Transcriptional control of the neuronal nicotinic acetylcholine receptor gene cluster by the β43' enhancer, Sp1, SCIP and ETS transcription factors

European Journal of Pharmacology

Volumn 393, Issue 1-3, 2000, Pages 69-74

  Deneris, Evan S ^a   Francis, Nicole ^a   McDonough, Jenny ^a   Fyodorov, Dmitry ^a   Miller, Tim ^a   Yang, Xiangdong ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Enhancer; Neuron; Nicotinic receptor; Promoter; Transcription

Indexed keywords

NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; TRANSCRIPTION FACTOR;

ANIMAL CELL; CELL STRAIN; CONFERENCE PAPER; CONTROLLED STUDY; GENE CLUSTER; GENE EXPRESSION REGULATION; IN VITRO STUDY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NEURONS; OCTAMER TRANSCRIPTION FACTOR-6; PC12 CELLS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RATS; RECEPTORS, NICOTINIC; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0034732161     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00883-3     Document Type: Conference Paper

References (19)

1. Battaglioli E., Gotti C., Terzano S., Flora A., Fornasari F. Expression and transcriptional regulation of the human α3 neuronal nicotinic receptor subunit in T lymphocytes cell lines. J. Neurochem. 71:1998;1261-1270.
2. Bermingham J.R.J., Scherer S.S., O'Connell S., Arroyo E., Kalla K.A., Powell F.L., Rosenfeld M.G. Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. Genes Dev. 10:1996;1751-1762.
3. Boulter J., Duvoisin R.M., Connolly J.G., Wada E., Jensen A., Gardner P.D., Ballivet M., Deneris E.S., McKinnon D., Heinemann S., Patrick J. α3, α5, and β4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J. Biol. Chem. 265:1990;4472-4482.
4. Boyd R.T. Transcriptional regulation and cell specificity determinants of the rat nicotinic acetylcholine receptor α3 gene. Neurosci. Lett. 208:1996;73-76.
5. Conroy W.G., Berg D.K. Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit compositions. J. Biol. Chem. 9:1995;4424-4431.
6. Couturier S., Erkman L., Valera S., Rungger D., Bertrand S., Boulter J., Ballivet M., Bertrand D. α5, α3, and non-α3: three clustered avian genes encoding neuronal nicotinic acetylcholine receptor-related subunits. J. Biol. Chem. 265:1990;17560-17567.
7. Francis N., Deneris E. The neuronal nAchR β43′ enhancer is neuron-selective and preferentially active in retinal versus sympathetic neurons. Soc. Neurosci. Abstr. 24:1998;1565.
8. Fyodorov D., Deneris E. The POU domain of SCIP/Tst-1/Oct-6 is sufficient for activation of an acetylcholine receptor promoter. Mol. Cell. Biol. 16:1996;5004-5014.
9. Fyodorov D., Nelson T., Deneris E. Pet-1, a novel ETS domain factor that can activate neuronal nAchR gene transcription. J. Neurobiol. 34:1998;151-163.
10. McDonough J., Deneris E. β43′: an enhancer displaying neural-restricted activity is located in the 3′-untranslated exon of the rat nicotinic acetylcholine receptor β4 gene. J. Neurosci. 17:1997;2273-2283.
11. Raimondi E., Rubboli F., Moralli D., Chini B., Fornasari D., Tarroni P., De-Carli L., Clementi F. Chromosomal localization and physical linkage of the genes encoding human alpha3, alpha5, and beta4 neuronal nicotinic receptor subunits. Genomics. 12:1992;849-850.
12. Vailati S., Hanke W., Bejan A., Barabino B., Longhi R., Balestra B., Moretti M., Clementi F., Gotti C. Functional α6-containing nicotinic receptors are present in chick retina. Mol. Pharmacol. 56:1999;11-19.
13. Vernallis A.B., Conroy W.G., Berg D.K. Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes. Neuron. 10:1993;451-464.
14. Wasylyk B., Hahn S.L., Giovane A. The Ets family of transcription factors. Eur. J. Biochem. 211:1993;7-18.
15. Weinstein D.E., Burrola P.G., Lemke G. Premature Schwann cell differentiation and hypermyelination in mice expressing a targeted antagonist of the POU transcription factor SCIP. Mol. Cell. Neurosci. 6:1995>;212-229.
16. Yang X., Fyodorov D., Deneris E.S. Transcriptional analysis of acetylcholine receptor alpha 3 gene promoter motifs that bind Sp1 and AP2. J. Biol. Chem. 270:1995;8514-8520.
17. Yang X., McDonough J., Fyodorov D., Morris M., Wang F., Deneris E.S. Characterization of an acetylcholine receptor alpha 3 gene promoter and its activation by the POU domain factor SCIP/Tst-1. J. Biol. Chem. 269:1994;10252-10264.
18. Yang X., Yang F., Fyodorov D., Wang F., McDonough J., Herrup K., Deneris E. Elements between the protein-coding regions of the adjacent β4 and α3 acetylcholine receptor genes directs neuron-specific expression in the central nervous system. J. Neurobiol. 32:1997;311-324.
19. Zoli M., Lena C., Picciotto M.R., Changeux J.-P. Identification of four classes of brain nicotinic receptors using β2 mutant mice. J. Neurosci. 18:1998;4461-4472.