Neuroprotective effects of 2,4-dimethoxybenzylidene anabaseine (DMXB) and tetrahydroaminoacridine (THA) in neocortices of nucleus basalis lesioned rats

Brain Research

Volumn 786, Issue 1-2, 1998, Pages 252-254

  Meyer, Edwin M ^a   King, Michael A ^a   Meyers, Craig ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Choline acetyltransferase; Neocortical atrophy; Nicotinic; Nissl staining; Trans synaptic

Indexed keywords

ANABASINE DERIVATIVE; BENZYLIDENE DERIVATIVE; CHOLINESTERASE INHIBITOR; NICOTINIC AGENT; TACRINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN DEGENERATION; BRAIN INJURY; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NEOCORTEX; NEUROPROTECTION; NISSL SUBSTANCE; NONHUMAN; OLIVARY NUCLEUS; PRIORITY JOURNAL; RAT;

EID: 0032498950     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00300-4     Document Type: Article

References (21)

1. [1] A. Akaike, Y. Tamura, Y. Takeharu, S. Shimohama, J. Kimura, Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity, Brain Res. 644 (1994) 181-187.
2. [2] G.W. Arendash, W.J. Millard, A.J. Dunn, E.M. Meyer, Long term neuropathological and neurochemical effects of nucleus basalis lesions in the rat, Science 238 (1987) 952-956.
3. [3] G.W. Arendash, W.J. Millard, R. Dawson, E.M. Meyer, Differential neurochemical effects of unilateral versus bilateral nucleus basalis lesions in the rat, Neurochem. Res. 14 (1989) 1113-1119.
4. [4] G.E. Barrantes, A.T. Rogers, J. Lindstrom, S. Wonnacott, α-Bungarotoxin binding sites in rat hippocampal and cortical cultures: initial characterisation, colocalization with α 7 subunits and up-regulation by chronic nicotine treatment, Brain Res. 672 (1995) 228-236.
5. [5] K.A. Carson, C. Geula, M.M. Mesulam, Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue, Brain Res. 540 (1991) 204-208.
6. [6] R.P.A. Gaykema, J.C. Compaan, C. Nyakas, E. Horvath, P.G.M. Luiten, Long term effects of cholinergic basal forebrain lesions on neuropeptide Y and somatostatin immunoreactivity in rat neocortex, Brain Res. 489 (1989) 392-396.
7. [7] J.S. Hanker, L.P. Thornburg, P.E. Yates, H.G. Moore, The demonstration of cholinesterase by the formation of osmium blacks at the sites of Hatchett's brown, Histochemie 37 (1973) 233.
8. [8] B.H. Hunter, R.L. Papke, C.M. de Fiebre, E.M. Meyer, Facilitation of hippocampal LTP by an apparent α7 nicotinic agonist, Neurosci. Lett. 168 (1994) 130-134.
9. [9] D.S. Johnson, H.M. Stroessner-Johnson, J. Boulter, D.G. Amaral, S. Heinemann, Distribution of α7 neuronal nicotinic receptor mRNA in the rat CNS, Soc. Neurosci. Abstr. 17 (1991) 249.
10. [10] T. Koike, D.P. Martin, E.M. Johnson, Role of calcium channels in the ability of membrane depolarization to prevent neuronal death induced by trophic factor deprivation: evidence that levels of internal calcium determine nerve growth factor dependence on sympathetic ganglionic cells, Proc. Natl. Acad. Sci. USA 86 (1989) 6421-6425.
11. [11] E.J. Martin, K.S. Panicker, M.A. King, M. Deyrup, B.E. Hunter, E.M. Meyer, Cytoprotective action of 2,4-methoxybenzylidene anabaseine in differentiated PC12 cells and septal cholinergic neurons, Drug Dev. Res. 31 (1994) 127-134.
12. [12] E.M. Meyer, C.M. de Fiebre, B.E. Hunter, C.E. Simpkins, N.E. de Fiebre, Effects of anabaseine related analogs on rat brain nicotinic receptor binding and on avoidance behavior, Drug Dev. Res. 31 (1994) 135-141.
13. [13] W.J. Millard, G.W. Arendash, A.J. Dunn, E.M. Meyer, Effects of nucleus basalis lesions on cerebral cortical concentrations of corticotropin-releasing hormone like immunoreactivity in the rat, Neurosci. Lett. 113 (1990) 233-239.
14. [14] G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, Orlando, FL, 1986.
15. [15] L. Regeur, G. Badsberg, H. Jensen, H. Pakkenberg, S.M. Evans, B. Pakkenberg, No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type, Neurobiol. Aging 15 (1994) 347-352.
16. [16] H. Schroeder, E. Giacobini, R.G. Struble, K. Zilles, A. Maelicke, Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimers disease, Neurobiol. Aging 12 (1991) 259-262.
17. [17] N.N. Sjak-Shie, E.M. Meyer, Effects of chronic nicotine and pilocarpine administration on neocortical neuronal density and GABA uptake in nucleus basalis lesioned rats, Brain Res. 624 (1993) 295-298.
18. [18] W.C. Wallace, V. Bragin, N.K. Robackis, K. Sambamurti, D. VenderPuttren, C.R. Merril, K.L. Davis, A.C. Santucci, V. Haroutunian, Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert, Mol. Brain Res. 10 (1991) 173-178.
19. [19] C.L. Wellman, D.R. Sengelaub, Alterations in dendritic morphology of frontal cortical neurons after basal forebrain lesions in adult and aged rats, Brain Res. 669 (1995) 48-58.
20. [20] S.C. Wright, J. Zhong, H. Zheng, J.W. Larrick, Nicotine inhibition of apoptosis suggests a role in tumor promotion, FASEB J. 7 (1993) 1045-1051.
21. [21] J.A. Zoltewicz, K. Prokai-Tatrai, L.B. Bloom, W.R. Kem, Long range transmission of polar effects in cholinergic 3-arylidene anabaseines. Conformations calculated by molecular modelling, Heterocyclics 35 (1993) 171-179.