Heteromeric complexes of α5 and/or α7 subunits. Effects of calcium and potential role in nicotine-induced presynaptic facilitation

Annals of the New York Academy of Sciences

Volumn 868, Issue , 1999, Pages 578-590

  Girod, R ^a   Crabtree, G ^a   Ernstrom, G ^a   Ramirez Latorre, J ^b   McGehee, D ^c   Turner, J ^a   Role, L ^a  

^a The New York Presbyterian Hospital   (United States)

^b TEMPLE UNIVERSITY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; IONOTROPIC RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT;

ANXIETY; AROUSAL; ATTENTION; BEHAVIOR; BIOPHYSICS; CALCIUM CELL LEVEL; CELL MEMBRANE POTENTIAL; CONDUCTANCE; CONFERENCE PAPER; DEPOLARIZATION; MEMORY; MUTAGENESIS; NONHUMAN; PERMEABILITY; PHARMACOLOGY; PHYSIOLOGY; PRESYNAPTIC NERVE; TRANSPORT KINETICS;

EID: 0033010406     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb11331.x     Document Type: Conference Paper

References (81)

1. Schroder, H., E. Giacobini, A. Wevers, C. Birtsch & U. Schutz. 1995. Nicotinic receptors in Alzheimer's disease. Brain Imag. Nicotine Tob. Smok. :73-93.
2. Vidal, C. 1996. Nicotinic receptors in the brain. Molecular biology, function, and therapeutics. Mol. Chem. Neuropathol. 28: 3-11.
3. Cachelin, A.B. & R. Jaggi. 1991. Beta subunits determine the time course of desensitization in rat alpha 3 neuronal nicotinic acetylcholine receptors. Pflugers Arch. 419: 579-582.
4. Gross, A., M. Ballivet, D. Rungger & D. Bertrand. 1991. Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes: Role of the alpha subunit in agonist sensitivity and desensitization. Pflugers Arch. 419: 545-551.
5. 2 dopaminergic receptors mediate inhibition of excitatory synaptic transmission in rat neostriatum. Brain Res. 690: 264-268.
6. Fenster, C.P., M.F. Rains, B. Noerager, M.W. Quick. & R.A. Lester. 1997. Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine. J. Neurosci. 17: 5747-5759.
7. Vibat, C.R., J.A. Lasalde, M.G. McNamee & E.L. Ochoa. 1995. Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus laevis oocytes. Cell Mol. Neurobiol. 15: 411-425.
8. Dani, J.A. & S. Heinemann. 1996. Molecular and cellular aspects of nicotine abuse. Neuron 16: 905-908.
9. Wonnacott, S. 1997. Presynaptic nicotinic ACh receptors. Trends Neurosci. 20: 92-98.
10. Boulter, J., K. Evans, D. Goldman, G. Martin, D. Treco, S. Heinemann & J. Patrick. 1986. Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor a-subunit. Nature 319: 368-374.
11. Le Novere, N. & P. Changeux. 1995. Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells. J. Mol. Evol. 40: 155-172.
12. Ortells, M.O. & G.C. Lunt. 1995. Evolutionary history of the ligand-gated ion-channel super-family of receptors. TINS 18: 121-127.
13. Patrick, J., P. Sequela, S. Vernino, M. Amador, C. Luetje & J.A. Dani. 1993. Functional diversity of neuronal nicotinic acetylcholine receptors. Prog. Brain Res. 98: 113-120.
14. Sargent, P.B. 1993. The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16: 403-433.
15. Lindstrom, J., R. Anand, X. Peng, V. Gerzanich, F. Wang & Y. Li. 1995. Neuronal nicotinic receptor subtypes. Ann. N.Y. Acad. Sci. 757: 100-116.
16. McGehee, D.S. & L.W. Role. 1995. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu. Rev. Physiol. 57: 521-546.
17. Changeux, J.P., A. Bessis, J.P. Bourgeois, P.J. Corringer, A. Devillers-Thiery, J.L. Eisele, M. Kerszberg, C. Lena, N. Le Novere, M. Picciotto & M. Zoll 1996. Nicotinic receptors and brain plasticity. Cold Spring Harbor Symp. Quant. Biol. 61: 343-362.
18. Colquhoun, L.M. & J.W. Patrick. 1997. Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv. Pharmacol. 39: 191-220.
19. Couturier, S., D. Bertrand, J.M. Matter, M.C. Hernandez, S. Bertrand, N. Millar, S. Valera, T. Barkas & M. Ballivet. 1990. A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX. Neuron 5: 847-856.
20. Schoepfer, R., W.G. Conroy, P. Whiting, M. Gore & J. Lindstrom. 1990. Brain alpha-bungarotoxin binding protein cDNAs and mAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily. Neuron 5: 35-48.
21. Seguela, P., J. Wadiche, K. Dineley-Miller, J. Dani & J.W. Patrick. 1993. Molecular cloning, functional properties, and distribution of rat a7: A nicotinic cation channel highly permeable to calcium. J. Neurosci. 13: 596-604.
22. Elgoyhen, A.B., D.S. Johnson. J. Boulter, D.E. Vetter & S. Heinemann. 1994. Alpha 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79: 705-715.
23. Gerzanich, V., R. Anand & J. Lindstrom. 1994. Homomers of a8 and a7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties. Mol. Pharmacol. 45: 212-220.
24. Papke, R.L., M. Bencherif & P. Lippiello. 1996. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. Neurosci. Lett. 213: 201-204.
25. Alkondon, M., E.F. Pereira, C.T. Barbosa & E.X. Albuquerque. 1997. Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices. J. Pharmacol. Exp. Ther. 283: 1396-1411.
26. Alkondon, M., E.F. Pereira, W.S. Cortes, A, Maelicke & E.X. Albuquerque. 1997. Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. Eur. J. Neurosci. 9: 2734-2742.
27. Alkondon, M. & E.X. Albuquerque. 1991. Initial characterization of the nicotinic acetylcholine receptors in rat hippocampal neurons. J. Recept. Res. 11: 1001-1021.
28. Alkondon, M. & E.X. Albuquerque. 1993. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther. 265: 1455-1473.
29. Sivilotti, L.G., D.K. McNeil, T.M. Lewis. M.A. Nassar, R. Schoepfer & D. Colquhoun. 1997. Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. J. Physiol. (Lond.) 500: 123-138.
30. Conroy, W.G., A.B. Vernallis & D.K. Berg. 1992. The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain. Neuron 9: 679-691.
31. Boulter, J., J. Connolly, E. Deneris, S. Goldman, S. Heinemann & J. Patrick. 1987. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proc. Natl. Acad. Sci. USA 84: 7763-7767.
32. Wada, E., D. McKinnon, S. Heinemann, J. Patriclk & L.W. Swanson. 1990. The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (alpha 5) in the rat central nervous system. Brain Res. 526: 45-53.
33. Ramirez-Latorre, J., C.R. Yu, X. Qu, F. Perin, A. Karlin & L. Role. 1996. Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels. Nature 380: 347-351.
34. Wang, D.X. & L.G. Abood. 1996. Expression and characterization of the rat alpha 4 beta 2 neuronal nicotinic cholinergic receptor in baculovirus-infected insect cells. J. Neurosci, Res. 44: 330-354.
35. Forsayeth, J.R. & E. Kobrin. 1997. Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor. J. Neurosci. 17: 1531-1538.
36. Gerzanich, V., A. Kuryatov, R. Anand & J. Lindstrom. 1997. "Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholinc receptor. Mol. Pharmacol. 51: 320-327.
37. Role, L.W. & D.K. Berg. 1996. Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16: 1077-1085.
38. Chen, D. & J.W. Patrick. 1997. The alpha-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the alpha7 subunit. J. Biol. Chem. 272: 24024-24029.
39. Gerzanich, V., R. Anand & J. Lindstrom. 1994. Homomers of α8 and α7 subunits of nicotinic receptors exhibit similar channel but contrasting binding sites properties. Mol. Pharmacol. 45: 212-220.
40. McGehee, D., M. Heath, S. Gelber, P. Deva & L.W. Role. 1995. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269: 1692-1697.
41. Gray, R., A.S. Rajan, K.A. Radcliffe, M. Yakehiro & J.A. Dani. 1996. Hippocampal synaptic transmission enhanced by low concentrations of nicotine [see comments]. Nature 383: 713-716.
42. Liang, S.D. & S. Vizi. 1997. Positive feedback modulation of acetylcholine release from isolated rat superior cervical ganglion. J. Pharmacol. Exp. Ther. 280: 650-655.
43. Gou, J.Z., T.L. Tredway & V.A. Chiappinelli. 1998. Glutamate and GABA release are enhanced by different subtypes of presynaptic nicotinic receptors in the lateral geniculate nucleus. J. Neurosci. 18: 1963-1969.
44. Yu, C.R. & L.W. Role. 1998. Functional contribution of the alpha5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurones. J. Physiol. (Lond.) 509: 667-681.
45. Yu, C.R. & L.W. Role. 1998. Functional contribution of the alpha7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones. J. Physiol. (Lond.) 509: 651-665.
46. Mulle, C., D. Choquet, H. Korn & J.P. Changeux. 1992. Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation. Neuron 8: 135-143.
47. Vernino, S., M. Amador, C.W. Luetje, J. Patrick & J.A. Dani. 1992. Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8: 127-134.
48. Bertrand, D., J.H. Galzi, A. Devillers-Thiery, S. Bertrand & J.P. Changeux. 1993. Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal α7 nicotinic receptor. Proc. Natl. Acad. Sci. USA 90: 6971-6975.
49. Seguela, P., J. Wadiche, K. Dineley-Miller, J.A. Dani & J.W. Patrick. 1993. Molecular cloning, functional properties, and distribution of rat brain alpha 7: A nicotinic cation channel highly permeable to calcium. Neurosci. 13: 596-604.
50. Vernino, S., M. Rogers, K.A. Radcliff & J.A. Dani. 1994. Quantitative measurement of calcium flux through muscle and neuronal nicotinic acetylcholine receptors. J. Neurosci. 14: 5514-5524.
51. Albuquerque, E.X., E.F. Pereira, N.G. Castro, M. Alkondon, S. Reinhardt, H. Schroder & A. Maelicke. 1995. Nicotinic receptor function in the mammalian central nervous system. Ann. N.Y. Acad. Sci. 757: 48-72.
52. Rogers, M. & J.A. Dani. 1995. Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels. Biophys. J. 68: 501-506.
53. Zwart, R., R.G. Van Kleef, J.M. Milikan, M. Oortgiesen & H.P. Vijverberg. 1995. Potentiation and inhibition of subtypes of neuronal nicotinic acetylcholine receptors by Pb2+. Eur. J. Pharmacol. 291: 399-406.
54. Galzi, J.L., S. Bertrand, P.J. Corringer, J.P. Changeux & D. Bertrand. 1996. Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor. Embo J. 15: 5824-5832.
55. Wilkie, G.I., P. Hutson, J.P. Sullivan & S. Wonnacott. 1996. Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes. Neurochem. Res. 21: 1141-1148.
56. Castro, N.G. & E.X. Albuquerque. 1995. The α-bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability. Biophys. J. 68: 516-524.
57. Zwart, R., M. Oortgiesen & H.P. Vijverberg. 1992. The nitromethylene heterocycle l-(pyridin-3-yl-methyl)-2-nitromethylene-imidazolidine distinguishes mammalian from insect nicotinic receptor subtypes. Eur. J. Pharmacol. 228: 165-169.
58. Neuhaus, R. & A.B. Cachelin. 1990. Changes in the conductance of the neuronal nicotinic acetylcholine receptor channel induced by magnesium. Proc. R. Soc. Lond. B241: 78-84.
59. Sands, S.B., A.C. Costa & J.W. Patrick. 1993. Barium permeability of neuronal nicotinic receptor alpha 7 expressed in Xenopus oocytes. Biophys. J. 65: 2614-2621.
60. Nutter, T.J. & D.J. Adams. 1995. Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia. J. Gen. Physiol. 105: 701-723.
61. Amador, M. & J.A. Dani. 1995. Mechanism for modulation of nicotinic acetylcholine receptors that can influence synaptic transmission. J. Neurosci. 15: 4525-4532.
62. Connolly, J.G., A.J. Gibb & D. Colquhoun. 1995. Heterogeneity of neuronal nicotinic acetylcholine receptors in thin slices of rat medial habenula. J. Physiol. (Lond.) 484: 87-105.
63. Brussaard, A.B., X. Yang, J.P. Doyle, S. Huck & L.W. Role. 1994. Developmental regulation of multiple nicotinic AChR channel subtypes in embryonic chick habenula neurons: Contributions of both the alpha 2 and alpha 4 subunit genes. Pflugers Arch. 429: 27-43.
64. 2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors. J. Neurosci. 17: 9035-9047.
65. Sargent, P.B., S.H. Pike, D.B. Nadel & J.M. Lindstrom. 1989. Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog. J. Neurosci. 9: 565-573.
66. Coggan, J.S., J. Paysan, W.G. Conroy & D.K. Berg. 1997. Direct recording of nicotinic responses in presynaptic nerve terminals. J. Neurosci. 17: 5798-5806.
67. 3H]-dopamine release. Br. J. Pharmacol. 117: 595-606.
68. 3H]dopamine release from rat striatal synaptosomes. J. Neurochem. 67: 163-170.
69. Sacaan, A.I., J.L. Dunlop & G.K. Lloyd. 1995. Pharmacological characterization of neuronal acetylcholine gated ion channel receptor-mediated hippocampal norepinephrine and striatal doparnine release from rat brain slices. Pharmacol. Exp. Ther. 274: 224-230.
70. 3H]dopamine release from rat striatal synaptosomes and slices. J. Neurochem. 70: 1069-1076.
71. Kiss, J.P., H, Sershen, A. Lajtha & E.S. Vizi. 1996. Inhibition of neuronal nitric oxide synthase potentiates the dimethylphenylpiperazinium-evoked carrier-mediated release of noradrenaline from rat hippocampal slices. Neurosci. Lett. 215: 115-118.
72. Sershen, H., A. Balla, A. Lajtha, & E.S. Vizi. 1997. Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus. Neuroscience 77: 121-130.
73. Alkondon, M., E.S. Rocha, A. Maelicke & E.X. Albuquerque. 1996. Diversity of nicotinic acetylcholine receptors in rat brain. V. Alpha Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release. J. Pharmacol. Exp. Ther. 278: 1460-1471.
74. Sargent, P.B. & D.Z. Pang. 1989. Acetylcholine receptor-like molecules are found in both synaptic and extrasynaptic clusters on the surface of neurons in the frog cardiac ganglion. Neurosci. 9: 1062-1072.
75. Alkondon, M., E.F. Pereira & E.X. Albuquerque. 1996. Mapping the location of functional nicotinic and gamma-aminobutyric acids receptors on hippocampal neurons. J. Pharmacol. Exp. Ther. 279: 1491-1506.
76. Lena, C., J.-P. Changeux & C. Mulle. 1993. Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus. J. Neurosci. 13: 2680-2688.
77. Benowitz, N.L. 1990. Pharmacokinetic considerations in understanding nicotine dependence. CIBA Found. Symp. 152: 186-200.
78. Benowitz, N.L., H. Porchet & P.D. Jacob. 1989. Nicotine dependence and tolerance in man: Pharmacokinetic and pharmacodynamic investigations. Prog. Brain Res. 79: 279-287.
79. Pidoplichko, V.I., M. DeBiasi, J.T. Williams & J.A. Dani. 1997. Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390: 401-404.
80. 2+ modulation of α4β2 and α4α5β2 combinations of neuronal nicotinic receptors. Soc. Neurosci. Abstr.
81. 2+ regulation of neuronal nicotinic receptors including the α7 and α5 subunits. Soc. Neurosci. Abstr.