Role of rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change

Science

Volumn 280, Issue 5365, 1998, Pages 898-902

  Kheradmand, Farrah ^a   Werner, Erica ^a   Tremble, Patrice ^a   Symons, Marc ^a   Werb, Zena ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COLLAGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL SHAPE; CONTROLLED STUDY; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; SYNOVIOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CELL SIZE; COLLAGENASES; CYTOCHALASIN D; ENZYME ACTIVATION; FIBROBLASTS; FREE RADICALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HYDROGEN PEROXIDE; INTERLEUKIN-1; MATRIX METALLOPROTEINASE 1; NF-KAPPA B; RABBITS; RAC GTP-BINDING PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTORS, FIBRONECTIN; TRANSCRIPTION, GENETIC;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0032496326     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5365.898     Document Type: Article

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48. We thank C. Damsky for the gift of anti-α5 (BIIG2) and critical reading of the manuscript and D. Williams-Herman for assistance in preparing the hCL-1/ Luc construct. Supported by NIH grants DE10306 and AR20684 (Z.W.), a fellowship from the American Lung Association, a Mentored Clinician Scientist Award (HL03732) (F.K.), a Pew International Foundation Fellowship (E.W.), and an Institutional National Research Service Award (ES07106).