Phenotypic characterization of an α4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse

Journal of Neuroscience

Volumn 20, Issue 17, 2000, Pages 6431-6441

  Ross, Shelley A ^a   Wong, John Y F ^a   Clifford, Jeremiah J ^c   Kinsella, Anthony ^d   Massalas, Jim S ^a   Horne, Malcolm K ^a   Scheffer, Ingrid E ^a,e   Kola, Ismail ^b   Waddington, John L ^c   Berkovic, Samuel F ^e   Drago, John ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^d DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Anxiety; Behavioral topography; Homologous recombination; Knock out; Nicotinic receptor; 4

Indexed keywords

CYTISINE; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CAUDATE NUCLEUS; CONTROLLED STUDY; FERTILITY; HOMOZYGOSITY; ISOTOPE LABELING; KNOCKOUT MOUSE; MAZE TEST; MOTOR ACTIVITY; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; THALAMUS; TISSUE DISTRIBUTION;

EID: 0034280436     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-17-06431.2000     Document Type: Article

References (58)

1. Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test
2. The pharmacology of (-)-nicotine and novel cholinergic channel modulators
3. A genetic comparison of behavioral actions of ethanol and nicotine in the mirrored chamber
4. Brain nicotinic receptors: Structure and regulation, role in learning and reinforcement
5. Nicotine and smoking: A perspective from animal studies
6. The effects of nicotine on locomotor activity in non-tolerant and tolerant rats
7. Heterogeneity of behavioural profile between three new putative selective D3 dopamine receptor antagonists using an ethologically based approach
8. Topographical evaluation of the phenotype of spontaneous behaviour in mice with targeted gene deletion of the D1(A) dopamine receptor: Paradoxical elevation of grooming syntax
9. Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclase
10. Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor
11. The actions of nicotine and cocaine in a mouse model of anxiety
12. Distribution of nicotinic receptors in the CNS
13. A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX
14. Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice
15. Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for CNS therapeutics
16. Beta 3: A new member of nicotinic acetylcholine receptor gene family is expressed in brain
17. Altered striatal function in a mutant mouse lacking D1A dopamine receptors
18. The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: Beta 4
19. Alpha 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells
20. Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
21. The mouse brain in stereotaxic coordinates
22. Nicotinic cholinergic receptors in human brain: Effects of aging and Alzheimer
23. Paradoxical tranquilizing and emotion-reducing effects of nicotine
24. Effects of smoking/nicotine on anxiety, heart rate, and lateralization of EEG during a stressful movie
25. Immunocytochemical localization of a neuronal nicotinic receptor: The beta 2-subunit
26. Effect of buspirone on withdrawal symptoms associated with smoking cessation
27. Tobacco withdrawal in self-quitters
28. Signs and symptoms of tobacco withdrawal
29. Symptoms of tobacco withdrawal. A replication and extension
30. Nicotine withdrawal versus other drug withdrawal syndromes: Similarities and dissimilarities
31. Characterization of tobacco withdrawal symptoms: Transdermal nicotine reduces hunger and weight gain
32. 3H]gamma-aminobutyric acid in the substantia nigra and in the globus pallidus of the rat
33. Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells
34. Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain
35. Evidence for 'preterminal' nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus
36. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
37. Transdermal nicotine replacement and smoking cessation
38. Nicotinic receptor activation facilitates GABAergic neurotransmission in the avian lateral spiriform nucleus
39. The occurrence of tolerance to a central depressant effect of nicotine
40. Pharmacological aspects of withdrawal from certain benzodiazepines
41. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents
42. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
43. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
44. Nicotinic receptors in the brain. Links between molecular biology and behavior
45. Nicotine as a psychoactive drug: Anxiety and pain reduction
46. Efficacy of buspirone in smoking cessation: A placebo-controlled trial
47. The effect of bupropion on nicotine craving and withdrawal
48. A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy
49. An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy
50. Nicotine-induced antinociception in rats and mice: Correlation with nicotine brain levels
51. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
52. Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus laevis oocytes
53. Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
54. The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (alpha 5) in the rat central nervous system
55. Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouse
56. Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor
57. Identification of four classes of brain nicotinic receptors using beta2 mutant mice