Fluid flow rapidly activates G proteins in human endothelial cells: Involvement of G proteins in mechanochemical signal transduction

Circulation Research

Volumn 79, Issue 4, 1996, Pages 834-839

  Gudi, Siva R P ^a   Clark, Craig B ^a   Frangos, John A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

endothelial cells; G protein; shear stress; signal transduction

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; BLOOD FLOW; ENZYME ACTIVATION; HEMODYNAMICS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SHEAR STRESS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

EID: 0029822797     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.79.4.834     Document Type: Article

References (29)

1. Nerem RM. Vascular fluid mechanics, the arterial wall, and atherosclerosis. J Biomech Eng. 1992;114:274-282.
2. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev. 1995;75:519-560.
3. Nollert MU, Eskin SG, McIntire LV. Shear stress increases inositol trisphosphate levels in human endothelial cells. Biochem Biophys Res Commun. 1990;170:281-287.
4. Prasad ARS, Logan SA, Nerem RM, Schwartz CJ, Sprague EA. Flow-related responses of intracellular inositol phosphate levels in cultured aortic endothelial cells. Ore Res. 1993;72:827-836.
5. Bhagyalakshmi A, Berthiaume F, Reich KM, Frangos JA. Fluid shear stress stimulates membrane phospholipid metabolism in cultured human endothelial cells. J Vasc Res. 1992;29:443-449.
6. Kuchan MJ, Jo H, Frangos JA. Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells. Am J Physiol. 1994;267:C753-C758.
7. Kuchan MJ, Frangos JA. Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells. Am J Physiol. 1994;266:C628-C636.
8. Frangos JA, Eskin SG, McIntire LV, Ives CL. Flow effects on prostacyclin production by cultured human endothelial cells. Science. 1985;27:1477-1479.
9. Berthiaume F, Frangos JA. Flow-induced prostacyclin production is mediated by a pertussis toxin-sensitive G protein. FEBS Lett. 1992;308:277-279.
10. Bhagyalakshmi A, Frangos JA. Mechanism of shear-induced prostacyclin production in endothelial cells. Biochem Biophys Res Commun. 1989;158:31-37.
11. Kuchan MJ, Frangos JA. Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am J Physiol. 1993;264:H150-H156.
12. Tseng H, Peterson TE, Berk BC Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Circ Res. 1995;77:869-878.
13. Hsieh HJ, Li NQ, Frangos JA. Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C. J Cell Physiol. 1992;150:552-558.
14. Hsieh HJ, Li NQ, Frangos JA. Pulsatile and steady flow induces c-fos expression in human endothelial cells. J Cell Physiol. 1993;154:143-151.
15. Simon MI, Strathmann MP, Guatam N. Diversity of G proteins in signal transduction. Science, 1991;252:802-808.
16. Frangos JA, McIntire LV, Eskin SG. Shear stress induced stimulation of mammalian cell metabolism. Biotech Bioeng. 1988;32:1053-1060.
17. αi3 in Chinese hamster ovary cells. J Biol Chem. 1993;268:5676-5685.
18. Pfeuffer T. GTP-binding proteins in membranes and the control of adenylate cyclase activity. J Biol Chem. 1977;252:7224-7234.
19. 1-adrenergic receptor. J Biol Chem. 1990;265:18944-18951.
20. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
21. Shen J, Luscinskas FW, Connolly A, Dewey CF Jr, Gimbrone MA Jr. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol. 1992;262:C384-C390.
22. Geiger RV, Berk BC, Alexer RW, Nerem RM. Flow-induced calcium transients in single endothelial cells: spatial and temporal analysis. Am J Physiol. 1992;262:C1411-C1417.
23. Berridge MJ, Irvine RF. Inositol phosphates and cell signalling. Nature. 1989;341:197-205.
24. Kanai AJ, Strauss HC, Truskey GA, Crews AL, Grunfeld S, Malinski T. Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. Circ Res. 1995;77:284-293.
25. Gooch KJ, Frangos JA. Flow- and bradykinin-induced nitric oxide production by endothelial cells is independent of membrane potential. Am J Physiol. 1996;262:C546-C551.
26. Jacobs ER, Cheliakine C, Gebremedhin D, Davies PF, Harder DR. Shear activated channels in cell-attached patches of aortic endothelial cells. FASEB J. 1993;7:71. Abstract.
27. Dewitz TS, Martin RR, Solis RT, Hellums JD, McIntire LV. Microaggregate formation in whole blood exposed to shear stress. Microvasc Res. 1978;16:263-271.
28. Schwartz MA, Ingber DE. Integrating with integrins. Mol Biol Cell. 1994;5:389-393.
29. Berthiaume F, Frangos JA. Fluid flow increases membrane permeability to merocyanine 540 in human endothelial cells. Biochim Biophys Acta. 1994;1191:209-218.