HIPPOCAMPUS; IMIDAZOLES; ISCHEMIC ATTACK, TRANSIENT; MALE; MEMBRANE POTENTIALS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; PYRAMIDAL CELLS; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; SUPEROXIDE DISMUTASE;

EID: 0031910419     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(97)00111-9     Document Type: Article

References (31)

1. Akaike T., Yoshida M., Miyamoto Y., Sato K., Kohno M., Sasamoto K., Miyazaki K., Ueda S., Maeda H. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived releasing factor/·NO through a radical reaction. Biochemistry. 32:1993;827-832.
2. Bogle R.G., Moncada S., Pearson J.D., Mann G. Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter. Br. J. Pharmacol. 105:1992;768-770.
3. Buisson A., Plotkine M., Boulu R.G. The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischemia. Br. J. Pharmacol. 106:1992;766-767.
4. Choi D.W. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 18:1995;58-60.
5. Choi D.W., Rothman S.M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13:1990;171-182.
6. Dawson T.M., Snyder S.H. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14:1994;5147-5159.
7. Dawson V.L., Dawson T.M., Bartley D.A., Uhl G.R., Snyder S.H. Mechanisms of nitric oxide mediated neurotoxicity in primary brain cultures. J. Neurosci. 13:1993;2651-2661.
8. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical culture. Proc. Natl. Acad. Sci. USA. 88:1991;6368-6371.
9. Fujimura N., Tanaka E., Yamamoto S., Shigemori M., Higashi H. Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. J. Neurophysiol. 77:1997;378-385.
10. Gross S.S., Wolin M.S. Nitric oxide: pathophysiological mechanisms. Annu. Rev. Physiol. 57:1995;737-769.
11. Hara H., Huang P.L., Panahian N., Fishman M.C., Moskowitz M.A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow Metab. 16:1996;605-611.
12. Higashi H., Sugita S., Matsunari S., Nishi S. Calcium-dependent potentials with different sensitivities to calcium agonists and antagonists in guinea-pig hippocampal neurons. Neuroscience. 34:1990;35-47.
13. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., Moskowitz M.A. Effects of cerebral ischemia in mice deficient neuronal nitric oxide synthase. Science. 265:1994;1883-1885.
14. Izumi Y., Benz A.M., Clifford D.B., Zorumski C.F. Nitric oxide inhibitors attenuate N-methyl-D-aspartate excitotoxicity in rat hippocampal slices. Neurosci. Lett. 135:1992;227-230.
15. Krnjević K., Leblond J. Changes in membrane currents of hippocampal neurons evoked by brief anoxia. J. Neurophysiol. 62:1989;15-30.
16. Kudo Y., Ito K., Miyazaki H., Izumi Y., Ogura A., Kato H. Cytosolic calcium elevation in hippocampal granule cell induced by perforant path stimulation and L-glutamate application. Brain Res. 407:1987;168-172.
17. Lei S.Z., Pan Z.-H., Aggarwal S.K., Chen H.-S.V., Hartman J., Sucher N.J., Lipton S.A. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron. 8:1992;1087-1099.
18. Lipton S.A., Choi Y.-B., Pan Z.-H., Lei S.Z., Chen H.-S.V., Sucher N.J., Loscalzo J., Singel D.J., Stamler J.S. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso- compounds. Nature. 364:1993;626-632.
19. Meldrum B., Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11:1990;379-387.
20. 2+ release. Trends Pharmacol. Sci. 16:1995;356-359.
21. Moncada C., Lekieffre D., Arvin B., Meldrum B. Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions. Neuroreport. 3:1992;530-532.
22. Nagafuji T., Matsui T., Koide T., Asano T. Blockade of nitric oxide formation by N-omega-L-arginine mitigates ischemic brain edema and subsequent cerebral infarction in rats. Neurosci. Lett. 147:1992;159-162.
23. Onitsuka M., Mihara S., Higashi H., Shigemori M. Role of nitric oxide (NO) and temperature in the experimental ischemia-induced membrane dysfunction of hippocampal neurons in vitro. J. Neurotrauma. 12:1995;395.
24. Onitsuka M., Mihara S., Tanaka E., Higashi H. The role of glutamate and nitric oxide (NO) in membrane dysfunction during experimental ischemia in rat hippocampal slices. Jpn. J. Physiol. 46(Suppl):1996;S115.
25. Onitsuka, M., Mihara, S., Inokuchi, H., Shigemori, M., Higashi, H., 1997. Mild hypothermia protects rat hippocampal CA1 neurons from irreversible membrane dysfunction induced by experimental ischemia. Neurosci. Res. 30, 1-6.
26. 2 synthetase inhibitor could protect rat hippocampal neurons from secondary neuronal damage induced by cerebral ischemia in severe head injury. Adv. Neurotrauma Res. 5:1993;44-46.
27. Tanaka, E., Yamamoto, S., Kudo, Y., Mihara, S., Higashi, H., 1997. Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons. J. Neurophysiol. 78, 891-902.
28. Verma A., Hirsch D.J., Glatt C.E., Ronnett G.V., Snyder S.H. Carbon monoxide: a putative neural messenger. Science. 259:1993;381-384.
29. Yamamoto S., Tanaka E., Higashi H. Mediation by intracellular calcium-dependent signals of hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. J. Neurophysiol. 77:1997;386-392.
30. Yamamoto, S., Tanaka, E., Shoji, Y., Kudo, Y., Inokuchi, H., Higashi, H., 1997b. Factors that reverse the persistent depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro. J. Neurophysiol. 78, 903-911.
31. Yoshida M., Akaike T., Wada Y., Sato K., Ikeda K., Ueda S., Maeda H. Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Biochem. Biophys. Res. Commun. 202:1994;923-930.