(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB- 1508Y): A novel anti-Parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors

Journal of Medicinal Chemistry

Volumn 39, Issue 17, 1996, Pages 3235-3237

  Cosford, N D P ^a   Bleicher, L ^a   Herbaut, A ^a   McCallum, J S ^a   Vernier J , M ^a   Dawson, H ^a   Whitten, J P ^a   Adams, P ^a   Chavez Noriega, L ^a   Correa, L D ^a   Crona, J H ^a   Mahaffy, L S ^a   Menzaghi, F ^a   Rao, T S ^a   Reid, R ^a   Sacaan, A I ^a   Santori, E ^a   Stauderman, K A ^a   Whelan, K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ETHYNYL 5 (1 METHYL 2 PYRROLIDINYL)PYRIDINE; ANTIPARKINSON AGENT; DIHYDRO BETA ERYTHROIDINE; DOPAMINE; MECAMYLAMINE; MUSCARINIC RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; QUINUCLIDINYL BENZILATE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG ANTAGONISM; DRUG DISCRIMINATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; PARKINSON DISEASE; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPARKINSON AGENTS; CELL LINE; FEMALE; HUMANS; KINETICS; MOLECULAR STRUCTURE; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PYRIDINES; PYRROLIDINES; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; STEREOISOMERISM; XENOPUS;

EID: 0029784854     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960328w     Document Type: Article

References (0)