Enforced polarisation and locomotion of fibroblasts lacking microtubules

Current Biology

Volumn 10, Issue 12, 2000, Pages 739-742

  Kaverina, Irina ^a   Krylyshkina, Olga ^a   Gimona, Mario ^a   Beningo, Karen ^b   Wang, Yu Li ^b   Small, J Victor ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034659215     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00544-3     Document Type: Article

References (19)

1. Vasiliev J.M., Gelfand I.M. Effects of colcemid on morphogenetic processes and locomotion of fibroblasts. Goldman R., Pollard T., Rosenbaum J. Cell Motility. 1976;279-304 Cold Spring Harbor Laboratory, New York.
2. Waterman-Storer C.M., Worthylake R.A., Liu B.P., Burridge K., Salmon E.D. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat Cell Biol. 1:1999;45-50.
3. Kaverina I., Rottner K., Small J.V. Targeting, capture and stabilisation of microtubules at early focal adhesions. J Cell Biol. 142:1998;181-190.
4. Kaverina I., Krylyshkina O., Small J.V. Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J Cell Biol. 146:1999;1033-1043.
5. Izzard C.S., Lochner L.R. Formation of cell-to-substrate contacts during fibroblast motility: an interference reflection study. J Cell Sci. 42:1980;81-116.
6. Pelham R.J., Wang Y-L. High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate. Mol Biol Cell. 10:1999;935-945.
7. Ruoslahti E., Piersbacher M.D. Arg-Gly-Asp: a versatile cell recognition signal. Cell. 44:1986;517-518.
8. Stickel S.K., Wang Y-L. Synthetic peptide GRGDS induces dissociation of alpha actinin and vinculin from the sites of focal contact. J Cell Biol. 107:1988;1231-1239.
9. Rottner K., Hall A., Small J.V. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol. 9:1999;640-648.
10. Sander E.E., ten Klooster J.P., van Delft S., van der Kammen R.A., Collard J.G. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviour. J Cell Biol. 147:1999;1009-1021.
11. Van Leeuwen F.N., van Delft S., Kain H.E., van der Kammen R.A., Collard J.G. Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading. Nat Cell Biol. 1:1999;242-248.
12. Chen W-T. Induction of spreading during fibroblast movement. J Cell Biol. 81:1979;684-691.
13. Dunn G.A. Mechanisms of fibroblast locomotion. Curtis A.S.G., Pitts J.D. Cell Adhesion and Motility. 1980;409-423 Cambridge University Press, Cambridge.
14. Verkhovsky A.B., Svitkina T.M., Borisy G.G. Self polarization and directional motility of cytoplasm. Curr Biol. 9:1999;11-20.
15. Anderson K.I., Cross R.A. Contact dynamics during keratocyte motility. Curr Biol. 10:2000;253-260.
16. Oliver T., Dembo M., Jacobson K. Separation of propulsive and adhesive traction stresses in locomoting keratocytes. J Cell Biol. 145:1999;589-604.
17. Euteneuer U., Schliwa M. Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules. Nature. 310:1984;58-61.
18. Chrzanowska-Wodnicka M., Burridge K. Rho-stimulated contractility drives the formation of stress fibres and focal adhesions. J Cell Biol. 133:1996;1403-1415.
19. Smilenov L.B., Mikhailov A., Pelham R.J., Marcantonio E.E., Gundersen G.G. Focal adhesion motility revealed in stationary fibroblasts. Science. 286:1999;1172-1174.