Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors

Journal of Medicinal Chemistry

Volumn 39, Issue 4, 1996, Pages 817-825

  Abreo, Melwyn A ^a   Lin, Nan Horng ^a   Garvey, David S ^a   Gunn, David E ^a   Hettinger, Ann Marie ^a   Wasicak, James T ^a   Pavlik, Patricia A ^a   Martin, Yvonne C ^a   Donnelly Roberts, Diana L ^a   Anderson, David J ^a   Sullivan, James P ^a   Williams, Michael ^a   Arneric, Stephen P ^a   Holladay, Mark W ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 2 PYRROLIDINONE; 3 (2 AZETIDINYLMETHOXY)PYRIDINE; 3 [(1 METHYL 2 PYRROLIDINYL)METHOXY]PYRIDINE FUMARATE; A 84543; AZETIDINE; AZETIDINE 2 CARBOXYLIC ACID; BRAIN RECEPTOR; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; COGNITIVE DEFECT; HUMAN; HUMAN CELL; NONHUMAN; PARASYMPATHETIC INNERVATION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; AZOCINES; BINDING, COMPETITIVE; BRAIN; CELL LINE; CELL MEMBRANE; ETHERS; GANGLIA; HUMANS; MOLECULAR STRUCTURE; NEURONS; NICOTINIC AGONISTS; PYRIDINES; QUINOLIZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 13344282051     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9506884     Document Type: Article

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