Differential agonist inhibition identifies multiple epibatidine binding sites in mouse brain

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 1, 1998, Pages 377-386

  Marks, Michael J ^a   Smith, Kimberly W ^a   Collins, Allan C ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUNGAROTOXIN; CYTISINE; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BRAIN MAPPING; CHOLINERGIC TRANSMISSION; CONCENTRATION RESPONSE; DRUG BINDING; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

EID: 0031958663     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. 3H]Methylcarbamyl choline, a new radioligand for studying brain nicotinic receptors. Biochem Pharmacol 35:4199-4202.
2. Albuquerque EX, Alkondon M, Pereira EFR, Castro NG, Schrattcnholz, A, Barbosa CTF, Bonfante-Cabarras R, Aracava Y, Eisenberg HM and Maelicke A (1997) Properties of neuronal nicotinic acetylcholine receptors: Pharmacological characterization and modulation of synaptic function. J Pharmacol Exp Ther 280:1117-1136.
3. Alkondon M and Albuquerque EX (1995) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. III. Agonist actions of the novel alkaloid epibatidine and analysis of type II current. J Pharmacol Exp Ther 274:771-782.
4. 3H-Epibatidine binding: Characterization in rat and human brain. Soc Neurosci Abs 22:1271.
5. Badio B and Daly JW (1994) Epibatidine: A potent analgetic and nicotinic agonist. Mol Pharmacol 45:563-569.
6. Bonhaus DW, Bilgy KR, Broka CA, Fontana DJ, Leung E,Lewis R, Shieh A and Wong EHF (1995) Characterization of the electrophysiological, biochemical and behavioral effects of epibatidine. J Pharmacol Exp Ther 272:1199-1203.
7. 3]N-methyl-carbamyl choline, a new radioligand specific for nicotinic acetylcholine receptors in brain. Eur J Pharmacol 139:323-333.
8. Boulter J, Evans K, Goldman D, Martin G, Treco D, Heinemann S and Patrick J (1986) Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit. Nature 319:368-374.
9. Boulter J, O'Shea-Greenfield A, Duvoisin RM, Connolly JG, Wada E, Jenson A, Gardner PD, Ballivet M, Deneris ES, McKinnon D, Heinemann S and Patrick J (1990) α3 α5 and β4: Three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J Biol Chem 265:4472-4482.
10. Clarke PBS (1992) The fall and rise of neuronal α-bungarotoxin binding proteins. Trends Pharmacol Sci 13:407-413.
11. 125I-α-bungarotoxin-labeled nicotinic receptors in the interpeduncular nucleus of rats. II. Effects of habenular deafferentation. J Comp Neurol 251:407-413.
12. Clarke PBS and Pert A (1985) Autoradiographic evidence for nicotine receptors on nigrostriatal and meso limbic neurons. Brain Res 348:355-358.
13. 125I]-α-bungarotoxin. J Neurosci 5:1307-1315.
14. Couturier S, Bertrand D, Matter J, Hernandez M, Bertrand S, Millar N, Valera S, Barkas T and Ballivet M (1990) A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homoligomeric channel blocked by α-bungarotoxin. Neuron 5:847-856.
15. Damaj MI, Creasy KR, Grove AD, Rosecrans JA and Martin BR (1994) Pharmacological effects of epibatidine optical enantiomers. Brain Res 664:34-40.
16. Deneris GS, Boulter J, Swanson LW, Patrick J and Heinemann S (1989) β3: A new member of nicotinic acetylcholine receptor gene family is expressed in brain. J Biol Chem 264:6268-6272.
17. Deneris GS, Connolly J, Boulter J, Wada G, Wada K, Swanson LW, Patrick J and Heinemann S. (1988) Primary structure and expression of β2: A novel subunit of neuronal nicotinic acetylcholine receptors. Neuron 1:45-54.
18. Dinely-Miller K and Patrick J (1992) Gene transcripts for the nicotinic receptor subunit. Beta 4, are distributed in multiple areas of the rat central nervous system. Mol Brain Res 16:339-344.
19. Duvoisin RM, Deneris GS, Patrick J and Heinemann S (1989) The functional diversity of the neuronal nicotinic acelylcholine receptors is increased by a novel subunit: β4. Neuron 3:487-496.
20. Elgoyhen AB, Johnson DS, Boulter J, Vetter DE and Heinemann S (1994) α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79:705-715.
21. Fisher M, Hangtu D, Shen TY and Guyenet PG (1994) Epibatidine, an alkaloid from the poison dart frog, Epipedobates tricolor, is a powerful ganglionic depolarizing agent. J Pharmacol Exp Ther 270:702-707.
22. Flores CM, DeCamp RD, Kilo S, Rogers SW and Hargreaves KM (1996) Neuronal nicotinic receptor expression in sensory neurons of the rat trigeminal ganglion: Demonstration of α3β4, a novel subtype in the mammalian nervous system. J Neurosci 16:7894-7901.
23. Flores CM, Rogers SW, Pabreza LA, Wolfe BB and Kellar KJ (1992) A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol 41:31-37.
24. Gerzanich V, Peng X, Wang F, Wells G, Anand R, Fletcher S and Lindstrom J (1995) Comparative pharmacology of epibatidine: A potent agonist for neuronal acetylcholine receptors. Mol Pharmacol 48:774-782.
25. Goldman D, Deneris G, Luyten W, Kochhar A, Patrick J and Heinemann S (1987) Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system. Cell 48:965-973.
26. 3H]-epibatidine binding to nicotinic cholinergic receptors in rat and human brain. Mol Pharmacol 48:280-287.
27. Luetje CW, Wada K, Rogers S, Abramson SN, Tsuji K, Heinemann S and Patrick J (1990) Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. J Neurochem 55:632-640.
28. Lindstrom JM (1995) Nicotinic acetylcholine receptors, in Handbook of Receptors and Channels: Ligand-and Voltage-Gated Ion Channels (North, RA ed) pp 153-175, CRC Press, Boca Raton, FL.
29. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
30. 3H]acetylcholine binding sites. J Pharmacol Exp Ther 253:51-57.
31. 3H]nicotine binding to a nicotinic cholinergic receptor in PC12 cells. Endocrinology 130:825-830.
32. Marks MJ and Collins AC (1982) Characterization of nicotine binding in mouse brain and comparison with the binding of α-bungarotoxin and quinuclindinyl benzilate. Mol Pharmacol 22:554-564.
33. Marks MJ, Pauly JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Heinemann SF and Collins AC (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12:2765-2784.
34. + efflux from mouse thalamic synaptosomes. J Pharmacol Exp Ther 277:1383-1396.
35. Marks MJ, Stitzel JA, Romm E, Wehner JM and Collins AC (1986) Nicotinic binding sites in rat and mouse brain: Comparison of acetylcholine, nicotine and α-bungarotoxin. Mol Pharmacol 30:427-436.
36. 3H](-)nicotine label the same recognition site in rat brain. Mol Pharmacol 31:169-174.
37. Oswald RE and Freeman JA (1981) Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors. Neuroscience 6:1-14.
38. 3H]Cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 39:9-12.
39. 3H]-cytisine binding in rat and mouse brain. Soc Neurosci Abstr 22:1264.
40. Pauly JR, Stitzel JA, Marks MJ and Collins AC (1989) An autoradiographic analysis of cholinergic receptors in mouse brain. Brain Res Bull 22:455-459.
41. 3H]Epibatidine labels nicotinic receptors in rat brain: An autoradiographic study. J Pharmacol Exp Ther 275:1030-1034.
42. Picciotto MR, Zoll M, Léna C, Bessis A, Lallemand Y, LeNovére N, Vincent P, Merlo Pich E, Brûlet, P and Changeux JP (1995) Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in brain. Nature 374:65-67.
43. Qian C, Lu T, Shan TY, Libertine-Garahan L, Eckman J, Bittu T and Ip S (1993) Epibatidine is a nicotinic analgesic. Eur J Pharmacol 250:R13-R14.
44. Romano C and Goldstein A (1980) Stereospecific nicotine receptors on rat brain membranes. Science 210:647-649.
45. Schoepfer R, Conroy WG, Whiting P, Gora M and Lindstrom J. (1990) Brain α-bungarotoxin binding protein cDNAs and m Abs reveal subtypes of this branch of the ligand-gated ion channel super family. Neuron 5:35-48.
46. 125I-neuronal bungarotoxin. J Neurosci 11:287-297.
47. 3H]acetylcholine on catecholamine and serotonin axons in brain. J Neurochem 42:1495-1498.
48. 3H]acetylcholine in rat brain. Mol Pharmacol 22:56-62.
49. Seguela P, Wadiche J, Dinely-Miller K, Dani JA and Patrick J (1993) Molecular cloning, functional properties, and distribution of rat brain α7: a nicotinic channel highly permeable to calcium. J Neurosci 13:596-604.
50. Spande TF, Garraffo HM, Edwards MW, Yeh HJC, Pannell W and Daly JW (1992) A novel (chloropyridyl) azabicyloheptane with potent analgesic activity from an Ecuadoran poison frog. J Am Chem Soc 114:3475-3478.
51. Sullivan JP, Decker MW, Brioni JD, Donnelly-Roberts D, Anderson DJ, Bannon AW, Kang C-H., Adams P, Plattoni-Kaplan M, Buckley MJ, Gopalakrishnan M, Williams M and Arneric SP (1994) (±)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors. J Pharmacol Exp Ther 271:624-631.
52. Swanson L, Simmons D, Whiting P and Lindstrom J (1987) Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system. J Neurosci 7:3334-3342.
53. Wada E, McKinnon D, Heinemann S, Patrick J and Swanson LW (1990) The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (α5) in the rat central nervous system. Brain Res 526:45-53.
54. Wada E, Wada K, Boulter J, Deneris E, Heinemann S, Patrick J and Swanson LW (1989) Distribution of alpha-2, alpha-3, alpha-4 and beta-2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat. J Comp Neurol 284:314-335.
55. Wada K, Ballivet M, Boulter J, Connolly JG, Wada E, Deneris ES, Swanson LW, Heinemann S and Patrick J (1988) Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor. Science 240:330-334
56. Whiting PJ and Lindstrom J (1988) Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies. J Neurosci 8:3395-3404.
57. Whiting PJ, Liu R, Morley BJ and Lindstrom JM (1987) Structurally different neuronal nicotinic acetylcholine receptor subtypes purified and characterized using monoclonal antibodies. J Neurosci 7:4005-4016.